DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and atp2a1

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_001007030.1	Gene:	atp2a1 / 260440	ZFINID:	ZDB-GENE-020905-1	Length:	994	Species:	Danio rerio

Alignment Length:	989	Identity:	715/989 - (72%)
Similarity:	837/989 - (84%)	Gaps:	0/989 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65
            ||:.|:|...:.|.:||.....|||.:|:|.||.|||.||||.|||||||:||:|||:||||:||
Zfish     1 MENAHTKETPECLAYFGVSESTGLTPEQVKKNQAKYGFNELPAEEGKSIWELVVEQFEDLLVRIL 65

  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130
            ||||.||||||.|||.|||.||||||.|||||||||||||||||||||||||||||||||||||.
Zfish    66 LLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVY 130

  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195
            |.|:..:|:::|:||||||:||||||||:|||||||.|.|||||:||||||||||||||||:::|
Zfish   131 RSDRKSVQRIKAREIVPGDIVEVSVGDKVPADIRITAIRSTTLRVDQSILTGESVSVIKHTESVP 195

  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260
            |||||||||||:||||||:|||||.|||:.||:||.|||||.:|:.||:.|||||||||||||||
Zfish   196 DPRAVNQDKKNMLFSGTNIAAGKAIGVVVATGVSTEIGKIRDQMAATEQEKTPLQQKLDEFGEQL 260

  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |||||:||||||.|||||||||.||||||:||:||||||||||||||||||||||||||||||||
Zfish   261 SKVISLICVAVWLINIGHFNDPVHGGSWIRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390
            ||||||||||||||||||||||||||||||||||||.|::||:.:||||...:..:::::||.|.
Zfish   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMCVTKMFVIEKVEGESVTLDQYDISGSKYT 390

  Fly   391 PIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455
            |.|||..||..:|...:|.|.||:|||.:||||::||||.|..:|||||||||||..|.||:|.|
Zfish   391 PEGEVTKNGLPVKCGQFDGLVELATICALCNDSSLDYNESKGIYEKVGEATETALCCLVEKMNVF 455

  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEG 520
            :.:..||.:...|..|...|:...||:|||||||||||||.||:|.|||:...|.|:||||||||
Zfish   456 NTDVRGLSKVERANTCCAVIKQLMKKDFTLEFSRDRKSMSVYCSPAKASKAPVGNKMFVKGAPEG 520

  Fly   521 VLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFY 585
            |::||.:.|||||:||||..:|.||:|:..::|||||||||||||..|:|::|:||:|.|||||.
Zfish   521 VIDRCAYVRVGTTRVPLTGPVKDKIMAVIKEWGTGRDTLRCLALATRDNPLRPEEMNLEDSTKFA 585

  Fly   586 QYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTG 650
            :||.:|||||.|||||||||||..||..|||||||||:||||||.||.|||||||:|::|||.||
Zfish   586 EYETDLTFVGCVGMLDPPRKEVVGSIELCRAAGIRVIMITGDNKGTAVAICRRIGIFSDDEDVTG 650

  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715
            ::::|||||||...:|:.||.::..::||||.||||||||||..:||:|||||||||||||||||
Zfish   651 RAFTGREFDDLPLPQQREAVRKACCYARVEPSHKSKIVEFLQGFDEITAMTGDGVNDAPALKKAE 715

  Fly   716 IGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAA 780
            |||||||||||||||:|||||||||||||:|||||||||||||||||||||||:||||.||||||
Zfish   716 IGIAMGSGTAVAKSASEMVLADDNFSSIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA 780

  Fly   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVG 845
            |||||||||||||||||||||||||||||||||||||.|.||...|.||||||||||:|||.|||
Zfish   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMGKAPRSPKEPLISGWLFFRYLAIGGYVG 845

  Fly   846 AATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEML 910
            ||||.||.|||::.||||.:|::||:|.:.|....::|.|::|::|.....|||||||||||||.
Zfish   846 AATVAAAGWWFLYCDEGPMVSFYQLSHFMQCTADNEDFAGIECEVFEAAPPMTMALSVLVTIEMC 910

  Fly   911 NAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSI 975
            ||:|||||||||:.||||.||||.|:|.||.:|||:|:|||.|..:|::|.|:.::||.|:|.|.
Zfish   911 NALNSLSENQSLLRMPPWSNLWLAGAMTLSMSLHFMIIYVDPLPMIFKLTHLNFDQWIVVLKLSF 975

  Fly   976 PVVLLDETLKFVAR 989
            ||:|:||.||||||
Zfish   976 PVILIDEALKFVAR 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	711/983 (72%)
atp2a1	NP_001007030.1	Cation_ATPase_N	4..72	CDD:279080	41/67 (61%)
		ATPase-IIA1_Ca	53..989	CDD:273452	684/935 (73%)
		E1-E2_ATPase	93..340	CDD:278548	210/246 (85%)
		Cation_ATPase	419..528	CDD:289987	64/108 (59%)
		HAD	<604..712	CDD:289480	74/107 (69%)
		Cation_ATPase_C	784..987	CDD:279079	135/202 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	353	1.000	Domainoid score	I959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7635
Inparanoid	1	1.050	1428	1.000	Inparanoid score	I114
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm24260
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	LDO	PTHR42861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3239
SonicParanoid	1	1.000	-	-		X745
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010