DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and atp1a2a

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_571758.1	Gene:	atp1a2a / 64609	ZFINID:	ZDB-GENE-001212-6	Length:	1017	Species:	Danio rerio

Alignment Length:	1062	Identity:	317/1062 - (29%)
Similarity:	504/1062 - (47%)	Gaps:	159/1062 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLL 67
            |.|..|:::....:|.|..||||..:......:.|||.|........|....:|.......:|.:
Zfish    37 DDHKLTLDELSTRYGVDLARGLTHKRAMEILARDGPNALTPPPTTPEWVKFCKQLFGGFSILLWI 101

  Fly    68 AAIISFVLALFEEHEETFTAFVEP--------LVILLILIANAVVGVWQERNAESAIEALKEYEP 124
            .||:.|:....:...|.     ||        :|:..::|.......:||..:...:::.|...|
Zfish   102 GAILCFLAYSIQAATED-----EPVNDNLYLGVVLSAVVIITGCFSYYQEAKSSRIMDSFKNMVP 161

  Fly   125 EMGKVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIK 189
            :...|:| |...:| :.|:|:|.|||||:..||::|||:||  |.|:..::|.|.|||||....:
Zfish   162 QQALVIR-DGEKLQ-INAEEVVQGDLVEIKGGDRVPADLRI--ISSSGCKVDNSSLTGESEPQTR 222

  Fly   190 HTDAIPDPRAVNQ---DKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQ 251
                  .|...::   :.:||.|..||...|.|.|:||.||..|.:|:|.|..|..|..:||:..
Zfish   223 ------SPEFTHENPLETRNISFFSTNCVEGTAHGIVIATGDHTVMGRIATLASGLEVGQTPINM 281

  Fly   252 KLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVIT 316
            :::.|...::.|...:.::.:.::|      ..|.:|::..|:    .:.:.||.:||||.|.:|
Zfish   282 EIEHFIHIITGVAIFLGMSFFILSI------ILGYTWLEAVIF----LIGIIVANVPEGLLATVT 336

  Fly   317 TCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVE----GNDS 377
            .||.|..:|||:||.:|::|.:|||||.||.||||||||||.|:|:|:.|:..:::.    ..|.
Zfish   337 VCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQ 401

  Fly   378 SFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKV----- 437
            |..:|:.:..|:                     ..||.:..:||.:.     ||...|::
Zfish   402 SGCDFDKSSPTW---------------------FSLSRVGGLCNRAV-----FKAGQEEIPIRTR 440

  Fly   438 ---GEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCT 499
               |:|:|:||:...|.|:.......|.:|:.|.|    ...:..|.:.::....|        :
Zfish   441 DTAGDASESALLKCVEILSGNVETLRGNNRKVAEI----PFNSTNKYQLSIHELED--------S 493

  Fly   500 PLKASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY----GTGRDTLR 560
            |       ||..|.:|||||.:|:||:...:...:.|:....   :.|..|.|    |.|...|.
Zfish   494 P-------TGHLLVMKGAPERILDRCSTIMINGVEFPIDDDW---MDAFQGAYMELGGLGERVLG 548

  Fly   561 CLALAVADSPM-KPDEMDLGDSTKFYQYEVN-LTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIV 623
            ...|.::.|.. :..|.|..|    ..:.|| |.|:|::.|:||||..|.|::.:||:|||:||:
Zfish   549 FCHLFLSPSQFPRGFEFDCDD----VNFPVNQLCFLGLISMVDPPRAAVPDAVGKCRSAGIKVIM 609

  Fly   624 ITGDNKATAEAICRRIGVFAEDEDTTGKSYSGR---EFDDLSPTEQKAAVARSR----------- 674
            :|||:..||:||.:.:|:.:|..:|. :..:.|   ....::|.|.||.|....
Zfish   610 VTGDHPITAKAIAKGVGIISEGNETV-EDIAERLNIPLSQVNPREAKACVVHGSDLKDMSSEYLD 673

  Fly   675 ---------LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKS 729
                     :|:|..||.|..|||..|....|.|:|||||||:||||||:||:||| :|:.|:|.
Zfish   674 DILRNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGITGSDVSKQ 738

  Fly   730 AAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLW 794
            ||:|:|.||||:|||:.|||||.|::|:|:.|.|.::|||.|:....|.....:|..|..|.:|.
Zfish   739 AADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIASVPLPLGTVTILC 803

  Fly   795 VNLVTDGLPATALGFNPPDLDIMEKPPR--KAD----EGLISGWLFFRYMAIGFYVGAATVGAAA 853
            ::|.||.:||.:|.:...:.|||::.||  |.|    |.|||       ||.|.......:|...
Zfish   804 IDLGTDMVPAISLAYESAESDIMKRQPRNPKTDKLVNERLIS-------MAYGQIGMIQALGGFF 861

  Fly   854 WWFVFSDE---------GPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEM 909
            .:||...|         |.:|.:...|.:....|.|.::.....||..    .|...|..|:|.:
Zfish   862 TYFVIMAENGFLPQTLLGIRLDWDDRTVNDLEDGYGQQWTYEQRKIIE----FTCHTSFFVSIVV 922

  Fly   910 LNAMNSL--SENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMK 972
            :...:.:  ...::.:......|..||..:.....|...:.|...:....::.||....|.....
Zfish   923 VQWADLIICKTRRNSVFQQGMKNRILIFGLFAETALAAFLSYCPGMDVALRMYPLKIMWWFCAFP 987

  Fly   973 FSIPVVLLDETLKFVARKIADG 994
            :|:.:.:.||..||:.|:...|
Zfish   988 YSLLIFVYDEIRKFILRRNPGG 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	314/1053 (30%)
atp1a2a	NP_571758.1	ATPase-IIC_X-K	34..1017	CDD:273445	317/1062 (30%)
		Cation_ATPase_N	35..109	CDD:214842	19/71 (27%)
		E1-E2_ATPase	129..360	CDD:278548	79/250 (32%)
		Cation_ATPase	422..515	CDD:289987	30/116 (26%)
		COG4087	600..746	CDD:226572	59/146 (40%)
		Cation_ATPase_C	793..1002	CDD:279079	51/219 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920