Protein Alignment SERCA and atp1a1a.3

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_571763.1
• Gene: atp1a1a.3 / 64614
• ZFINID: ZDB-GENE-001212-3
• Length: 1024
• Species: Danio rerio
• Alignment Length: 1075
• Identity: 322/1075 - (29%)
• Similarity: 509/1075 - (47%)
• Gaps: 184/1075 - (17%)

  Fly     3 DGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLL 67
            |.|..|:|:....:|||..:||::.:.|....:.|||.|........|.....|.......:|.:
Zfish    43 DDHKLTLEELSRKYGTDLNKGLSITRAKEILARDGPNALTPPVTTPEWVKFCRQLFGGFQTLLWI 107

  Fly    68 AAIISF----VLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGK 128
            .|::.|    :.|..||.......:: .||:..::..|.....:||..:...:::.:...|:...
Zfish   108 GALLCFFAYSIQAASEEEPANDNLYL-GLVLAFVVTVNGCFSYYQEAKSSRIMDSFRNLVPQKAL 171

  Fly   129 VVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDA 193
            |||:.:..:  :.|:::|.||||||..||:|||||||  :.|...::|.|.|||||.
Zfish   172 VVREGEKSV--IDAEDVVVGDLVEVKGGDRIPADIRI--VSSQGCKVDNSSLTGESE-------- 224

  Fly   194 IPDPRAVNQ------DKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQK 252
             |..||...      :.:||.|..||...|.|||||:.||..|.:|:|.:..|..|..:||:.::
Zfish   225 -PQTRAPEMSSDNPLETRNIAFFSTNCVDGAARGVVVNTGDRTVMGRIASLASSLEGGQTPIARE 288

  Fly   253 LDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITT 317
            ::.|...::.|...:.:....:::      ..|.:|::|.|:    .:.:.||.:||||||.:|.
Zfish   289 IEHFIHIITGVAVFLGLTFLVLSL------ILGYNWLEGVIF----LIGIIVANVPEGLPATVTV 343

  Fly   318 CLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEF 382
            ||.|..:||||||.:|::|.:|||||.|:.||||||||||.|:|:|:.|:..:.:...|::   .
Zfish   344 CLTLTAKRMAKKNCLVKNLEAVETLGSTTTICSDKTGTLTQNRMTVAHMWFDNHIHIADTT---E 405

  Fly   383 EMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNE-----FKQAFEKVGEATE 442
            ..||::::          |..|    |...|:.:..:||.:....|:     .|:  :..|:|:|
Zfish   406 NQTGASFD----------RSSA----TWSALARVAGLCNRAVFQSNQSHIPVLKR--DTAGDASE 454

  Fly   443 TALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLG 507
            :||:...| |:..||               .|:...:.|...:.|:    |.:.|...:..:...
Zfish   455 SALLKCIE-LSCGSV---------------AEMRENYTKLAEIPFN----STNKYQVSIHKNPNS 499

  Fly   508 TGPK--LFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY----GTGRDTLRCLALAV 566
            :.||  |.:|||||.:||||:...:...:.|:...:|.   |....|    |.|...|......:
Zfish   500 SEPKHLLVMKGAPERILERCSTIFIQGKEQPMDDEMKD---AFQNAYLELGGLGERVLGFCHFCL 561

  Fly   567 ADSPMKPDEMDLG---DSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDN 628
            .|     |:...|   |:.:......||.|||::.|:||||..|.|::.:||:|||:||::|||:
Zfish   562 PD-----DQFPEGFAFDTEEMNFPTENLCFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDH 621

  Fly   629 KATAEAICRRIGVFAEDEDTTGKSYSGR---EFDDLSPTEQKAAVARSR---------------- 674
            ..||:||.:.:|:.:|..:|. ...:.|   ..|:::|.:.||.|....
Zfish   622 PITAKAIAKGVGIISEGNETV-DDIAARLKIHIDEVNPRDAKACVIHGGELKNMTDEQLDDVLQH 685

  Fly   675 ----LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMV 734
                :|:|..||.|..|||..|....|.|:|||||||:||||||:||:||| :|:.|:|.||:|:
Zfish   686 HTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMI 750

  Fly   735 LADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVT 799
            |.||||:|||:.|||||.|::|:|:.|.|.::|.|.|:....:...:|:|..|..|.:|.::|.|
Zfish   751 LLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSKIPEMSPFLMFVLVGIPLPLGTVTILCIDLGT 815

  Fly   800 DGLPATALGFNPPDLDIMEKPPRKA------DEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVF 858
            |.:||.:|.:...:.|||::.||.|      :|.|||    ..|..||.   ...||....:||.
Zfish   816 DMVPAISLAYETAESDIMKRQPRNAATDRLVNERLIS----VSYGQIGM---IQAVGGFFTYFVI 873

  Fly   859 SDEGPKLSY--------WQLTHHLSCL--GGGDEFKGVDCKIFS-DPHAMTMALSVLVTIEMLNA 912
            ..|...|.|        |: ...|:.|  ..|.::.....||.. ..|....|..|:|
Zfish   874 LAENGFLPYDLVGIRVGWE-DRFLNDLEDSYGQQWTYESRKIVEYTCHTAFFASIVIV------- 930

  Fly   913 MNSLSENQSLITMPPWCNLWLIGSMALSF--------TLHFVIL----------YVDVLSTVFQV 959
                          .|.:|.:..:..||.        .|.|.:|          |...:....::
Zfish   931 --------------QWTDLLICKTRRLSIFQQGMKNRVLTFGLLEETALAAFLSYCPGMEVAVRM 981

  Fly   960 TPLSAEEWITVMKFSIPVVLLDETLKFVARKIADG 994
            .||....|.....:|:.:.:.||..|::.|:...|
Zfish   982 YPLKPLWWFCAFPYSLLIFIYDEVRKYILRRNPGG 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	319/1066 (30%)
atp1a1a.3	NP_571763.1	ATPase-IIC_X-K	32..1024	CDD:273445	322/1075 (30%)