DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and atp2a3

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	XP_697108.5	Gene:	atp2a3 / 568671	ZFINID:	ZDB-GENE-060531-103	Length:	1005	Species:	Danio rerio

Alignment Length:	995	Identity:	694/995 - (69%)
Similarity:	828/995 - (83%)	Gaps:	3/995 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65
            ||:.|:|:..:.|..||.:...||||:|:|.|..||||||||.|||||:|:||:|||:||||:||
Zfish     1 MENAHTKSASEVLANFGVNENTGLTLEQVKNNFDKYGPNELPAEEGKSLWELVVEQFEDLLVRIL 65

  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130
            ||||.:|||||||||.||:.||||||:||||||:||||:|||||||||:|||||||||||||||.
Zfish    66 LLAACVSFVLALFEEGEESTTAFVEPIVILLILVANAVIGVWQERNAENAIEALKEYEPEMGKVY 130

  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195
            |.:::.:|:::|::|||||:||:|||||:|||||||.|.|||||:|||||||||||||||||.:|
Zfish   131 RMNRTAVQRIKARDIVPGDIVEISVGDKVPADIRITSIKSTTLRVDQSILTGESVSVIKHTDPVP 195

  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260
            |||||||||||:||||||:|||:|.|||:.||:||.|||||.:|:.||:.||||||||||||:||
Zfish   196 DPRAVNQDKKNMLFSGTNIAAGRAIGVVVSTGVSTEIGKIRNQMAATEQEKTPLQQKLDEFGQQL 260

  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |||||:||:|||.||||||.||.||||||:|||||||||||||||||||||||||||||||||||
Zfish   261 SKVISLICIAVWVINIGHFADPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390
            ||||||||||||||||||||||||||||||||||||||.|||:.:|.:.:..|..||.::||||.
Zfish   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVNKADDSSCSLHEFTISGSTYA 390

  Fly   391 PIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455
            |.|||....::::..|||.|.||:|||.:||||::||||.|..:|||||||||||..|.||:|.|
Zfish   391 PEGEVLKADKQVQCGDYDGLVELATICSLCNDSSLDYNEAKGVYEKVGEATETALTTLVEKMNVF 455

  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEG 520
            ..:.|||.:...|.||...|....:|:|||||||||||||.||||   :...:..|:||||||||
Zfish   456 KTDLSGLSKVDRAAACNLIIRQLMQKKFTLEFSRDRKSMSVYCTP---NGTNSQSKMFVKGAPEG 517

  Fly   521 VLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFY 585
            |::||...|||..:.|||.|:|.::::....:|||||||||||||..|||...|:|||.::.||.
Zfish   518 VIDRCQFVRVGKERFPLTMAVKEELMSTIRDWGTGRDTLRCLALATRDSPPAVDKMDLENAGKFA 582

  Fly   586 QYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTG 650
            :||.:|||||.|||||||||||..||..|..||||||:||||||.||.|||||||:|:|:||..|
Zfish   583 EYESSLTFVGCVGMLDPPRKEVIGSIKLCNKAGIRVIMITGDNKGTAVAICRRIGIFSENEDVEG 647

  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715
            ::|:|||||||:|..|:.||.|:|.|:||||.||||||.:|||.:||:|||||||||||||||||
Zfish   648 RAYTGREFDDLAPEAQREAVKRARCFARVEPAHKSKIVAYLQSFDEITAMTGDGVNDAPALKKAE 712

  Fly   716 IGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAA 780
            |||||||||||||||:||||:|||||:||:|||||||||||||||||||||||:||||.|||||.
Zfish   713 IGIAMGSGTAVAKSASEMVLSDDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAI 777

  Fly   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVG 845
            |||||||||||||||||||||||||||||||||||||:||||...|.||||||||||:|||.|||
Zfish   778 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDKPPRNPKEPLISGWLFFRYLAIGGYVG 842

  Fly   846 AATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEML 910
            ..||.||.||::|.::||::|::||.|.:.|......|:|::|::|...:..||||||||||||.
Zfish   843 LGTVSAATWWYLFDEDGPQVSFYQLRHFMQCTEENPMFEGINCEVFESRYPTTMALSVLVTIEMF 907

  Fly   911 NAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSI 975
            ||:|||||||||:.||||.|:||:|::.||.:|||:||:|:.|..:||||||...:||.|.|.||
Zfish   908 NALNSLSENQSLLRMPPWVNIWLLGAIILSLSLHFLILHVEPLPLIFQVTPLHFSQWIIVFKISI 972

  Fly   976 PVVLLDETLKFVARKIADGE 995
            ||:||||.||:::|...:||
Zfish   973 PVILLDEALKYISRHHLEGE 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	689/983 (70%)
atp2a3	XP_697108.5	Cation_ATPase_N	4..72	CDD:279080	41/67 (61%)
		ATPase-IIA1_Ca	53..986	CDD:273452	662/935 (71%)
		E1-E2_ATPase	92..340	CDD:278548	202/247 (82%)
		Cation_ATPase	419..525	CDD:289987	62/108 (57%)
		HAD	<601..709	CDD:289480	75/107 (70%)
		Cation_ATPase_C	781..984	CDD:279079	133/202 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580855
Domainoid	1	1.000	353	1.000	Domainoid score	I959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1428	1.000	Inparanoid score	I114
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm24260
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	O	PTHR42861
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X745
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910