Protein Alignment SERCA and Atp13a2

DIOPT Version :9

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: XP_006239308.1
• Gene: Atp13a2 / 362645
• RGDID: 1307977
• Length: 1173
• Species: Rattus norvegicus
• Alignment Length: 1166
• Identity: 235/1166 - (20%)
• Similarity: 401/1166 - (34%)
• Gaps: 389/1166 - (33%)

  Fly    23 GLTLDQIKANQKKYGPN--ELPTEEGKSIWQLVLEQ----------FDDLL----------VKIL 65
            ||:|......:..||||  .:|.   ||..||::::          |...|          |.|.
  Rat   198 GLSLQDQAVRKTIYGPNVIGIPV---KSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIF 259

  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130
            |::| ||..|:|::..:::.|  :..:|.|.:.:.....|..:|
  Rat   260 LISA-ISICLSLYKTRKQSMT--LRDMVKLSVRVQVCRPGGEEE--------------------- 300

  Fly   131 RQDKSGIQKVRAKEIVPGD-LVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAI 194
                    .|.:.|:|||| ||....|..:|.|..:.   :....:::|.|||||:.|:|  .|:
  Rat   301 --------WVDSSELVPGDCLVLPQEGGMMPCDAALV---AGECVVNESSLTGESIPVLK--TAL 352

  Fly   195 PD---PRAVNQDKKNILFSGTNVAAGKA------RGVVIGTGLSTAIGKIRTEMSETEEIKTPLQ 250
            |:   |......:::.||.||.|...:|      ..||..||..||.|.:.:.:....    |:.
  Rat   353 PEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTRTGFCTAKGGLVSSILHPR----PIS 413

  Fly   251 QKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKI--------------AVA 301
            .|......:....:||:.                    :.|.||...|              |:.
  Rat   414 FKFYRHSMKFVAALSVLA--------------------LLGTIYSIIILYRNRVPVKEIVIRALD 458

  Fly   302 LAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRM 366
            |....:|..|||.:|.|......|:..:.........:...|...::|.|||||||.:.:.:
  Rat   459 LVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDI--- 520

  Fly   367 FIFDKVEGNDSSFLEFEMTGSTYEPIGEVFLNGQRI------------------------KAADY 407
                                     :|.|.|.||.:                        .:..:
  Rat   521 -------------------------MGVVPLKGQMLLPLVPEPCHLPPGPLLRALVTCHALSQLH 560

  Fly   408 DTL----QEL----STICIMCNDSAIDYNEFKQAFEKVGEATETALIVL-----------AEKLN 453
            |||    .:|    ||..::...||            .|.|.||.::|:           .|...
  Rat   561 DTLVGDPMDLKMVESTGWVLEEGSA------------AGSAPETQVLVVMRPPPRGPQQQEESPE 613

  Fly   454 SFSVNK-----SGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLF 513
            ..||.:     |.|.|....:...|                                 .|.|:.:
  Rat   614 PVSVLRRFPFSSALQRMDVVVTWPG---------------------------------ATQPEAY 645

  Fly   514 VKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDL 578
            |||:||.|...|:..   |........|::...|          ..|.:|||....|..| .::.
  Rat   646 VKGSPELVASLCSPE---TVPRDFPQVLQSYTAA----------GYRVVALAGKPLPTAP-SLEA 696

  Fly   579 GDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFA 643
            .........|..|:.:|::.|.:..:.:....|...|..|||.:::||||..||..:.:..|:..
  Rat   697 AQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTVMVTGDNLQTAVTVAKACGMVG 761

  Fly   644 EDE-----DTTGKSYSGREFDDLSPTEQKAAV-----------------ARSR------------ 674
            ..|     ..|..........:..|||..||:                 ::||
  Rat   762 TQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKDPVQATDYPVEPESQSRHLALSGSTFAVL 826

  Fly   675 ----------------LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSG 723
                            :|:|:.|:.|:::|..||.:.....|.|||.||..|||.|::||::...
  Rat   827 QKHFPKLLPKVLVQATVFARMAPEQKTQLVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQA 891

  Fly   724 TAVAKSAAEMVLADDNFSSIVSAVEEGR-------------AIYNNMKQFIR----YLISSNIGE 771
            .|...|.....:|  :...:.:.:.|||             |:| ::.|||.    |.|::|:|:
  Rat   892 EASVVSPFTSSMA--SIECVPTVIREGRCSLDTSFSVFKYMALY-SLTQFISVLILYTINTNLGD 953

  Fly   772 V----VSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGW 832
            :    :.:|:|..:.:             |::...||..|        :..:||.......:.|.
  Rat   954 LQFLAIDLFITTTVAV-------------LMSRTGPALTL--------VRARPPGALLSVPVLGS 997

  Fly   833 LFFRY-MAIGFYVGAATVGAAAWWFV-------FSDEGP--------KLSYWQLTHHLSCLGGGD 881
            |..:. :..|..:|...:..|..|||       ..|..|        .||.:|.....:.:..|.
  Rat   998 LLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENTVIFSLSGFQYLILAAAVSKGA 1062

  Fly   882 EFKGVDCKIFSD-PHAMTMAL--SVLVTIEMLN-------AMNSLSENQSLITMPPWCNLWLIGS 936
            .|:.   .:::: |..:.:||  ||||.:.::.       .:.:::::.        ..|.|:|.
  Rat  1063 PFRQ---PLYTNVPFLVALALLGSVLVGLILVPGLLQGPLGLRNIADSS--------FKLLLLGL 1116

  Fly   937 MALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLDETLKFVARKIADGESP 997
            :|.:|...|::     .|.:.|..| :..:|:...:.|      .:..|.:.|::|:...|
  Rat  1117 VAFNFVGAFML-----ESVLDQCLP-ACLQWLRPKRAS------KKQFKQLQRELAERPWP 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	232/1156 (20%)
Atp13a2	XP_006239308.1	P-ATPase-V	39..1116	CDD:273738	222/1103 (20%)
		P5-ATPase	39..>110	CDD:289194
		E1-E2_ATPase	258..493	CDD:278548	64/295 (22%)
		Cation_ATPase	<621..658	CDD:289987	12/69 (17%)
		COG4087	<843..>892	CDD:226572	19/48 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910