Protein Alignment SERCA and ATP13A1

DIOPT Version :9

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_065143.2
• Gene: ATP13A1 / 57130
• HGNCID: 24215
• Length: 1204
• Species: Homo sapiens
• Alignment Length: 1174
• Identity: 250/1174 - (21%)
• Similarity: 420/1174 - (35%)
• Gaps: 389/1174 - (33%)

  Fly     4 GHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLA 68
            |::.:..||...|..|.|       |:|.:||:|.|:.         ::|:..|.:|..:   .|
Human   197 GNAFSYYQSNRGFQEDSE-------IRAAEKKFGSNKA---------EMVVPDFSELFKE---RA 242

  Fly    69 AIISFVLALF-------EE--HEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEP 124
            ....||..:|       :|  :...||        |.:|:|.....|.|:....|.|..:.. :|
Human   243 TAPFFVFQVFCVGLWCLDEYWYYSVFT--------LSMLVAFEASLVQQQMRNMSEIRKMGN-KP 298

  Fly   125 EMGKVVRQDKSGIQKVRAKEIVPGDLVEVSVG-----DKIPADIRITHIYSTTLR----IDQSIL 180
            .|.:|.|..|  .:.:.:.||||||:  ||:|     :.:|.|:.:       ||    :|:::|
Human   299 HMIQVYRSRK--WRPIASDEIVPGDI--VSIGRSPQENLVPCDVLL-------LRGRCIVDEAML 352

  Fly   181 TGESVSVIKH--TDAIPDPRAVN---QDKKNILFSGTNVA----AGKAR-----------GVVIG 225
            |||||..:|.  .|..|| |.::   ..:.:::|.||.|.    ..||.           ..|:.
Human   353 TGESVPQMKEPIEDLSPD-RVLDLQADSRLHVIFGGTKVVQHIPPQKATTGLKPVDSGCVAYVLR 416

  Fly   226 TGLSTAIGK-IRTEMSETEEIKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWI 289
            ||.:|:.|| :||.:...:.:.          ...|...|.::.:.|:||       .|....||
Human   417 TGFNTSQGKLLRTILFGVKRVT----------ANNLETFIFILFLLVFAI-------AAAAYVWI 464

  Fly   290 KGA-------IYYFKIAVALAVAAIPEGLP-----AVITTCLALGTRRMAKKNAIVRSLPSVETL 342
            :|.       ...|.....:..:.:|..||     ||.|:.:||     ||..........:...
Human   465 EGTKDPSRNRYKLFLECTLILTSVVPPELPIELSLAVNTSLIAL-----AKLYMYCTEPFRIPFA 524

  Fly   343 GCTSVICSDKTGTLTTNQMSVSRMFIFDKVEG-NDSSFLEFEMTGSTYEPIGEVFLNGQRIKAAD 406
            |...|.|.|||||||::.:.|.      .|.| .|         |....|:..:.:...|..|:.
Human   525 GKVEVCCFDKTGTLTSDSLVVR------GVAGLRD---------GKEVTPVSSIPVETHRALASC 574

  Fly   407 YDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLA-------EKLNSFSVNKSGLDR 464
            :..:|        .:|..:           ||:..|.|::...       ||:...|:...||
Human   575 HSLMQ--------LDDGTL-----------VGDPLEKAMLTAVDWTLTKDEKVFPRSIKTQGL-- 618

  Fly   465 RSAAIACRGEIETKWKKEFTLEFSRDRKS-MSSYCTPLKASRLGTGPKLF---VKGAPE---GVL 522
                         |..:.|....:..|.| ::||      .:||:....:   ||||||   .:.
Human   619 -------------KIHQRFHFASALKRMSVLASY------EKLGSTDLCYIAAVKGAPETLHSMF 664

  Fly   523 ERC------THARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDS 581
            .:|      .|..:                        .|:..|.|||..         .:||..
Human   665 SQCPPDYHHIHTEI------------------------SREGARVLALGY---------KELGHL 696

