DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and Atp2a2

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_001104293.1	Gene:	Atp2a2 / 29693	RGDID:	2174	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	989	Identity:	718/989 - (72%)
Similarity:	838/989 - (84%)	Gaps:	1/989 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65
            ||:.|:||||:.|..||.:...||:|:|:|..::::|.||||.||||::.:||:|||:||||:||
  Rat     1 MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL 65

  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130
            ||||.||||||.|||.|||.||||||.||||||:|||:||||||||||:|||||||||||||||.
  Rat    66 LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVY 130

  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195
            |||:..:|:::||:|||||:||::||||:|||||:|.|.|||||:|||||||||||||||||.:|
  Rat   131 RQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVP 195

  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260
            |||||||||||:||||||:|||||.|||:.||::|.|||||.||..||:.:||||||||||||||
  Rat   196 DPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQL 260

  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |||||:||:|||.|||||||||.||||||:|||||||||||||||||||||||||||||||||||
  Rat   261 SKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390
            ||||||||||||||||||||||||||||||||||||||.||||.|||||:..|..||.:|||||.
  Rat   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFTITGSTYA 390

  Fly   391 PIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455
            |||||..:.:.:|...||.|.||:|||.:|||||:||||.|..:|||||||||||..|.||:|.|
  Rat   391 PIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVF 455

  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEG 520
            .....||.:...|.||...|:...||||||||||||||||.||||.|.||.... |:||||||||
  Rat   456 DTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMS-KMFVKGAPEG 519

  Fly   521 VLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFY 585
            |::||||.|||:||||:|..:|.||:::..::|:|.|||||||||..|:|::.:||.|.||..|.
  Rat   520 VIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFI 584

  Fly   586 QYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTG 650
            :||.||||||.||||||||.||..|:..||.||||||:||||||.||.|||||||:|.:|||.|.
  Rat   585 KYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTS 649

  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715
            |:::|||||:|||:.|:.|...:|.|:||||.|||||||||||.:||:|||||||||||||||:|
  Rat   650 KAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSE 714

  Fly   716 IGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAA 780
            |||||||||||||:|:||||||||||:||:|||||||||||||||||||||||:||||.||||||
  Rat   715 IGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA 779

  Fly   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVG 845
            ||.||||||||||||||||||||||||||||||||||.||||...|.||||||||||:|||.|||
  Rat   780 LGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVG 844

  Fly   846 AATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEML 910
            |||||||||||:.:|.||::|::||:|.|.|.....:|:||||.||..|:.|||||||||||||.
  Rat   845 AATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMC 909

  Fly   911 NAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSI 975
            ||:|||||||||:.||||.|:||:||:.||.:|||:||||:.|..:||:|||:..:|:.|:|.|:
  Rat   910 NALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISL 974

  Fly   976 PVVLLDETLKFVAR 989
            ||:|:|||||||||
  Rat   975 PVILMDETLKFVAR 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	714/983 (73%)
Atp2a2	NP_001104293.1	Cation_ATPase_N	4..72	CDD:279080	37/67 (55%)
		ATPase-IIA1_Ca	53..988	CDD:273452	691/935 (74%)
		E1-E2_ATPase	93..340	CDD:278548	205/246 (83%)
		Cation_ATPase	419..527	CDD:289987	68/108 (63%)
		Interaction with HAX1. /evidence=ECO:0000250	575..594		11/18 (61%)
		HAD	<605..711	CDD:289480	73/105 (70%)
		Cation_ATPase_C	783..986	CDD:279079	143/202 (71%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	787..807		19/19 (100%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000250\|UniProtKB:O55143	788..1043		142/201 (71%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	931..942		6/10 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I977
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1443	1.000	Inparanoid score	I106
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm45935
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	O	PTHR42861
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X745
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840