Protein Alignment SERCA and PMCA

DIOPT Version :9

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Alignment Length: 1105
• Identity: 293/1105 - (26%)
• Similarity: 478/1105 - (43%)
• Gaps: 224/1105 - (20%)

  Fly    18 TDPERGLTLDQIKANQKK--YGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFE- 79
            |.|..||:..:.....::  :|.|.:|.:..|:...||.|...|:.:.||.:||::|..|:.::
  Fly    48 TSPNEGLSGSKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKP 112

  Fly    80 --------EHEETFTAFVEPLVILLILIANAVVGVW-------QERNAESAIEALKEYEPEMGKV 129
                    :.||....::|.|.||:.:|...:|..:       |.|..::.||...::....|..
  Fly   113 ADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGE 177

  Fly   130 VRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAI 194
            |.|...|       :|:.||:.:|..||.:|||..:  |.|..|::|:|.|||||..|.|..|..
  Fly   178 VCQISVG-------DILVGDIAQVKYGDLLPADGCL--IQSNDLKVDESSLTGESDHVKKGPDVD 233

  Fly   195 PDPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIG------------------KIRTEMSE 241
            |           ::.|||:|..|..:.||...|:::..|                  |::.|...
  Fly   234 P-----------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKR 287

  Fly   242 -----------------------------TEEI--------------------------KTPLQQ 251
                                         |.||                          |:.||.
  Fly   288 ANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQA 352

  Fly   252 KLDEFGEQLSKVISVICVAVWAINIGHF-------NDPAHGGSWIKGAIYYFKIAVALAVAAIPE 309
            ||.:...|:....|.|.|....|.|..|       ::.....::....:.:..|.|.:.|.|:||
  Fly   353 KLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPE 417

  Fly   310 GLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEG 374
            |||..:|..||...::|.|.|.:||.|.:.||:|..:.||||||||||||:|:|.:.:|.:|:
  Fly   418 GLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKL-- 480

  Fly   375 NDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGE 439
                ...........:.:|.:...|..:.:|        .|..||...:..|..      .:||.
  Fly   481 ----CKVLPTLSDIPQHVGNLITMGISVNSA--------YTSNIMAGHNPGDLP------IQVGN 527

  Fly   440 ATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEI-ETKWKKEFTLEFSRDRKSMSSYCTPLKA 503
            .||.||:...:.|        |:..:|    .|.|| |.|:.:.:|  |:..||||.:.     .
  Fly   528 KTECALLGFVQGL--------GVKYQS----IRDEITEDKFTRVYT--FNSVRKSMGTV-----I 573

  Fly   504 SRLGTGPKLFVKGAPEGVLERCT--HARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAV 566
            .|...|.:|:.|||.|.::::|.  :...||.: ..|..::.:::....: ....|.||.:::|.
  Fly   574 PRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLE-KFTRDMQERLIREVIE-PMACDGLRTISVAY 636

  Fly   567 AD-SPMKP--DEMDLGDSTKFYQYE---VNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVIT 625
            .| .|.|.  :|:.:.....:...|   .|||.:.|||:.||.|.||.|:|.:|:.|||.|.::|
  Fly   637 RDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVT 701

  Fly   626 GDNKATAEAICRRIGVFAEDED---TTGKSYSGREFDDLSPTEQ---KAAVARSRLFSRVEPQHK 684
            |||..||.:|..:.|:...::|   ..||.::.|..|.....:|   .....:.|:.:|..|..|
  Fly   702 GDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDK 766

  Fly   685 SKIVE-----FLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSI 743
            ..:|:     .:....|:.|:||||.||.||||||::|.||| :||.|||.|::::|.|||||||
  Fly   767 YTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSI 831

  Fly   744 VSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALG 808
            |.||..||.:|:::.:|:::.::.|:..|:..|:.|.......|..||:|||||:.|.|.:.||.
  Fly   832 VKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALA 896

  Fly   809 FNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFY-----VGAATVGAAAWWFVFSDEGPKLSYW 868
            ...|..|::.:.|....:.|||..:....:....|     .|...||..    :...|.
  Fly   897 TEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDV----ILDIES------ 951

  Fly   869 QLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSEN------QSLITMPP 927
                     |.|.|......:.|      |:..:..|.:.:.|.:|:...:      :.|:|.|.
  Fly   952 ---------GRGQELNAGPTQHF------TIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPI 1001

  Fly   928 WCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLDETLKFV-ARKI 991
            :..:|:       ||:...:|.:......|....|:.::|:..:.|.|..::..:.:..| .||:
  Fly  1002 FYTIWI-------FTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKL 1059

  Fly   992  991
              Fly  1060  1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	291/1101 (26%)
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	291/1101 (26%)
		Cation_ATPase_N	36..104	CDD:279080	16/55 (29%)
		E1-E2_ATPase	172..448	CDD:278548	71/295 (24%)
		Cation_ATPase	505..598	CDD:289987	33/125 (26%)
		HAD_like	676..807	CDD:119389	46/130 (35%)
		Cation_ATPase_C	873..1051	CDD:279079	43/209 (21%)
		ATP_Ca_trans_C	1096..1142	CDD:289209

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840