Protein Alignment SERCA and ATP2C1

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_001365440.1
• Gene: ATP2C1 / 27032
• HGNCID: 13211
• Length: 983
• Species: Homo sapiens
• Alignment Length: 1003
• Identity: 342/1003 - (34%)
• Similarity: 517/1003 - (51%)
• Gaps: 155/1003 - (15%)

  Fly     9 VEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISF 73
            |.:..:....|.:.||...::...:..:|.||....|.:.:|:..:.||.:.|:.:||.:|:||.
Human    65 VSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISV 129

  Fly    74 VLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQ 138
            ::..|::       .|...|.:||::..|.|   ||..:|.::|.|.:..|.....||:.|  ::
Human   130 LMHQFDD-------AVSITVAILIVVTVAFV---QEYRSEKSLEELSKLVPPECHCVREGK--LE 182

  Fly   139 KVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQD 203
            ...|:::||||.|.:||||::|||:|:  ..:..|.||:|.||||:....|.|  .|.|.|.|.|
Human   183 HTLARDLVPGDTVCLSVGDRVPADLRL--FEAVDLSIDESSLTGETTPCSKVT--APQPAATNGD 243

  Fly   204 ---KKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS---- 261
               :.||.|.||.|..|||:|||||||.::..|::...|...|..|||||:.:|..|:|||
Human   244 LASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSF 308

  Fly   262 KVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM 326
            .:|.:|.:..|.:.              |..:..|.|:|:|||||||||||.|:|..||||..||
Human   309 GIIGIIMLVGWLLG--------------KDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRM 359

  Fly   327 AKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEP 391
            .||.|||:.||.||||||.:|||||||||||.|:|:|:.:|..|.        |..|:||..|..
Human   360 VKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDG--------LHAEVTGVGYNQ 416

  Fly   392 IGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFS 456
            .|||.::|..:.......:..:.....:|||:.|..|..      :|:.||.|||.||.|:
Human   417 FGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTL------MGKPTEGALIALAMKM---- 471

  Fly   457 VNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCT-PLKASRLGTGPKL-FVKGAPE 519
                |||          .::..:.::....||.::|.|:..|. ..:..|    |:: |:|||.|
Human   472 ----GLD----------GLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDR----PEICFMKGAYE 518

  Fly   520 GVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDT------------LRCLALAVADSPMK 572
            .|::.||           |...|.:.|.||.|.   ||.            ||.|||  |..|
Human   519 QVIKYCT-----------TYQSKGQTLTLTQQQ---RDVYQQEKARMGSAGLRVLAL--ASGP-- 565

  Fly   573 PDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICR 637
                :||          .|||:|:||::||||..|.:::....|:|:.:.:||||::.||.||..
Human   566 ----ELG----------QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIAS 616

  Fly   638 RIGVFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTG 702
            |:|::::    |.:|.||.|.|.:...:....|.:..:|.|..|:||.||::.||....:.||||
Human   617 RLGLYSK----TSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTG 677

  Fly   703 DGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLIS 766
            ||||||.|||.|:||:||| :||.|.|.||:|:|.||:|.:|:||:|||:.||||:|.|:|:.:|
Human   678 DGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLS 742

  Fly   767 SNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISG 831
            ::|..:..|.|...:..|..|..:|:||:|::.||.||.:||..|.|.|::.||||...:.:::.
Human   743 TSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTK 807

  Fly   832 WLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHA 896
            .|..:.:.....:...|:      |||         |:            |.:  |..|  .|..
Human   808 NLILKILVSSIIIVCGTL------FVF---------WR------------ELR--DNVI--TPRD 841

  Fly   897 MTMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTP 961
            .||..:..|..:|.||::|.|:.:|:..:....|.....::..|.....:::|...|..|||...
Human   842 TTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTES 906

  Fly   962 LSAEEWITVMKFSIPVVLLDETLKFVAR 989
            ||..:.:.::..:..|.::.|.:|.|.|
Human   907 LSILDLLFLLGLTSSVCIVAEIIKKVER 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	341/1001 (34%)
ATP2C1	NP_001365440.1	ATPase-IIA2_Ca	57..937	CDD:130585	342/1003 (34%)