DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and atp2b3b

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	XP_021325490.1	Gene:	atp2b3b / 558525	ZFINID:	ZDB-GENE-080409-2	Length:	1297	Species:	Danio rerio

Alignment Length:	1129	Identity:	303/1129 - (26%)
Similarity:	480/1129 - (42%)	Gaps:	283/1129 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TDPE------RGLTLDQIKAN-------QKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAA 69
            ||.|      :..|.|.:..|       ::.:|.|.:|.::.|:..|||.|...|:.:.||.|||
Zfish    61 TDVEGLCQRLKSSTTDGLSDNPTDLEKRRQTFGQNFIPPKKPKTFLQLVWEALQDVTLIILELAA 125

  Fly    70 IISFVLALF-----------------EEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIE 117
            |||..|:.:                 |:..|....::|...|||.:|...:|..:.:.:.|....
Zfish   126 IISLALSFYQPPGEDSEVCGKGAGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFR 190

  Fly   118 ALK---EYEPEMGKVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSI 179
            .|:   |.|.... |||  ...:.::...|:|.||:.:|..||.:|||..:  :....|:||:|.
Zfish   191 GLQSRIELEQRFA-VVR--NGNVIQIPVAEMVVGDMAQVKYGDLLPADGVL--VQGNDLKIDESS 250

  Fly   180 LTGESVSVIKHTDAIPDPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRT------- 237
            |||||..|.|..:..|           :|.|||:|..|..|.:|...|:::..|.|.|
Zfish   251 LTGESDHVRKSVEKDP-----------MLLSGTHVMEGSGRMLVTAVGVNSQSGIIFTLLGAGEG 304

  Fly   238 ----------------------------------------EMSETEE-----------IKTPLQQ 251
                                                    |..|.||           .|:.||.
Zfish   305 EEEKKEKKGKQPEAAVETNQNKAKKQDGAVAMEMQPLKSAEGGEVEEREKKKANVPKKEKSVLQG 369

  Fly   252 KLDEFGEQLSK---VISVICVAVWAIN-------IGHFNDPAHGGSWIKGA--IY------YFKI 298
            ||.:...|:.|   |:|.|.|.:..:.       :|:.       :|:...  ||      :|.|
Zfish   370 KLTKLAVQIGKAGLVMSAITVIILVLYFVIDTFVVGNM-------TWLPECTPIYVQYFVKFFII 427

  Fly   299 AVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSV 363
            .|.:.|.|:|||||..:|..||...::|.|.|.:||.|.:.||:|..:.||||||||||||:|:|
Zfish   428 GVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV 492

  Fly   364 SRMFIFDKVEGNDSSFLEF----EMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSA 424
            .:.:|      ||..|.|.    :::.:|.|.|    :|...|..|        .|..||..|
Zfish   493 VQSYI------NDQHFREIPDPSQISPNTLEMI----VNAISINCA--------YTSKIMPPD-- 537

  Fly   425 IDYNEFKQAFEKVGEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEI-ETKWKKEFTLEFS 488
            ::....||    ||..||..|:...            ||.:......|.:| |.|..|.:|  |:
Zfish   538 VEGGLPKQ----VGNKTECGLLGFL------------LDLKRDYAPVREQIPEEKLYKVYT--FN 584

  Fly   489 RDRKSMSSYCTPLKASRLGTGP-KLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY 552
            ..|||||:      ..::..|. :|:.|||.|.||::|                 :.||...|:.
Zfish   585 SVRKSMST------VVQMPDGSFRLYSKGASEIVLKKC-----------------SSILGTNGEA 626

  Fly   553 GTGR-----------------DTLRCLALAVADSPMKPDEMDLGDSTKFYQYE----VNLTFVGV 596
            ...|                 :.||.:.:...|.|        ||....::.|    .:||.:.|
Zfish   627 RNFRPRDRDEMVKKVIEPMACEGLRTICIGYRDLP--------GDPEPEWENEAEIVTDLTCIAV 683

  Fly   597 VGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDED---TTGKSYSGREF 658
            ||:.||.|.||.|:|.:|:.|||.|.::||||..||.||..:.|:....:|   ..||.::.|..
Zfish   684 VGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARAIASKCGIIQPGDDFLCLEGKDFNRRIR 748

  Fly   659 DDLSPTEQK---AAVARSRLFSRVEPQHKSKIVE-----FLQSMNEISAMTGDGVNDAPALKKAE 715
            ::....||:   ....:.|:.:|..|..|..:|:     .:....::.|:||||.||.||||||:
Zfish   749 NEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVLEQRQVVAVTGDGTNDGPALKKAD 813

  Fly   716 IGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTA 779
            :|.||| :||.|||.|::::|.||||||||.||..||.:|:::.:|:::.::.|:..|:..|..|
Zfish   814 VGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGA 878

  Fly   780 ALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYV 844
            .:.....|..||:|||||:.|...:.||...||...::.:.|...:..|||..:....:..|.|
Zfish   879 CITQDSPLKAVQMLWVNLIMDTFASLALATEPPTEALLLRKPYGRNNPLISLTMMKNILGHGVY- 942

  Fly   845 GAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHA-----MTMALSVL 904
                                    ||....:.|..|::...:|...::..|:     .|:..:..
Zfish   943 ------------------------QLVIIFTLLFVGEKIFNIDSGRYAQLHSPPSEHYTIIFNTF 983

  Fly   905 VTIEMLNAMNSLSEN------QSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLS 963
            |.:::.|.:|:...:      ..:...|.:|:: ::|:..:.      ::.|......|...||:
Zfish   984 VLMQLFNEINARKIHGERNVFDGIFANPIFCSI-VLGTFGVQ------VVIVQFGGKPFSCAPLN 1041

  Fly   964 AEEWITVMKFSIPVVLLDETLKFV 987
            .|:|:..:...:..:|..:.:..|
Zfish  1042 VEQWLWCLFVGVGELLWGQVIATV 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	303/1129 (27%)
atp2b3b	XP_021325490.1	E1-E2_ATPase	27..1068	CDD:332568	303/1129 (27%)
atp2b3b	XP_021325490.1	ATP_Ca_trans_C	1107..1191	CDD:315156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010