DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and atp2b1a

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	XP_021330641.1	Gene:	atp2b1a / 378746	ZFINID:	ZDB-GENE-030925-29	Length:	1266	Species:	Danio rerio

Alignment Length:	1092	Identity:	307/1092 - (28%)
Similarity:	465/1092 - (42%)	Gaps:	274/1092 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALF--------------- 78
            |:..:..:|.|.:|.::.|:..|||.|...|:.:.||.:|||:|..|:.:
Zfish    73 IEKRKAAFGQNFIPPKKPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYKPPDAGDKNCVKGTG 137

  Fly    79 -EEHEETFTAFVEPLVILLILIANAVVGV---W----QERNAESAIEALKEYEPEMGKVVRQDKS 135
             |..||..|.::|...|||.::...:|..   |    |.|..:|.||..:::....|..|.|
Zfish   138 GEPEEEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFSVVRGGQVIQ--- 199

  Fly   136 GIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAV 200
                :...|||.||:.::..||.:|||..:  |....|:||:|.|||||..|.|
Zfish   200 ----IHVAEIVVGDIAQIKYGDLLPADGIL--IQGNDLKIDESSLTGESDHVKK----------- 247

  Fly   201 NQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRT---------------------------- 237
            :.||..:|.|||:|..|..:.||...|:::..|.|.|
Zfish   248 SLDKDAMLLSGTHVMEGSGKIVVTAVGVNSQTGIIFTLLGAGEDDDDEEEKEKKKEKERKKEKKN 312

  Fly   238 -----------------------------EMSETEE---------IKTPLQQKLDEFGEQLSK-- 262
                                         |.::.||         .|:.||.||.:...|:.|
Zfish   313 KKQDGSVENRKKAKAQDGAAMEMQPLNSDEGADGEEKRKANLPKKEKSVLQGKLTKLAVQIGKAG 377

  Fly   263 ----VISVICVAV-------WAINIGHFNDPAHGGS---WIKGAIYYFKIAVALAVAAIPEGLPA 313
                .|:||.:.|       |...|     |...|.   :|:..:.:|.|.|.:.|.|:|||||.
Zfish   378 LLMSAITVIILVVLFVVDTFWVDKI-----PWDSGCIPIYIQFFVKFFIIGVTVLVVAVPEGLPL 437

  Fly   314 VITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSS 378
            .:|..||...::|.|.|.:||.|.:.||:|..:.||||||||||.|:|:|.::||.||
Zfish   438 AVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQVFIADK------- 495

  Fly   379 FLEFEMTGSTYEPIGEVFLNGQRIKAADYDTL-QELSTIC-----IMCNDSAIDYNEFKQAFEKV 437
                     .|..:.|..:    :.|:..|.| ..:|..|     ||..:.....|      .:|
Zfish   496 ---------HYRKVPEPDV----VPASTMDLLIVGISVNCAYTTKIMSPEKEGGLN------RQV 541

  Fly   438 GEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEI-ETKWKKEFTLEFSRDRKSMSSYCTPL 501
            |..||.||:..|            ||.:....|.|.|| |.|..|.:|  |:..|||||   |.|
Zfish   542 GNKTECALLGFA------------LDLKKDYQAVRNEIPEEKLYKVYT--FNSVRKSMS---TVL 589

  Fly   502 KASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGR---------- 556
            |..  ....::|.|||.|.:|::|                 .|||..||:....|
Zfish   590 KND--DGSYRMFSKGASEILLKKC-----------------FKILTSTGEAKVFRPRDRDDMVKR 635

  Fly   557 -------DTLRCLALAVADSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRC 614
                   :.||.:.||..|.|....|.|..:.....   ..||.|.|||:.||.|.||.|:|.:|
Zfish   636 VIEPMASEGLRTICLAYRDFPASEGEPDWDNEADIL---TRLTCVCVVGIEDPVRPEVPDAIRKC 697

  Fly   615 RAAGIRVIVITGDNKATAEAICRRIGVFAEDED---TTGKSYSGREFDDLSPTEQK---AAVARS 673
            :.|||.|.::||||..||.||..:.|:....:|   ..||.::.|..::....||:   ....:.
Zfish   698 QRAGITVRMVTGDNLNTARAIATKCGILQVGDDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKL 762

  Fly   674 RLFSRVEPQHKSKIVE-----FLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAE 732
            |:.:|..|..|..:|:     .:....::.|:||||.||.||||||::|.||| :||.|||.|::
Zfish   763 RVLARSSPTDKHTLVKGIIDSTVVEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASD 827

  Fly   733 MVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNL 797
            ::|.||||||||.||..||.:|:::.:|:::.::.|:..|:..|..|.:.....|..||:|||||
Zfish   828 IILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNL 892

  Fly   798 VTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEG 862
            :.|.|.:.||...||...::.:.|...::.|||..:....:....|
Zfish   893 IMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAVY------------------- 938

  Fly   863 PKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHA-----MTMALSVLVTIEMLNAMNSLSEN--- 919
                  ||....:.|..|::...:|...::|.||     .|:..:..|.:::.|.:|:...:
Zfish   939 ------QLIIIFTLLFAGEKMFNIDSGRYADLHAPPSEHYTIVFNTFVMMQLFNEINARKIHGER 997

  Fly   920 ---QSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWI 968
               :.:.....:|.: :.|    :|.:..||  |......|....|:.|:|:
Zfish   998 NVFEGIFNNMIFCTI-VFG----TFVIQIVI--VQFGGKPFSCVGLNIEQWL 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	307/1092 (28%)
atp2b1a	XP_021330641.1	E1-E2_ATPase	10..1064	CDD:332568	307/1092 (28%)
atp2b1a	XP_021330641.1	ATP_Ca_trans_C	1105..1191	CDD:315156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010