Protein Alignment SERCA and ATP2B2

DIOPT Version :9

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: XP_016861981.1
• Gene: ATP2B2 / 491
• HGNCID: 815
• Length: 1272
• Species: Homo sapiens
• Alignment Length: 1163
• Identity: 300/1163 - (25%)
• Similarity: 469/1163 - (40%)
• Gaps: 318/1163 - (27%)

  Fly    18 TDPERGL--TLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALF-- 78
            |.|..||  |...::..::.:|.|.:|.::.|:..|||.|...|:.:.||.:|||||..|:.:
Human    62 TSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP 126

  Fly    79 ---------------EEHEETFTAFVEPLVILLILIANAVVGV---W----QERNAESAIEALKE 121
                           |:..|....::|...|||.:|...:|..   |    |.|..:|.||..::
Human   127 PGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQK 191

  Fly   122 YEPEMGKVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVS 186
            :     .|||..:  :.::...|||.||:.:|..||.:|||  ...|....|:||:|.|||||..
Human   192 F-----TVVRAGQ--VVQIPVAEIVVGDIAQVKYGDLLPAD--GLFIQGNDLKIDESSLTGESDQ 247

  Fly   187 VIKHTDAIPDPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKI---------------- 235
            |.|..|..|           :|.|||:|..|..|.:|...|:::..|.|
Human   248 VRKSVDKDP-----------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDK 301

  Fly   236 ----------------------------------------------------------------- 235
                                                                             
Human   302 KGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAE 366

  Fly   236 ------RTEMSETEEIKTPLQQKLDEFGEQLSK---VISVICVAVWAINIGHFNDPAHGGSW--- 288
                  |.:.|..::.|:.||.||.:...|:.|   |:|.|.|.:..:.........:...|
Human   367 GGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPE 431

  Fly   289 -----IKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVI 348
                 ::..:.:|.|.|.:.|.|:|||||..:|..||...::|.|.|.:||.|.:.||:|..:.|
Human   432 CTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAI 496

  Fly   349 CSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTLQEL 413
            |||||||||||:|:|.:.::      .|..:.|.....|......|:.:|...|.:| |.|
Human   497 CSDKTGTLTTNRMTVVQAYV------GDVHYKEIPDPSSINTKTMELLINAIAINSA-YTT---- 550

  Fly   414 STICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEI-ET 477
             .|.....:.|:.        .:||..||..|:...            ||.:......|.:: |.
Human   551 -KILPPEKEGALP--------RQVGNKTECGLLGFV------------LDLKQDYEPVRSQMPEE 594

  Fly   478 KWKKEFTLEFSRDRKSMSSYC-TPLKASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPLTSAL 541
            |..|.:|  |:..|||||:.. .|.::.|      ::.|||.|.||::|
Human   595 KLYKVYT--FNSVRKSMSTVIKLPDESFR------MYSKGASEIVLKKC---------------- 635

  Fly   542 KAKILALTGQYGTGR-----------------DTLRCLALAVADSPMKPDEMDLGDSTKFYQYEV 589
             .|||...|:....|                 |.||.:.:|..|.|..| |.|..:......
Human   636 -CKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSP-EPDWDNENDILN--- 695

  Fly   590 NLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDED---TTGK 651
            .||.:.|||:.||.|.||.::|.:|:.|||.|.::||||..||.||..:.|:....||   ..||
Human   696 ELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGK 760

  Fly   652 SYSGREFDDLSPTEQK---AAVARSRLFSRVEPQHKSKIVEFL-----QSMNEISAMTGDGVNDA 708
            .::.|..::....||:   ....:.|:.:|..|..|..:|:.:     ....::.|:||||.||.
Human   761 EFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDG 825

  Fly   709 PALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEV 772
            ||||||::|.||| :||.|||.|::::|.||||||||.||..||.:|:::.:|:::.::.|:..|
Human   826 PALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAV 890

  Fly   773 VSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRY 837
            :..|..|.:.....|..||:|||||:.|...:.||...||...::.:.|...::.|||..:....
Human   891 IVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNI 955

  Fly   838 MAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEF----KGVDCKIFSDP-HAM 897
            :....|                         ||....:.|..|::.    .|.:..:.|.| ...
Human   956 LGHAVY-------------------------QLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHY 995

  Fly   898 TMALSVLVTIEMLNAMNSLSEN------QSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTV 956
            |:..:..|.:::.|.:|:...:      ..:...|.:|.: ::|:.|:.      |:.|......
Human   996 TIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTI-VLGTFAIQ------IVIVQFGGKP 1053

  Fly   957 FQVTPLSAEEWITVMKFSIPVVLLDETLKFVARKIADGESPIYKMHGIVLMWAVFFGL 1014
            |..:||..::|                                       ||.:|.||
Human  1054 FSCSPLQLDQW---------------------------------------MWCIFIGL 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	295/1136 (26%)
ATP2B2	XP_016861981.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920