Protein Alignment SERCA and pmc1

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_593890.1
• Gene: pmc1 / 2543477
• PomBaseID: SPAPB2B4.04C
• Length: 1292
• Species: Schizosaccharomyces pombe
• Alignment Length: 1110
• Identity: 308/1110 - (27%)
• Similarity: 494/1110 - (44%)
• Gaps: 249/1110 - (22%)

  Fly    18 TDPERGLTLDQIKANQ--------------KKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLA 68
            ::|:..:.||:|::..              |.||.|.||..:.|.:.:|:||.|.|.::.:|.:|
pombe   180 SNPKLVVHLDRIRSQDNNPEAKVSHDSDRVKYYGKNVLPEHDSKGLIRLMLEAFKDKVLILLSIA 244

  Fly    69 AIISFVLALFEE------------HEETFTAFVEPLVIL-LILIANAVVGV--WQER------NA 112
            |::|..|.|::.            ..|....:||.:.|: .|:|...|.||  ||:.      ||
pombe   245 AVVSLALGLYQTFGQPPTLDPITGKPEPRVEWVEGVAIMAAIVIVVTVGGVNDWQKELQFKKLNA 309

  Fly   113 ESA---IEALKEYEPEMGKVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLR 174
            :.:   ::.|::             ..:......::|.||::.|..||.:|.|..:  |.|..|.
pombe   310 KVSNFDVQVLRD-------------GAVHSTSVFDLVVGDVLFVEAGDVVPVDGVL--IESNNLV 359

  Fly   175 IDQSILTGESVSVIKHTDAIPDPRAVNQD---KKN---ILFSGTNVAAGKARGVVIGTGLSTAIG 233
            :|:|.:|||:.: ||..||.......:.|   :||   .|.|||.:..|..:.:|...|:::..|
pombe   360 LDESAMTGETDN-IKKVDANTAIERTSPDVEYRKNADPYLISGTTILEGNGKLLVTAVGVNSFNG 423

  Fly   234 KIRTEMS-ETEEIKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHF------NDPAHGGSWIKG 291
              ||.|: .||...||||.:|....:.::|:.......::.:.:..|      ||   ..|..||
pombe   424 --RTTMAMRTEGQATPLQLRLSRVADAIAKLGGAASALLFIVLLIEFLVRLKSND---SSSKNKG 483

  Fly   292 A--IYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTG 354
            .  :....::|.|.|.|:|||||..:|..||..|.||.|.|.:||.|.:.||:|..:.|||||||
pombe   484 QEFLQILIVSVTLLVVAVPEGLPLAVTLALAFATNRMQKDNNLVRHLQACETMGTATNICSDKTG 548

  Fly   355 TLTTNQMSV------SRMFIFDK--------VEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIKAA 405
            |||.|:|:|      :.:..||.        .:|:|||  :||..|::....       :|:.
pombe   549 TLTQNRMTVVAGGFGTDVLFFDHNDETPTNVDQGSDSS--KFEDAGASAFAF-------KRLS-- 602

  Fly   406 DYDTLQELSTICIMCNDSAIDYNEFKQAFEK-------VGEATETALIVLAEKLNSFSVNKSGLD 463
              ..|::|:...|..|.:.      :|.||.       :|..|||||:       ..||.:.||
pombe   603 --PELRDLTLYSIAVNSTC------RQLFEDNSDTPRFIGSKTETALL-------DMSVKELGL- 651

  Fly   464 RRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLF---------VKGAPE 519
              :...:.|..::.   |:| ..||.|||:..:               :|         |||.||
pombe   652 --TNVDSMRSSVDI---KQF-FSFSSDRKASGA---------------IFEYKDKYYFVVKGMPE 695

  Fly   520 GVLERCT--------------HARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALA--VAD 568
            .||::.|              |:.....|..:|              |..:.:||.|.|.  |.|
pombe   696 RVLQQSTSVITNGSLDEVEDMHSHADYFKEMIT--------------GYAKRSLRTLGLCYRVFD 746

  Fly   569 S-PMKPDEMDLGDSTKFYQYE---VNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNK 629
            | |.|....:..||:...::|   .::||:|..|::||.|.:|..::..|:.||:.|.::||||.
pombe   747 SWPPKDIPTNDEDSSNPLKWEDAFTDMTFLGFFGIMDPIRPDVPLAVKVCQGAGVTVRMVTGDNI 811

  Fly   630 ATAEAICRRIGVFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSM 694
            .||:||..:.|::.||    |.|..|.||..||..::...:.:..:.:|..|..|..::|.||.:
pombe   812 VTAKAIASQCGIYTED----GISMEGPEFRSLSDEKRLEILPKLDVLARSSPLDKQLLIEGLQKL 872

  Fly   695 NEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMK 758
            ..:.|:||||.|||||||||.:|.:|| |||.|||.|::::|.||||||||.|:..||.:.:.:|
pombe   873 GNVVAVTGDGTNDAPALKKANVGFSMGKSGTEVAKEASDIILMDDNFSSIVKAIAWGRTVNDAVK 937

  Fly   759 QFIRYLISSNIGEVVSIFLT-----AALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIME 818
            :|:::.|:.||   .::|||     |:......|..||||||||:.|.|.|.||..:||..::::
pombe   938 KFLQFQITVNI---TAVFLTIISAVASTDQSSVLTAVQLLWVNLIMDTLAALALATDPPTPEVLK 999

  Fly   819 KPPRKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEF 883
            :.|.|.                    ||:......|..:......:|:...:.|          |
pombe  1000 RKPEKP--------------------GASLFTFDMWKMIICQSMYQLAVTLVLH----------F 1034

  Fly   884 KGVDCKIFSDP----HAMTMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLW-LIGSMALSFTL 943
            .|  ..||..|    ...|:..:..|.:::.|.:|:...:..|       |:: .|....|...:
pombe  1035 AG--NSIFHYPSNTADMNTIVFNTFVWLQLFNEINNRRLDNKL-------NIFERINHNFLFIAI 1090

  Fly   944 HFVILYVDVL-----STVFQVTPLSAEEWITVMKFSIPVVLLDETLKFVARKIADGESPIYKMHG 1003
            ..::..:.|:     ...|.|..:..:.|...:.|.:..:.|...::.|.........|: |...
pombe  1091 FVIVAGIQVIIVFFGGAAFSVKRIDGKGWAISIVFGVISIPLGALIRCVPNNFLRKVLPV-KTID 1154

  Fly  1004 IVLMW 1008
            .|..|
pombe  1155 TVFSW 1159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	304/1089 (28%)
pmc1	NP_593890.1	P-type_ATPase_Ca_PMCA-like	206..1014	CDD:319776	277/917 (30%)
		Cation_ATPase_C	966..1137	CDD:376368	42/209 (20%)