DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and Atp13a5

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	XP_038944228.1	Gene:	Atp13a5 / 303856	RGDID:	1306792	Length:	1237	Species:	Rattus norvegicus

Alignment Length:	1141	Identity:	236/1141 - (20%)
Similarity:	399/1141 - (34%)	Gaps:	335/1141 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEEHEETFTA 87
            |||.::.:..:...|||.:..|. :.||:|:::|   :|....:..|   |.|.|:...     .
  Rat   170 GLTSEEQEVRRLVCGPNAIEVEI-QPIWKLLVKQ---VLNPFYVFQA---FTLTLWLSQ-----G 222

  Fly    88 FVEPLVILLIL-IANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRAKEIVPGDLV 151
            ::|..|.::|| :.:.|:.|:..|.....:..|.|...::...:.....|:|::.::.:||||::
  Rat   223 YIEYSVAIIILTVISIVLSVYDLRQQSVKLHKLVEDHNKVQVTITVRDKGLQELESRLLVPGDIL 287

  Fly   152 EVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVN---------QD-KKN 206
            .:.....:|.|   ..:...:..:::.:|||||:.|.|    .|.|:..|         :| :|:
  Rat   288 ILPGKISLPCD---AVLIDGSCVVNEGMLTGESIPVTK----TPLPQTENTMPWKSHSLEDYRKH 345

  Fly   207 ILFSGTNV------AAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSKVIS 265
            :||.||.|      ..|..|.||:.||.:||.|    ::..:.....||..||  :.:....::.
  Rat   346 VLFCGTEVIQVKPSGQGPVRAVVLQTGYNTAKG----DLVRSILYPRPLNFKL--YNDAFKFMVF 404

  Fly   266 VICVAVWAINIGHFNDPAHGGSWIKGAIYYFKI--------AVALAVAAIPEGLPAVITTCLALG 322
            :.|:.|    :|.|        :..|...|.::        |:.|..|.:|..|||.:|......
  Rat   405 LACIGV----VGFF--------YALGVYLYHEVPPRETVTMALILLTATVPPVLPAALTIGNVYA 457

  Fly   323 TRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSV------------------------ 363
            .:|:.||.....|...:...|..:::|.|||||||.:.:.:
  Rat   458 QKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWGTVPTAGNCFQAVHSFASGEAVP 522

  Fly   364 ------------SRMFIFDKVEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTI 416
                        |.:.:...::|:......||.||...|       :|| :.:..|.|....:.|
  Rat   523 WGPLCAAMASCHSLILLDGTIQGDPLDLKMFEGTGWNME-------DGQ-VASCKYSTADSGTVI 579

  Fly   417 CIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKK 481
                               |.|.....:.:.....|..|..: |||.|.|......|::
  Rat   580 -------------------KPGPNASQSPVDSITILRQFPFS-SGLQRMSVIAQLAGDL------ 618

  Fly   482 EFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKIL 546
                                   ||    .:::|||||.|...|:     :..||.....:.:..
  Rat   619 -----------------------RL----HVYMKGAPEMVARFCS-----SETVPKNFPQELRNY 651

  Fly   547 ALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSI 611
            .:.|        .|.:||  |...:|.:::...:.....:.|..|.|:|::.|.:..:.|....:
  Rat   652 TVQG--------FRVIAL--AHKTLKMEKVSDVERLAREKVESELAFLGLLIMENRLKNETRPVL 706

  Fly   612 VRCRAAGIRVIVITGDNKATAEAICRR----------IGVFAED--------------------- 645
            .....|.||.:::||||..||..:.:.          |.|.|.:
  Rat   707 QELSEARIRTVMVTGDNLQTAITVAKNSEMIPVGSQVIIVEANEPGDLVPASVTWQLVGTQEPGS 771

  Fly   646 -----------------------EDT----------TGKSY----SGREFDDL-----SPTEQKA 668
                                   :||          .||.|    ||:.:..|     |...|
  Rat   772 EKKVSQGSQQCFRSPCRNHAFRFQDTYIDIGNSSVPCGKGYHFAMSGKSYQVLFHHFYSMLPQ-- 834

  Fly   669 AVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEM 733
            .:....:|:|:.|..||.:||..|.:|....|.|||.||..|||.|..||::....|...|....
  Rat   835 ILVNGTVFARMSPGQKSSLVEEFQKLNYYVGMCGDGANDCGALKMAHAGISLSEQEASVASPFTS 899

  Fly   734 VLADDNFSSIVSAVEEGRAI---------YNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIP 789
            .:|  |...:...:.||||.         |..|...|:::.:|.:...:.:|......|.:..|.
  Rat   900 KVA--NIECVPHLIREGRAALVSSFGVFKYLTMYGIIQFIGTSLLYWQLQLFGNYQYLLQDVAIT 962

  Fly   790 VQLLWVNLVTDGLPATALGFNPPD--------------------------LDIMEKP----PRKA 824
            :.:.....:....|..| .:.|..                          |.:.::|    ..|.
  Rat   963 LMVSLTMSINHAYPKLA-PYRPAGQLLSPQLLLSVFMNSCFTCIVLVCTFLSVKQQPWYCEVYKY 1026

  Fly   825 DE-------------GLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSC 876
            .|             ||...|           .|.||:..|:   |.|.||..|  |.:. ..:|
  Rat  1027 SECFLVNQSNFSTNMGLERNW-----------TGNATLVPAS---VLSFEGTTL--WPIV-TFNC 1074

  Fly   877 LGGGDEF-KGVDCKIFSDPHAMTMALSVLVTIEM-LNAMNSLSENQSL---ITMPPWCNLWLIGS 936
            :.....| ||   |.|..|.......|:|:|..: |......|:.|.:   :...|....|.|..
  Rat  1075 ISAAFIFSKG---KPFRKPIYTNYLFSLLLTSAVGLTVFILFSDFQDIYRRMEFIPTTTSWRISI 1136

  Fly   937 MALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMK 972
            :..:|....|..:|:  ..:.|    :.|.|:.:.|
  Rat  1137 LVAAFVQFCVAFFVE--DAILQ----NRELWLFIKK 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	236/1141 (21%)
Atp13a5	XP_038944228.1	P5-ATPase	23..142	CDD:403569
Atp13a5	XP_038944228.1	P-type_ATPase_cation	174..1020	CDD:319842	195/963 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910