  Fly   582 T-------KFYQYEVNLTFVGVVGMLDPPRKEVFDSIVR-CRAAGIRVIVITGDNKATAEAICRR 638
            |       |....|.:|.|||.: ::..|.|....:::| .:.|..||::|||||..||..:.:.
Human   697 THQQAREVKREALECSLKFVGFI-VVSCPLKADSKAVIREIQNASHRVVMITGDNPLTACHVAQE 760

  Fly   639 IGVFAEDEDT--------TGKSYSGREFDD--------------------------------LSP 663
            :. |.|...|        .|:....|..|.                                ..|
Human   761 LH-FIEKAHTLILQPPSEKGRQCEWRSIDGSIVLPLARGSPKALALEYALCLTGDGLAHLQATDP 824

  Fly   664 TEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAM-------- 720
            .:....:...::|:||.|:.|..::..|:.:..::.|.|||.||..|||.|::|:|:
Human   825 QQLLRLIPHVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLANAPERV 889

  Fly   721 --------------GSG-TAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSN-- 768
                          .|| .|.:::|.:.       |.:..:.|:..:..:.:.|.:|.|...:
Human   890 VERRRRPRDSPTLSNSGIRATSRTAKQR-------SGLPPSEEQPTSQRDRLSQVLRDLEDESTP 947

  Fly   769 ---IGEVVSIFLTAALGLP--EALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGL 828
               :|:       |::..|  ..|..:|.: .:::..|...                       |
Human   948 IVKLGD-------ASIAAPFTSKLSSIQCI-CHVIKQGRCT-----------------------L 981

  Fly   829 ISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSD 893
            ::....|:.:|:...:.|.:..      |...||.|.|.:|.|.....|.|        |.:|
Human   982 VTTLQMFKILALNALILAYSQS------VLYLEGVKFSDFQATLQGLLLAG--------CFLF-- 1030

  Fly   894 PHAMTMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHF---VILYVDVLST 955
                         |.....:.:||..:.|   |...||:.|.::.|.|.:||   |.||.:..:.
Human  1031 -------------ISRSKPLKTLSRERPL---PNIFNLYTILTVMLQFFVHFLSLVYLYREAQAR 1079

  Fly   956 VFQVTPLSAEEWITVMKFSIPVVLLDETLKFVARKIADGESPI-YK----MHGI----VLMWAVF 1011
                :|...|:::.:.|...| .|::.|:..:|..:......| ||    |..:    .|:|::.
Human  1080 ----SPEKQEQFVDLYKEFEP-SLVNSTVYIMAMAMQMATFAINYKGPPFMESLPENKPLVWSLA 1139

  Fly  1012 FGLL 1015
            ..||
Human  1140 VSLL 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	240/1136 (21%)
ATP13A1	NP_065143.2	P-ATPase-V	85..1173	CDD:273738	250/1174 (21%)
		A-domain, part 1. /evidence=ECO:0000250|UniProtKB:P39986	199..230		11/46 (24%)
		A-domain, part 2. /evidence=ECO:0000250|UniProtKB:P39986	295..435		44/152 (29%)
		E1-E2_ATPase	298..510	CDD:278548	62/245 (25%)
		P-domain, part 1. /evidence=ECO:0000250|UniProtKB:P39986	512..541		10/28 (36%)
		N-domain. /evidence=ECO:0000250|UniProtKB:P39986	543..724		49/269 (18%)
		Cation_ATPase	584..667	CDD:289987	23/114 (20%)
		HAD	643..873	CDD:289480	56/264 (21%)
		P-domain, part 2. /evidence=ECO:0000250|UniProtKB:P39986	727..885		36/158 (23%)
		COG4087	<831..>884	CDD:226572	18/52 (35%)
		Arm-like. /evidence=ECO:0000250|UniProtKB:P39986	886..949		9/69 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	889..933		6/50 (12%)
		P-domain, part 3. /evidence=ECO:0000250|UniProtKB:P39986	950..965		3/21 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910