DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and atp1a1b

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_571765.1	Gene:	atp1a1b / 64616	ZFINID:	ZDB-GENE-001212-5	Length:	1025	Species:	Danio rerio

Alignment Length:	1075	Identity:	332/1075 - (30%)
Similarity:	514/1075 - (47%)	Gaps:	183/1075 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLL 67
            |.|..|:|:....:|||..||||..:......:.|||.|........|....:|.......:|..
Zfish    43 DDHKLTLEELNRKYGTDLNRGLTTARAAEILARDGPNALTPPPTTPEWVKFCKQMFGGFSMLLWT 107

  Fly    68 AAIISF----VLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGK 128
            .|::.|    :.|..|:.......:: .:|:..::|.......:||..:...:::.|...|:...
Zfish   108 GALLCFLAYGIQAAMEDEPANDNLYL-GVVLSAVVIITGCFSYYQEAKSSKIMDSFKNLVPQQAL 171

  Fly   129 VVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDA 193
            |||..:.  ..|.|:|:|.||||||..||:||||:||  |.|...::|.|.|||||....:..|.
Zfish   172 VVRDGEK--NHVNAEEVVVGDLVEVKGGDRIPADLRI--IASHGCKVDNSSLTGESEPQTRSPDY 232

  Fly   194 IPDPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGE 258
            ..|...   :.:||.|..||...|.|||:||.||..|.:|:|.|..|..|..:||:..:::.|..
Zfish   233 SNDNPL---ETRNIAFFSTNCVEGTARGIVISTGDRTVMGRIATLASGLEVGRTPISIEIEHFIH 294

  Fly   259 QLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGT 323
            .::.|...:.|:.:.:::      |.|.||::..|:    .:.:.||.:||||.|.:|.||.|..
Zfish   295 IITGVAVFLGVSFFVLSL------ALGYSWLEAVIF----LIGIIVANVPEGLLATVTVCLTLTA 349

  Fly   324 RRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDS----SFLEFEM 384
            :||||||.:|::|.:|||||.||.||||||||||.|:|:|:.|:..:::...|:    |...|:.
Zfish   350 KRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGTSFDR 414

  Fly   385 TGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLA 449
            :.:|:..:..|  .|...:|.   .|.|.:.:.|:..|.|             |:|:|:||:...
Zfish   415 SSATWASLARV--AGLCNRAV---FLAEQTDVPILKRDVA-------------GDASESALLKCI 461

  Fly   450 EKLNSFSVNKSGLDRRSAAIACRGEIE---TKWKKEFTLEF-SRDRKSMSSYCTPLKASRLGTGP 510
            |                   .|.|.::   .|:.|...:.| |.::..:|.:..|    ..||..
Zfish   462 E-------------------LCCGSVKDMREKYTKVAEIPFNSTNKYQLSVHKNP----NGGTES 503

  Fly   511 K--LFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY------------GTGRDTLR- 560
            |  |.:|||||.:|:||:           |..::.|:.||..:.            |.|...|.
Zfish   504 KHLLVMKGAPERILDRCS-----------TILIQGKVQALDDEMKEAFQNAYLELGGLGERVLGF 557

  Fly   561 ---CLALAVADSPMKPDEMDLGDSTKFYQYEV-----NLTFVGVVGMLDPPRKEVFDSIVRCRAA 617
               ||          ||| :..:...|...:|     ||.|||::.|:||||..|.|::.:||:|
Zfish   558 CHFCL----------PDE-EFPEGFPFDTEDVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSA 611

  Fly   618 GIRVIVITGDNKATAEAICRRIGVFAEDEDTTGKSYSGR---EFDDLSPTEQKAAVARSR----- 674
            ||:||::|||:..||:||.:.:|:.:|..:|. :..:.|   ..::::|.:.||.|....
Zfish   612 GIKVIMVTGDHPITAKAIAKGVGIISEGNETV-EDIAARLNIPVNEVNPRDAKACVVHGGDLKDL 675

  Fly   675 ---------------LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SG 723
                           :|:|..||.|..|||..|....|.|:|||||||:||||||:||:||| :|
Zfish   676 SCEQLDDILKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAG 740

  Fly   724 TAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALI 788
            :.|:|.||:|:|.||||:|||:.|||||.|::|:|:.|.|.::|||.|:....|.....:|..|.
Zfish   741 SDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLG 805

  Fly   789 PVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPR--KAD----EGLISGWLFFRYMAIGFYVGAA 847
            .|.:|.::|.||.|||.:|.:...:.|||::.||  |.|    |.|||    ..|..||..  .|
Zfish   806 TVTILCIDLGTDMLPAISLAYEAAESDIMKRQPRNPKTDKLVNERLIS----IAYGQIGMI--QA 864

  Fly   848 TVGAAAWWFVFSDEGPKLS-------YWQLTHHLSCL--GGGDEFKGVDCKI--FSDPHAMTMAL 901
            ..|...::.:.|:.|...|       ||. ..|::.|  ..|.::.....||  |:...|...::
Zfish   865 LAGFFTYFVILSENGFLPSRLLGIRVYWD-DKHINDLEDSYGQQWTYEQRKIVEFTCHTAFFASI 928

  Fly   902 SVLVTIEML---NAMNSL----SENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQV 959
            .|:...:::   ...||:    .:|:.||       ..|....||:..|.    |...:....::
Zfish   929 VVVQWADLIICKTRRNSVFQQGMKNKILI-------FGLFEETALAAFLS----YCPGMDVALRM 982

  Fly   960 TPLSAEEWITVMKFSIPVVLLDETLKFVARKIADG 994
            .||....|.....:|:.:.:.||..|.:.|:...|
Zfish   983 YPLKPNWWFCAFPYSLLIFIYDEMRKLILRRNPGG 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	329/1066 (31%)
atp1a1b	NP_571765.1	ATPase-IIC_X-K	32..1025	CDD:273445	332/1075 (31%)
		Cation_ATPase_N	41..115	CDD:214842	20/71 (28%)
		E1-E2_ATPase	135..366	CDD:278548	86/247 (35%)
		Cation_ATPase	428..523	CDD:289987	32/144 (22%)
		COG4087	608..754	CDD:226572	58/146 (40%)
		Cation_ATPase_C	801..1010	CDD:279079	57/226 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930