DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and Atp2a3

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	XP_038941199.1	Gene:	Atp2a3 / 25391	RGDID:	2175	Length:	1069	Species:	Rattus norvegicus

Alignment Length:	995	Identity:	680/995 - (68%)
Similarity:	802/995 - (80%)	Gaps:	0/995 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65
            ||:.|..:....|..|....|.||||:|:...:::|||||||||||||:|:||:|||:||||:||
  Rat     1 MEEAHLLSAADVLRRFSVTAEGGLTLEQVTDARERYGPNELPTEEGKSLWELVVEQFEDLLVRIL 65

  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130
            ||||::|||||.|||.|||.|||||||||:|||:|||:||||||||||||||||||||||||||:
  Rat    66 LLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVI 130

  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195
            |.|:.|:|::||::|||||:|||:||||:|||:|:..|.|||||:||||||||||||.|||||||
  Rat   131 RSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTDAIP 195

  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260
            |||||||||||:||||||:|:|||.||.:.|||.|.:||||::|:..|..:||||:||||||.||
  Rat   196 DPRAVNQDKKNMLFSGTNIASGKALGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQL 260

  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |..|||||||||.||||||.||||||||::||:||||||||||||||||||||||||||||||||
  Rat   261 SHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390
            ||:|||||||||||||||||||||||||||||||||||.|||:..:.|.......||.::|:||.
  Rat   326 MARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAEAGACRLHEFTISGTTYT 390

  Fly   391 PIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455
            |.|||....|.::...:|.|.||:|||.:|||||:||||.|..:|||||||||||..|.||:|.|
  Rat   391 PEGEVRQGEQLVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVF 455

  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEG 520
            ..:..||.|...|.||...|:...:|||||||||||||||.||||.:|.....|.|:|||||||.
  Rat   456 DTDLKGLSRVERAGACNSVIKQLMRKEFTLEFSRDRKSMSVYCTPTRADPKAQGSKMFVKGAPES 520

  Fly   521 VLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFY 585
            |:|||:..|||:..|||::..:..|||....:|:|.|||||||||..|:|.:.::|.|.|.::|.
  Rat   521 VIERCSSVRVGSRTVPLSATSREHILAKIRDWGSGSDTLRCLALATRDTPPRKEDMQLDDCSQFV 585

  Fly   586 QYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTG 650
            |||..|||||.||||||||.||...|.||..|||||::||||||.||.|||||:|:|.:.||..|
  Rat   586 QYETGLTFVGCVGMLDPPRPEVAACITRCSRAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVLG 650

  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715
            |:|:|||||||||.:|:.|...:|.|:||||.|||:|||.|||.|||:|||||||||||||||||
  Rat   651 KAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAE 715

  Fly   716 IGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAA 780
            ||||||||||||||||||||:||||:|||:|||||||||||||||||||||||:||||.|||||.
  Rat   716 IGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAI 780

  Fly   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVG 845
            |||||||||||||||||||||||||||||||||||||||.||...|.||||||||||:|||.|||
  Rat   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRNPREALISGWLFFRYLAIGVYVG 845

  Fly   846 AATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEML 910
            .|||.||.|||::..|||::::.||.:.|.|......|.|:||::|......||||||||||||.
  Rat   846 LATVAAATWWFLYDAEGPQVTFHQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMC 910

  Fly   911 NAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSI 975
            ||:||:||||||:.||||.|.||:|::.:|..|||:||.|..|..:|||||||..:|..|::.|:
  Rat   911 NALNSVSENQSLLRMPPWLNPWLLGAVVMSMALHFLILLVPPLPLIFQVTPLSGRQWGVVLQMSL 975

  Fly   976 PVVLLDETLKFVARKIADGE 995
            ||:||||.||:::|...||:
  Rat   976 PVILLDEALKYLSRHHVDGK 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	675/983 (69%)
Atp2a3	XP_038941199.1	P-type_ATPase_SERCA	5..989	CDD:319778	675/983 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340972
Domainoid	1	1.000	314	1.000	Domainoid score	I1250
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1443	1.000	Inparanoid score	I106
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm45935
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	O	PTHR42861
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X745
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910