Protein Alignment SERCA and ATP2B1

DIOPT Version :9

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_001353453.1
• Gene: ATP2B1 / 490
• HGNCID: 814
• Length: 1249
• Species: Homo sapiens
• Alignment Length: 1161
• Identity: 307/1161 - (26%)
• Similarity: 477/1161 - (41%)
• Gaps: 325/1161 - (27%)

  Fly    18 TDPERGLTLD--QIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALF-- 78
            |.|..||:.:  .::..:..:|.|.:|.::.|:..|||.|...|:.:.||.:|||:|..|:.:
Human    65 TSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQP 129

  Fly    79 --------------EEHEETFTAFVEPLVILLILIANAVVGV---W----QERNAESAIEALKEY 122
                          ||..|..|.::|...|||.::...:|..   |    |.|..:|.||..:::
Human   130 PEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKF 194

  Fly   123 EPEMGKVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSV 187
            ....|..|.|       :...:|..||:.:|..||.:|||..:  |....|:||:|.|||||..|
Human   195 TVIRGGQVIQ-------IPVADITVGDIAQVKYGDLLPADGIL--IQGNDLKIDESSLTGESDHV 250

  Fly   188 IKHTDAIPDPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEM---SETEE----- 244
            .|           :.||..:|.|||:|..|..|.||...|:::..|.|.|.:   .|.||
Human   251 KK-----------SLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEK 304

  Fly   245 -----------------------------------------------------IKTPLQQKLDEF 256
                                                                 .|:.||.||.:.
Human   305 KKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKL 369

  Fly   257 GEQLSK------VISVICVAVWAINIGHFNDPAHGGSWIK--------GAIY------YFKIAVA 301
            ..|:.|      .|:||.:.::.: |..|        |::        ..||      :|.|.|.
Human   370 AVQIGKAGLLMSAITVIILVLYFV-IDTF--------WVQKRPWLAECTPIYIQYFVKFFIIGVT 425

  Fly   302 LAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRM 366
            :.|.|:|||||..:|..||...::|.|.|.:||.|.:.||:|..:.||||||||||.|:|:|.:.
Human   426 VLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQA 490

  Fly   367 FIFDK-------VEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSA 424
            :|.:|       .|....:.|.:.:||                          :|..|  ...|.
Human   491 YINEKHYKKVPEPEAIPPNILSYLVTG--------------------------ISVNC--AYTSK 527

  Fly   425 IDYNEFKQAFEK-VGEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEI-ETKWKKEFTLEF 487
            |...|.:....: ||..||.||:.|.            ||.:......|.|| |....|.:|  |
Human   528 ILPPEKEGGLPRHVGNKTECALLGLL------------LDLKRDYQDVRNEIPEEALYKVYT--F 578

  Fly   488 SRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY 552
            :..|||||   |.||.|  ....::|.|||.|.:|::|                 .|||:..|:.
Human   579 NSVRKSMS---TVLKNS--DGSYRIFSKGASEIILKKC-----------------FKILSANGEA 621

  Fly   553 GTGR-----------------DTLRCLALAVADSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGML 600
            ...|                 :.||.:.||..|.|....|.:..:.....   ..||.:.|||:.
Human   622 KVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIV---TGLTCIAVVGIE 683

  Fly   601 DPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDED---TTGKSYSGREFDDLS 662
            ||.|.||.|:|.:|:.|||.|.::||||..||.||..:.|:....||   ..||.::.|..::..
Human   684 DPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKG 748

  Fly   663 PTEQK---AAVARSRLFSRVEPQHKSKIVE-----FLQSMNEISAMTGDGVNDAPALKKAEIGIA 719
            ..||:   ....:.|:.:|..|..|..:|:     .:....::.|:||||.||.||||||::|.|
Human   749 EIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFA 813

  Fly   720 MG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGL 783
            || :||.|||.|::::|.||||:|||.||..||.:|:::.:|:::.::.|:..|:..|..|.:..
Human   814 MGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQ 878

  Fly   784 PEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVGAAT 848
            ...|..||:|||||:.|.|.:.||...||...::.:.|...::.|||..:....:...||
Human   879 DSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFY----- 938

  Fly   849 VGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHA-----MTMALSVLVTIE 908
                                ||....:.|..|::|..:|....:..||     .|:..:..|.::
Human   939 --------------------QLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQ 983

  Fly   909 MLNAMNSLSEN------QSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEW 967
            :.|.:|:...:      :.:.....:|.: ::|:..:.      |:.|......|..:.||.|:|
Human   984 LFNEINARKIHGERNVFEGIFNNAIFCTI-VLGTFVVQ------IIIVQFGGKPFSCSELSIEQW 1041

  Fly   968 ITVMKFSIPVVLLDETLKFVARKIADGESPIYKMHGIVLMWAVFFG---LLYAMML 1020
                                                   :|::|.|   ||:..::
Human  1042 ---------------------------------------LWSIFLGMGTLLWGQLI 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	302/1125 (27%)
ATP2B1	NP_001353453.1	ATPase-IIB_Ca	15..1064	CDD:273668	307/1161 (26%)
		ATP_Ca_trans_C	1103..1178	CDD:403580

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920