Protein Alignment SERCA and atp13a1

DIOPT Version :9

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_001001403.2
• Gene: atp13a1 / 334466
• ZFINID: ZDB-GENE-040426-2804
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1148
• Identity: 245/1148 - (21%)
• Similarity: 414/1148 - (36%)
• Gaps: 365/1148 - (31%)

  Fly    28 QIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALF-------EE--HEE 83
            |::|.:|:||.|..         ::|:..|.:|..:   .|....||..:|       :|  :..
Zfish   189 QLRAAEKRYGTNRA---------EMVVPDFLELFKE---RATAPFFVFQVFCVGLWCLDEYWYYS 241

  Fly    84 TFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRAKEIVPG 148
            .||.|        :|:|.....|.|:....|.|..:.. :|.|.:|.|..|  .:.:.:.|:|||
Zfish   242 VFTLF--------MLVAFEASLVQQQMRNMSEIRRMGN-KPYMIQVYRNRK--WRPISSDELVPG 295

  Fly   149 DLVEVSVG-----DKIPADIRITHIYSTTLR----IDQSILTGESVSVIKHTDAIPDPRAV---- 200
            |:  ||||     :.:|.|:.:       ||    :|:::||||||..:|......||..:
Zfish   296 DI--VSVGRSPQDNLVPCDVLL-------LRGRCIVDEAMLTGESVPQMKEPIEDLDPNRILDLQ 351

  Fly   201 NQDKKNILFSGTNV--------AAGKARGV-------VIGTGLSTAIGK-IRTEMSETEEIKTPL 249
            ...:.:|:..||.|        |:...:.|       |:.||..|:.|| :||.:.   .:|...
Zfish   352 TDSRLHIISGGTKVVQHSPPLRASAGLKPVDNGCVAYVLRTGFYTSQGKLLRTILF---GVKRVT 413

  Fly   250 QQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGA-------IYYFKIAVALAVAAI 307
            ...|:.|...|..::..|..||:.              |::|.       ...|.....:..:.:
Zfish   414 ANNLETFIFILFLLVFAIAAAVYV--------------WVEGTKDPSRNKYKLFLECTLILTSVV 464

  Fly   308 PEGLP-----AVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMF 367
            |..||     ||.|:.:||     ||..........:...|...:.|.|||||||::.:.|..:
Zfish   465 PPELPIELSLAVNTSLIAL-----AKLYVFCTEPFRIPFAGKVEICCFDKTGTLTSDSLVVRGV- 523

  Fly   368 IFDKVEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQ 432
                     :...|    |....|:.|:.::..|:.|    |...|.|:    :|..:
Zfish   524 ---------AGLRE----GKQVMPVSEIPVDTHRVVA----TCHSLVTL----DDGQL------- 560

  Fly   433 AFEKVGEATETALIVLA-------EKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRD 490
                ||:..|.|::..|       ||:.:.|:...||               |..:.|....:..
Zfish   561 ----VGDPLEKAMLTAADWTLTKDEKVFARSIKTPGL---------------KIHQRFHFTSALK 606

  Fly   491 RKS-MSSYCTPLKASRLGTGPKLF---VKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQ 551
            |.| ::||      .|:|:....:   ||||||.:....:.......:|               .
Zfish   607 RMSVLASY------ERMGSTELCYISTVKGAPETLRNMFSECPASYDEV---------------H 650

  Fly   552 YGTGRDTLRCLALAVAD----SPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIV 612
            ....|:..|.|||...:    |..:..|:..      .|.|.:|.|.|.: ::..|.|....:::
Zfish   651 REMSREGARVLALGYKEMGHLSHQQVREVSR------EQLECDLRFAGFM-VVSCPLKSDSKAVI 708

  Fly   613 R-CRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDT---------------------------- 648
            | .:.|...|::|||||..||..:.|.:. |.:.|.|
Zfish   709 REIQEASHHVVMITGDNPLTACHVARELH-FIQKEHTLILQQSSSQAEWQWVSIDGSVSLPLPPS 772

  Fly   649 -------------TGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAM 700
                         ||:..:..:||   |....|.:...|:|:||.|:.|..::..|:.:..::.|
Zfish   773 SVSELIQRYDLCVTGEGLARLKFD---PQLLSALLPHVRVFARVSPKQKEFVITSLKGLGFVTLM 834

  Fly   701 TGDGVNDAPALKKAEIGIAM---------------------------------GSGTAVAKSAAE 732
            .|||.||..|||.|.||:|:                                 ..|...:::|.:
Zfish   835 CGDGTNDVGALKHAHIGVALLANAPERMPEKKKRNKEKEYSSGESRPGPPVPTSGGKLSSRAARQ 899

  Fly   733 MVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLP--EALIPVQLLWV 795
            .::|...        |:..|....:.|.:|.|....| :||.:. .|::..|  ..|..:|.: .
Zfish   900 RLMAQRE--------EQLAAQKERISQVLRELEEDQI-QVVKLG-DASIAAPFTSKLSSIQCI-C 953

  Fly   796 NLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSD 860
            :::..|...                       |::....|:.:|:...:.|.:..      |...
Zfish   954 HVIKQGRCT-----------------------LVTTLQMFKILALNALILAYSQS------VLYL 989

  Fly   861 EGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSENQSLITM 925
            ||.|.|.:|.|.....|.|        |.:|               |.....:.|||:.:.|
Zfish   990 EGVKFSDFQATLQGLLLAG--------CFLF---------------ISRSKPLKSLSKERPL--- 1028

  Fly   926 PPWCNLWLIGSMALSFTLHF---VILYVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLDETLKFV 987
            |...||:.:.::.|.|.:||   |.||....:.    :|..:|:::.:.|...| .|::.|:..:
Zfish  1029 PNIFNLYTVLTVLLQFAVHFCSLVYLYKGAQTR----SPPRSEQFVDLYKEFEP-SLINSTVYIM 1088

  Fly   988 ARKIADGESPI-YKMHGIV--------LMWAV------FFGLL 1015
            :..:......| ||.|..:        |:|::      ..|||
Zfish  1089 SMAMQMATFAINYKGHPFMESLTENRPLLWSIAISGLAIVGLL 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	236/1105 (21%)
atp13a1	NP_001001403.2	P-ATPase-V	84..1155	CDD:273738	245/1148 (21%)
		E1-E2_ATPase	277..485	CDD:278548	58/240 (24%)
		COG4087	<804..861	CDD:226572	20/56 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910