DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERCA and atp13a2

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_001073506.1	Gene:	atp13a2 / 568666	ZFINID:	ZDB-GENE-061215-126	Length:	1170	Species:	Danio rerio

Alignment Length:	965	Identity:	212/965 - (21%)
Similarity:	359/965 - (37%)	Gaps:	262/965 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ERGLTLDQIKANQKKYGPN--ELPTEEGKSIWQLVLEQ----------FDDLL---------VKI 64
            ::||:.......::.:|.|  ::|.   ||..||:.|:          |..:|         ...
Zfish   179 QQGLSRADQSTRKQIFGANIIDVPV---KSYLQLLFEEVLNPFYIFQVFSIILWMSDGYVYYAAC 240

  Fly    65 LLLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKV 129
            :.:.::||..::|:|..:::.|     |..:..||.|.                          .
Zfish   241 IFIISLISIGVSLYETRKQSTT-----LRRMACLIVNV--------------------------T 274

  Fly   130 VRQDKSGIQKVRAKEIVPGDLVEV-SVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIK---- 189
            ||:|....:.|.::|:||||.|.: :.|..:|.|..:.   :....:::|:|||||:.|:|
Zfish   275 VRRDTGEEECVSSEELVPGDCVVIPAEGLLLPCDAALV---AGECMVNESMLTGESIPVMKTPLS 336

  Fly   190 HTDAIPDPRAVNQDKKNILFSGTNVAAGKARG-------VVIGTGLSTAIGKIRTEMSETEEIKT 247
            :::|..:|.:   .:::.||.||.:...|..|       ||..||..||.|.:      ...|..
Zfish   337 NSEATYNPES---QRRHTLFCGTQIIQAKGGGPGKGAIAVVTCTGFLTAKGDL------ISSILY 392

  Fly   248 PLQQKLD-EFGEQLSK------VISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVA 305
            |  |.|| .|.....|      ::::|......:.:...|.|     |.:..|....|...:
Zfish   393 P--QPLDFRFYRDAMKFLLFLGLLALIGTIYSLVILSKSNTP-----WKELIIRSLDIVTII--- 447

  Fly   306 AIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFD 370
             :|..|||.|||.......|:.::.....|.|.:...|..|:.|.|||||||...:.|..:
Zfish   448 -VPPALPAAITTATIYAQNRLKRQGVFCISPPRINICGKISLFCFDKTGTLTEEGLDVWGV---- 507

  Fly   371 KVEGNDSSFLEFEMTGSTYEPIGE-----VFL-NGQRIKAADYDTLQELSTICIMCNDSAIDYNE 429
                       .|:||..:   ||     :|| .|..:.|     |....::.::...:..|..|
Zfish   508 -----------MEVTGGVF---GELVPDPLFLPPGLMLSA-----LASCHSVALLGGQALGDPLE 553

  Fly   430 FKQAFEKVG-EATE--------------TALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKW 479
            .|. .|..| |.||              ..|.|:....:......:.:.:..|.:
Zfish   554 LKM-IESTGWELTEPENDMGHDSEFGGHRVLAVMRPPASELLTEGNSVSQPVAIV---------- 607

  Fly   480 KKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAK 544
             :.|....|..|.|:.: ..|.:.|     |..|:|||||.|...| |..    .||...:...:
Zfish   608 -RRFPFSSSLQRMSVVT-VGPAEPS-----PVAFIKGAPEMVASFC-HKE----SVPSHFSHTLR 660

  Fly   545 ILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFD 609
            ..|..|        .|.|.||...   ...|.|| .:.:..:.|..:.|:|::.|.:..:.|..:
Zfish   661 EYASQG--------FRVLGLAYKH---LAKETDL-STVERVEVEKGMNFLGLLVMKNQVKPESAE 713

  Fly   610 SIVRCRAAGIRVIVITGDNKATAEAICRRIGV------------------------FAEDEDTTG 650
            .|.....|.:|.:::||||..||..:.|..|:                        |.|.|..|.
Zfish   714 VIQTLTLAQLRPVMVTGDNILTAVNVARVCGMVPLHEKVIFVHASPPTAGSQASLQFHEGEGATA 778

  Fly   651 KSYSGREFD--------------------------DLSPTEQKAAVARSRLFSRVEPQHKSKIVE 689
            ...:.:..|                          |..|......:.|..:::|:.|:.|:::|:
Zfish   779 TINTQQTIDIPVQGQYQSAVGYHLAINGMSFAALCDHFPEYLPKVLMRGTIYARMTPEQKTQLVK 843

  Fly   690 FLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGR--- 751
            .||.:|....|.|||.||..||:.|::|:::..  |.|..|:......||.|.:...::|||
Zfish   844 ALQKLNYRVGMCGDGANDCGALRAADVGVSLSD--AEASVASPFTSKSDNISCVPLLIKEGRCSL 906

  Fly   752 ----------AIYNNMKQF----IRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGL 802
                      |:| ::.||    |.|...:|:|::..:|..        |:.|.:|.: |:..|.
Zfish   907 VTSFSLFKYMALY-SLIQFASVLILYTEKTNLGDLQFLFFD--------LVLVTVLAI-LMGRGG 961

  Fly   803 PATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFV 857
            |:..|....|...::..|       :::..|....:.|...|....:..:..|:|
Zfish   962 PSNDLHPQRPAASLLSLP-------VLASLLMHTVLLILAQVSGLLITMSQDWYV 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	212/965 (22%)
atp13a2	NP_001073506.1	P5-ATPase	36..152	CDD:289194
		P-ATPase-V	42..1102	CDD:273738	212/965 (22%)
		Cation_ATPase_N	<179..229	CDD:279080	11/52 (21%)
		E1-E2_ATPase	241..478	CDD:278548	67/290 (23%)
		Cation_ATPase	<606..646	CDD:289987	14/56 (25%)
		HAD_like	<832..885	CDD:304363	20/54 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910