DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and ATP1A1

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_000692.2	Gene:	ATP1A1 / 476	HGNCID:	799	Length:	1023	Species:	Homo sapiens

Alignment Length:	1086	Identity:	325/1086 - (29%)
Similarity:	516/1086 - (47%)	Gaps:	206/1086 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLL 67
            |.|..::::....:|||..||||..:......:.|||.|........|.....|.......:|.:
Human    42 DDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWI 106

  Fly    68 AAIISF----VLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGK 128
            .||:.|    :.|..||..:....:: .:|:..::|.......:||..:...:|:.|...|:...
Human   107 GAILCFLAYSIQAATEEEPQNDNLYL-GVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQAL 170

  Fly   129 VVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDA 193
            |:|..:.  ..:.|:|:|.||||||..||:||||:||  |.:...::|.|.|||||....:
Human   171 VIRNGEK--MSINAEEVVVGDLVEVKGGDRIPADLRI--ISANGCKVDNSSLTGESEPQTR---- 227

  Fly   194 IPDPRAVNQ---DKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDE 255
              .|...|:   :.:||.|..||...|.|||:|:.||..|.:|:|.|..|..|..:||:..:::.
Human   228 --SPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEH 290

  Fly   256 FGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLA 320
            |...::.|...:.|:.:.:::      ....:|::..|:    .:.:.||.:||||.|.:|.||.
Human   291 FIHIITGVAVFLGVSFFILSL------ILEYTWLEAVIF----LIGIIVANVPEGLLATVTVCLT 345

  Fly   321 LGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDS----SFLE 381
            |..:|||:||.:|::|.:|||||.||.||||||||||.|:|:|:.|:..:::...|:    |.:.
Human   346 LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVS 410

  Fly   382 FEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNE-----FKQAFEKVGEAT 441
            |:.|.:|:                     ..||.|..:||.:....|:     .|:|.  .|:|:
Human   411 FDKTSATW---------------------LALSRIAGLCNRAVFQANQENLPILKRAV--AGDAS 452

  Fly   442 ETALIVLAEKLNSFSVNKSGLDRRSAAIACRG---EIETKWKKEFTLEF-SRDRKSMSSYCTPLK 502
            |:||:...|                   .|.|   |:..::.|...:.| |.::..:|.:..|..
Human   453 ESALLKCIE-------------------LCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNT 498

  Fly   503 ASRLGTGPK--LFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY----GTGRDTLRC 561
            :.     |:  |.:|||||.:|:||:...:...:.||...||.   |....|    |.|...|..
Human   499 SE-----PQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKD---AFQNAYLELGGLGERVLGF 555

  Fly   562 LALAVADSPMKPDEMDLGDSTKFYQYEV--------NLTFVGVVGMLDPPRKEVFDSIVRCRAAG 618
            ..|.:      |||    ...:.:|::.        ||.|||::.|:||||..|.|::.:||:||
Human   556 CHLFL------PDE----QFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAG 610

  Fly   619 IRVIVITGDNKATAEAICRRIGVFAEDEDTTGKSYSGR---EFDDLSPTEQKAAVARSR------ 674
            |:||::|||:..||:||.:.:|:.:|..:|. :..:.|   ....::|.:.||.|....
Human   611 IKVIMVTGDHPITAKAIAKGVGIISEGNETV-EDIAARLNIPVSQVNPRDAKACVVHGSDLKDMT 674

  Fly   675 --------------LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGT 724
                          :|:|..||.|..|||..|....|.|:|||||||:||||||:||:||| :|:
Human   675 SEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGS 739

  Fly   725 AVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVS--IFLTAALGLPEAL 787
            .|:|.||:|:|.||||:|||:.|||||.|::|:|:.|.|.::|||.|:..  ||:.|.:.||  |
Human   740 DVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLP--L 802

  Fly   788 IPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPR--KAD----EGLIS------GWL-----FF 835
            ..|.:|.::|.||.:||.:|.:...:.|||::.||  |.|    |.|||      |.:     ||
Human   803 GTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFF 867

  Fly   836 RYMAI----GFYVGAATVGAAAWW------FVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKI 890
            .|..|    || :....:|....|      .|....|.:.:|             ::.|.|:
Human   868 TYFVILAENGF-LPIHLLGLRVDWDDRWINDVEDSYGQQWTY-------------EQRKIVE--- 915

  Fly   891 FSDPHAMTMALSVLVTIEML---NAMNSL----SENQSLITMPPWCNLWLIGSMALSFTLHFVIL 948
            |:...|..:::.|:...:::   ...||:    .:|:.||       ..|....||:..|.
Human   916 FTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILI-------FGLFEETALAAFLS---- 969

  Fly   949 YVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLDETLKFVARKIADG 994
            |...:....::.||....|.....:|:.:.:.||..|.:.|:...|
Human   970 YCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGG 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	322/1077 (30%)
ATP1A1	NP_000692.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		ATPase-IIC_X-K	30..1023	CDD:273445	325/1086 (30%)
		Phosphoinositide-3 kinase binding. /evidence=ECO:0000250	82..84		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..235		8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930