DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and cta3

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_595246.1	Gene:	cta3 / 2541204	PomBaseID:	SPBC839.06	Length:	1037	Species:	Schizosaccharomyces pombe

Alignment Length:	1086	Identity:	323/1086 - (29%)
Similarity:	508/1086 - (46%)	Gaps:	200/1086 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAII 71
            |.||..   |.|....|||.::.:....:||.|.|..:.|.|.|:::|.|..:.:..:|:|||.:
pombe    16 KDVESE---FLTSIPNGLTHEEAQNRLSEYGENRLEADSGVSAWKVLLRQVLNAMCVVLILAAAL 77

  Fly    72 SFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSG 136
            ||          ..|.::|..||..|::.|..||..||..||..:::|:.....|..|.|..|:
pombe    78 SF----------GTTDWIEGGVISAIIVLNITVGFIQEYKAEKTMDSLRTLASPMAHVTRSSKT- 131

  Fly   137 IQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVN 201
             ..:.:..:||||:|.:..||.:|||:|:  :.:.....|:::|||||:.|||      |..|..
pombe   132 -DAIDSHLLVPGDVVVLKTGDVVPADLRL--VETVNFETDEALLTGESLPVIK------DAHATF 187

  Fly   202 Q--------DKKNILFSGTNVAAGKARGVVIGTGLSTAIGKI------------RTEMSETE--- 243
            |        |:.|:.:|.:.|..|:|:|:...||:.|.||.|            |.|..|..
pombe   188 QMNEDVPIGDRINLAYSSSIVTKGRAKGICYATGMQTQIGAIAAGLRQKGKLFQRPEKDEPNYRR 252

  Fly   244 --------------------EIKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSW 288
                                .:.||||:||......|..:..::.:.|.|.:..|..:..
pombe   253 KLNKYYLKVTSYYVQRVLGLNVGTPLQRKLTVLAYILFCIAIILAIIVMAAHSFHVTNEV----- 312

  Fly   289 IKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKT 353
               :||    |::|.::.|||.|.||::..:|:|.:.|:|:..|||.|.::|.||..:.||||||
pombe   313 ---SIY----AISLGISIIPESLIAVLSITMAMGQKNMSKRRVIVRKLEALEALGGVTDICSDKT 370

  Fly   354 GTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTL----QELS 414
            ||:|..:|...|::|      ....:|..:.:.:....||.|    ..::||..|.|    ||:.
pombe   371 GTITQGKMITRRVWI------PSYGYLSVDTSDANNPTIGTV----SGLEAAMQDVLKEKKQEMK 425

  Fly   415 TI----------------CIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFSVNKSGLD 463
            .|                |.:||.|.::..|..:...| ||.||.||.|.:::   |:..|..|.
pombe   426 NIDPSNQPSDQFIPLLKTCALCNLSTVNQTETGEWVVK-GEPTEIALHVFSKR---FNYGKEDLL 486

  Fly   464 RRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERCTHA 528
            :.:..:           :|:  .|..:.|.|:......:...     .::.|||.|.:||||:.:
pombe   487 KTNTFV-----------REY--PFDSEIKRMAVIYEDQQGQY-----TVYAKGAVERILERCSTS 533

  Fly   529 RVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFYQYEV---N 590
            ...|.:.|....:.|::..|..      :.||.||||.       ..:|..|:.:....:|   :
pombe   534 NGSTLEEPDRELIIAQMETLAA------EGLRVLALAT-------KVIDKADNWETLPRDVAESS 585

  Fly   591 LTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGV---FAEDED--TTG 650
            |.||.:||:.||||.|...::..|..|||||.::|||:..||:||.|.:|:   |..|.|  .:.
pombe   586 LEFVSLVGIYDPPRTESKGAVELCHRAGIRVHMLTGDHPETAKAIAREVGIIPPFISDRDPNMSW 650

  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715
            ...:|.:||.||..|..:..|...:.:|..||.|.|::|.|.......|||||||||:|:||:|.
pombe   651 MVMTGSQFDALSDEEVDSLKALCLVIARCAPQTKVKMIEALHRRKAFVAMTGDGVNDSPSLKQAN 715

  Fly   716 IGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTA 779
            :||||| :|:.|||.|:::||.||||||||:|:||||.:::|:.:|:.:|:.||:|||  |.|..
pombe   716 VGIAMGQNGSDVAKDASDIVLTDDNFSSIVNAIEEGRRMFDNIMRFVLHLLVSNVGEV--ILLVV 778

  Fly   780 ALGLPE-------ALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRY 837
            .|...:       .:.||::||.|::|...|:..||......|:||:.|.....|:....|....
pombe   779 GLAFRDEVHLSVFPMSPVEILWCNMITSSFPSMGLGMELAQPDVMERLPHDNKVGIFQKSLIVDM 843

  Fly   838 MAIGFYVGAATVGAAAWWFVFSDEGP-KLSYWQLTH-HLSCLGGGDEFKGVDCKIFSDPHAMTMA 900
            |..||::|  .|....|..:....|. .|||....| |..|   .|.||.... :|:   .:|..
pombe   844 MVYGFFLG--VVSLMTWVVIMYGFGTGNLSYDCNAHYHAGC---NDVFKARSA-VFA---VVTFC 899

  Fly   901 LSVLVTIEMLNAMNSLSENQSLITMPPWC-------------NLWLIGSMALSFTLHFVILYVDV 952
            : :::.:|:.|..|||.....:    ||.             |.:|..::||:....|..:|:.|
pombe   900 I-LIMAVEVKNFDNSLFNLHGI----PWGEWNFRYFLHTLVENKFLAWAIALAAVSVFPTIYIPV 959

  Fly   953 LS-TVFQVTPLSAEEW----ITVMKFSIPVVLLDETLKFVARKIAD 993
            :: .||:.|.: ..||    :.||.:...|    |..|.:.|.:.:
pombe   960 INRDVFKHTYI-GWEWGVVAVAVMFYFFYV----EIWKSIRRSLTN 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	322/1080 (30%)
cta3	NP_595246.1	ATPase-IID_K-Na	5..1003	CDD:130586	323/1086 (30%)
		Cation_ATPase_N	14..78	CDD:279080	21/64 (33%)
		E1-E2_ATPase	89..357	CDD:278548	82/289 (28%)
		Cation_ATPase	446..532	CDD:289987	27/107 (25%)
		COG4087	606..738	CDD:226572	57/131 (44%)
		Cation_ATPase_C	792..994	CDD:279079	57/220 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	48	1.000	Domainoid score	I3472
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820