Protein Alignment SERCA and atp1a1a.5

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_835200.1
• Gene: atp1a1a.5 / 245703
• ZFINID: ZDB-GENE-020501-1
• Length: 1023
• Species: Danio rerio
• Alignment Length: 1069
• Identity: 319/1069 - (29%)
• Similarity: 494/1069 - (46%)
• Gaps: 173/1069 - (16%)

  Fly     3 DGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLL 67
            |.|..|:|:....:|||..:||.:.:......:.|||.|........|.....|.......:|.:
Zfish    43 DDHKLTMEELSRKYGTDLTKGLPVSRAMEVLMRDGPNALTPPVITPEWVRFCRQLFGGFQTLLWI 107

  Fly    68 AAIISFVLALFEEHEETFTAFVEP--------LVILLILIANAVVGVWQERNAESAIEALKEYEP 124
            .|.:.:.....:...|      ||        :|:..::..|......||..:...:::.|...|
Zfish   108 GAFLCYFAFSIQAATE------EPVNDNLYLGIVLTFVVTVNGCFSYSQEAKSCRIMDSFKNLVP 166

  Fly   125 EMGKVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIK 189
            :...|||..:..|  :.|:|:|.||||||..||||||||||  :.|...::|.|.|||||...|:
Zfish   167 QKALVVRDGEKKI--IDAEEVVVGDLVEVKGGDKIPADIRI--VSSHGCKVDNSSLTGESEPQIR 227

  Fly   190 HTDAIPDPRAVNQ-DKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKL 253
                .||..:.|. :.:||.|..||...|.|||:|:.||..|.:|:|.:..|..|..:|||.:::
Zfish   228 ----TPDMSSENPLETRNIAFFSTNCIDGAARGIVVNTGDRTVMGRIASLASNLEGGQTPLGREI 288

  Fly   254 DEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTC 318
            :.|...::.|...:......|::      ..|.:|::|.|:    .:.|.||.:|||||..:|..
Zfish   289 EHFIHIITGVAVFLGTTFLIISV------MLGFTWLEGIIF----LIGLIVANVPEGLPCTVTVA 343

  Fly   319 LALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFE 383
            |.|..:.|||||.:|::|.:|||||.||.||||||||||.|:|:|:.|:..:::...|::   ..
Zfish   344 LTLTAKHMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHIADTT---EN 405

  Fly   384 MTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAF---EKVGEATETAL 445
            .||::::          |..|    |...|:.:..:||.:....|:.....   |..|:|:|:||
Zfish   406 QTGASFD----------RSSA----TWSALARVAGLCNRAVFQSNQSHLPVLRRETAGDASESAL 456

  Fly   446 IVLAEKLNSFSVNKSGLDRRSAAIACRGEI---ETKWKKEFTLEFSRDRKSMSSYCTPLKASRLG 507
            :...|                   .|.|.:   ...:.|...:.|:    |:|.|...:..:...
Zfish   457 LKCIE-------------------LCCGSVTGMRENYPKVAEIPFN----SISKYQLSIHENPNS 498

  Fly   508 TGPK--LFVKGAPEGVLERCTHARVGTTKVPLTSALKAKIL-ALTGQYGTGRDTLRCLALAVADS 569
            :.||  |.:|||||.:|:||:...:...:.||...:|.... |.....|.|...|......:.|
Zfish   499 SEPKHLLVMKGAPERILDRCSTILIEGKEHPLDDEMKEDFQNAYVQLGGLGERVLGFCHFCLPD- 562

  Fly   570 PMKPDEMDLG---DSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKAT 631
                |:...|   |:.:......||.|||::.|:||||..|.|::.:||:|||:||::|||:..|
Zfish   563 ----DQFPEGFAFDTEEMNFPTENLCFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPIT 623

  Fly   632 AEAICRRIGVFAEDEDTTGKSYSGR---EFDDLSPTEQKAAVARSR------------------- 674
            |:||.:.:|:.:|..:|. ...:.|   ..|:::|.:.||.|....
Zfish   624 AKAIAKGVGIISEGNETV-DDIAARLKIHIDEVNPRDAKACVIHGGELKNMTDEQLDDVLQHHTE 687

  Fly   675 -LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLAD 737
             :|:|..||.|..|||..|....|.|:|||||||:||||||:||:||| :|:.|:|.||:|:|.|
Zfish   688 IVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLD 752

  Fly   738 DNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGL 802
            |||:|||:.|||||.|::|:|:.|.|.:|:.|.|:....:....|:|..|..|.:|.::|.||.:
Zfish   753 DNFASIVTGVEEGRLIFDNLKKSICYTLSTKIPEMSPFLMFVLAGIPLPLGTVTILCIDLGTDMV 817

  Fly   803 PATALGFNPPDLDIMEKPPRKA------DEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDE 861
            ||.:..:...:.|||::.||.|      :|.|:|    ..|..||  |..|..|...::.:.::.
Zfish   818 PAISFAYENAESDIMKRQPRNAATDRLVNERLVS----VSYGQIG--VMNAFGGFFTYFVILAEN 876

  Fly   862 G--PKLSYWQLTHHLSCLGGGDEFKGVDCKIFS---DPHAMTMALSVLVTIEMLNAMNSLSEN-- 919
            |  |    |.|..  ..:|..|.:       ||   |.:....      |.|....:......
Zfish   877 GFLP----WDLVG--LRIGWNDRY-------FSEVEDSYGQQW------TYEQRKVLEYTCHTAY 922

  Fly   920 -QSLITMPPWCNLWLIGSMALSF--------TLHFVIL----------YVDVLSTVFQVTPLSAE 965
             .|::.| .|..|.:..|..||.        .|.|.:.          |...:....::.||...
Zfish   923 FTSIVIM-QWTTLLVCKSRRLSLAKQGMKNRVLTFSLFEETAIAAFLSYCPGMDIAVRMYPLKPM 986

  Fly   966 EWITVMKFSIPVVLLDETLKFVARKIADG 994
            .|.....:.|.:.:.||..|...|:...|
Zfish   987 WWFCAFPYMILIFIYDEVRKHFIRQNPGG 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	316/1060 (30%)
atp1a1a.5	NP_835200.1	ATPase-IIC_X-K	32..1023	CDD:273445	319/1069 (30%)