Protein Alignment SERCA and ATP2A1

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_775293.1
• Gene: ATP2A1 / 487
• HGNCID: 811
• Length: 1001
• Species: Homo sapiens
• Alignment Length: 989
• Identity: 711/989 - (71%)
• Similarity: 827/989 - (83%)
• Gaps: 0/989 - (0%)

  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65
            ||..|:||.|:.|.:||.....|||.||:|.|.:|||.||||.||||::|:||:|||:||||:||
Human     1 MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRIL 65

  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130
            ||||.||||||.|||.|||.||||||.||||||||||:||||||||||:|||||||||||||||.
Human    66 LLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVY 130

  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195
            |.|:..:|:::|::|||||:|||:||||:||||||..|.|||||:||||||||||||||||:.:|
Human   131 RADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVP 195

  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260
            |||||||||||:||||||:|||||.|:|..||:.|.|||||.:|:.||:.|||||||||||||||
Human   196 DPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQL 260

  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |||||:||||||.|||||||||.|||||.:|||||||||||||||||||||||||||||||||||
Human   261 SKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390
            ||||||||||||||||||||||||||||||||||||||.:|||.|||:|:.....||.:|||||.
Human   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYA 390

  Fly   391 PIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455
            |.|||..|.:.::...||.|.||:|||.:||||::|:||.|..:|||||||||||..|.||:|.|
Human   391 PEGEVLKNDKPVRPGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVF 455

  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEG 520
            :.:...|.:...|.||...|....||||||||||||||||.||:|.|:||...|.|:||||||||
Human   456 NTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEG 520

  Fly   521 VLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFY 585
            |::||.:.|||||:||||..:|.||:|:..::|||||||||||||..|:|.|.:||.|.||.:|.
Human   521 VIDRCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFL 585

  Fly   586 QYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTG 650
            :||.:|||||||||||||||||..||..||.||||||:||||||.||.|||||||:|.|:|:...
Human   586 EYETDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVAD 650

  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715
            ::|:|||||||...||:.|..|:..|:||||.|||||||:|||.:||:|||||||||||||||||
Human   651 RAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAE 715

  Fly   716 IGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAA 780
            |||||||||||||:|:||||||||||:||:|||||||||||||||||||||||:||||.||||||
Human   716 IGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA 780

  Fly   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVG 845
            |||||||||||||||||||||||||||||||||||||::|||...|.||||||||||||||.|||
Human   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVG 845

  Fly   846 AATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEML 910
            |||||||||||:::::||.::|.||||.:.|......|:|:||::|..|..|||||||||||||.
Human   846 AATVGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIEMC 910

  Fly   911 NAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSI 975
            ||:|||||||||:.||||.|:||:||:.||.:|||:|||||.|..:|::..|...:|:.|:|.|:
Human   911 NALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWLMVLKISL 975

  Fly   976 PVVLLDETLKFVAR 989
            ||:.|||.||||||
Human   976 PVIGLDEILKFVAR 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	707/983 (72%)
ATP2A1	NP_775293.1	P-type_ATPase_SERCA	5..989	CDD:319778	707/983 (72%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	788..808		19/19 (100%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	932..943		6/10 (60%)