DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and Atp4a

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_036641.1	Gene:	Atp4a / 24216	RGDID:	2177	Length:	1034	Species:	Rattus norvegicus

Alignment Length:	1075	Identity:	325/1075 - (30%)
Similarity:	500/1075 - (46%)	Gaps:	190/1075 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65
            |.| |..:|.:....:.|...:||..........:.|||.|....|...:.....|....|..::
  Rat    51 MND-HQLSVSELEQKYQTSATKGLKASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLM 114

  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVV----GVWQERNAESAIEALKEYEPEM 126
            .:||.|..:....:..|...|. .:.|.:.|.|||..||    |.:||..:.:.|.:.|...|:.
  Rat   115 WVAAAICLIAFAIQASEGDLTT-DDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQ 178

  Fly   127 GKVVRQ-DKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKH 190
            ..|:|. ||.   ::.|.::|.|||||:..||::||||||  :.:...::|.|.|||||....:
  Rat   179 ATVIRDGDKF---QINADQLVVGDLVEMKGGDRVPADIRI--LSAQGCKVDNSSLTGESEPQTR- 237

  Fly   191 TDAIPDPRAVNQ---DKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQK 252
                 .|...::   :.:||.|..|....|.|:|:|:.||..|.||:|.:..|..|..|||:
  Rat   238 -----SPECTHESPLETRNIAFFSTMCLEGTAQGLVVSTGDRTIIGRIASLASGVENEKTPI--- 294

  Fly   253 LDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIA--------------VALA 303
                                ||.|.||.|...|.:.:.||. :|.:|              :|:.
  Rat   295 --------------------AIEIEHFVDIIAGLAILFGAT-FFVVAMCIGYTFLRAMVFFMAIV 338

  Fly   304 VAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFI 368
            ||.:||||.|.:|.||:|..:|:|.||.:|::|.:|||||.|||||||||||||.|:|:||.::.
  Rat   339 VAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWF 403

  Fly   369 FDKVEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQA 433
            .:.:...|::   .:.:|.|::...|              |.:.|..:..:||.:|     ||..
  Rat   404 DNHIHTADTT---EDQSGQTFDQSSE--------------TWRALCRVLTLCNRAA-----FKSG 446

  Fly   434 FEKV--------GEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEF-----TL 485
            .:.|        |:|:||||:..:|....   |..|...|...:.   ||......:|     ||
  Rat   447 QDAVPVPKRIVIGDASETALLKFSELTLG---NAMGYRDRFPKVC---EIPFNSTNKFQLSIHTL 505

  Fly   486 EFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPL----TSALKAKIL 546
            |..||.:.:                 |.:|||||.|||||:...:...::||    ..|.:...|
  Rat   506 EDPRDPRHL-----------------LVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYL 553

  Fly   547 ALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFYQYEV--------NLTFVGVVGMLDPP 603
            :|.   |.|...|....|.:.:....|.          |.::|        .|.|.|:|.|:|||
  Rat   554 SLG---GLGERVLGFCQLYLNEKDYPPG----------YTFDVEAMNFPSSGLCFAGLVSMIDPP 605

  Fly   604 RKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDT--------------TGKS-- 652
            |..|.|::::||.||||||::|||:..||:||...:|:.:|..:|              ..|.
  Rat   606 RATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRMPVDQVNKKDA 670

  Fly   653 ----YSGREFDDLSPTEQKAAVAR--SRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPAL 711
                .:|.:..|:.|:|...|:..  ..:|:|..||.|..|||..|.:..|.|:|||||||:|||
  Rat   671 RACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPAL 735

  Fly   712 KKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVS- 774
            |||:||:||| :|:..||:||:|:|.||||:|||:.||:||.|::|:|:.|.|.::.||.|:..
  Rat   736 KKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPY 800

  Fly   775 -IFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRK------ADEGLISGW 832
             |::|.::.||...|.:  |::.|.||..|:.:|.:...:.|||...||.      .:|.| :.:
  Rat   801 LIYITVSVPLPLGCITI--LFIELCTDIFPSVSLAYEKAESDIMHLRPRNPRRDRLVNEPL-AAY 862

  Fly   833 LFFRYMAIGFYVGAA---TVGAAAWWFVFSDEGPKLSYWQLTHHLSCL--GGGDEFKGVDCKIFS 892
            .:|:..||..:.|.|   |..|...||.....|.: ..|: .|||..|  ..|.|:. ...:::.
  Rat   863 SYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGLR-PQWE-DHHLQDLQDSYGQEWT-FGQRLYQ 924

  Fly   893 DPHAMTMALSVLVTIEMLNAMNSL---SENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLS 954
            .....|:   ..::|||....:.|   :...|......:.|..|:.::.....:...:.|...:.
  Rat   925 QYTCYTV---FFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMP 986

  Fly   955 TVFQVTPLSAEEWITVMKFSIPVVLLDETLKFVAR 989
            .:|...|:..:.|:..|.|.:.:.:.||..|...|
  Rat   987 NIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVR 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	322/1069 (30%)
Atp4a	NP_036641.1	H-K_ATPase_N	2..>27	CDD:286172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..40
		ATPase-IIC_X-K	42..1034	CDD:273445	325/1075 (30%)
		Cation_ATPase_N	50..124	CDD:214842	17/73 (23%)
		E1-E2_ATPase	145..375	CDD:278548	86/264 (33%)
		Cation_ATPase	437..531	CDD:289987	35/121 (29%)
		COG4087	<687..>742	CDD:226572	27/54 (50%)
		Cation_ATPase_C	809..1018	CDD:279079	49/217 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920