DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and Atp1a2

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_036637.1	Gene:	Atp1a2 / 24212	RGDID:	2168	Length:	1020	Species:	Rattus norvegicus

Alignment Length:	1072	Identity:	320/1072 - (29%)
Similarity:	513/1072 - (47%)	Gaps:	179/1072 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLL 67
            |.|..::::....:..|..:|||..:.:....:.|||.|........|.....|.......:|.:
  Rat    40 DDHKLSLDELGRKYQVDLSKGLTNQRAQDILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWI 104

  Fly    68 AAIISF----VLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGK 128
            .|::.|    :||..|:.......:: .:|:..::|.......:||..:...:::.|...|:...
  Rat   105 GALLCFLAYGILAAMEDEPSNDNLYL-GIVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQAL 168

  Fly   129 VVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDA 193
            |:|:.:.  .::.|:|:|.||||||..||::|||:||  |.|...::|.|.|||||....:
  Rat   169 VIREGEK--MQINAEEVVVGDLVEVKGGDRVPADLRI--ISSHGCKVDNSSLTGESEPQTR---- 225

  Fly   194 IPDPRAVNQ---DKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDE 255
              .|...::   :.:||.|..||...|.|||:||.||..|.:|:|.|..|..|..:||:..:::.
  Rat   226 --SPEFTHENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGQTPIAMEIEH 288

  Fly   256 FGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLA 320
            |.:.::.|...:.|:.:.:::      ..|.||::..|:    .:.:.||.:||||.|.:|.||.
  Rat   289 FIQLITGVAVFLGVSFFVLSL------ILGYSWLEAVIF----LIGIIVANVPEGLLATVTVCLT 343

  Fly   321 LGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMT 385
            |..:|||:||.:|::|.:|||||.||.||||||||||.|:|:|:.|:..:::...|::   .:.:
  Rat   344 LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTT---EDQS 405

  Fly   386 GSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKV--------GEATE 442
            |:|::...              .|...||.|..:||.:.     ||...|.:        |:|:|
  Rat   406 GATFDKRS--------------PTWTALSRIAGLCNRAV-----FKAGQENISVSKRDTAGDASE 451

  Fly   443 TALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLG 507
            :||:...| |:..||.|  :..|:..:|   ||......::.|.......|..|:.
  Rat   452 SALLKCIE-LSCGSVRK--MRDRNPKVA---EIPFNSTNKYQLSIHEREDSPQSHV--------- 501

  Fly   508 TGPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY----GTGRDTLRCLALAVAD 568
                |.:|||||.:|:||:...|...::||...::.   |....|    |.|.   |.|.....:
  Rat   502 ----LVMKGAPERILDRCSTILVQGKEIPLDKEMQD---AFQNAYMELGGLGE---RVLGFCQLN 556

  Fly   569 SP-------MKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITG 626
            .|       .|.|..:|...|:      .|.|||::.|:||||..|.|::.:||:|||:||::||
  Rat   557 LPSGKFPRGFKFDTDELNFPTE------KLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTG 615

  Fly   627 DNKATAEAICRRIGVFAEDEDTTGKSYSGR---EFDDLSPTEQKAAVARSR-------------- 674
            |:..||:||.:.:|:.:|..:|. :..:.|   ....::|.|.||.|....
  Rat   616 DHPITAKAIAKGVGIISEGNETV-EDIAARLNIPVSQVNPREAKACVVHGSDLKDMTSEQLDEIL 679

  Fly   675 ------LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAE 732
                  :|:|..||.|..|||..|....|.|:|||||||:||||||:|||||| ||:.|:|.||:
  Rat   680 RDHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAAD 744

  Fly   733 MVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNL 797
            |:|.||||:|||:.|||||.|::|:|:.|.|.::|||.|:....|.....:|..|..|.:|.::|
  Rat   745 MILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDL 809

  Fly   798 VTDGLPATALGFNPPDLDIMEKPPRKA------DEGLIS------GWL-----FFRYMAI----G 841
            .||.:||.:|.:...:.|||::.||.:      :|.|||      |.:     ||.|..|    |
  Rat   810 GTDMVPAISLAYEAAESDIMKRQPRNSQTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENG 874

  Fly   842 FYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKI--FSDPHAMTMALSVL 904
            | :.:..:|....|...:....:.||            |.|:.....|:  |:...|...::.|:
  Rat   875 F-LPSRLLGIRLDWDDRTTNDLEDSY------------GQEWTYEQRKVVEFTCHTAFFASIVVV 926

  Fly   905 VTIEML---NAMNSL----SENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPL 962
            ...:::   ...||:    .:|:.||       ..|:...||:..|.    |...:....::.||
  Rat   927 QWADLIICKTRRNSVFQQGMKNKILI-------FGLLEETALAAFLS----YCPGMGVALRMYPL 980

  Fly   963 SAEEWITVMKFSIPVVLLDETLKFVARKIADG 994
            ....|.....:|:.:.:.||..|.:.|:...|
  Rat   981 KVTWWFCAFPYSLLIFIYDEVRKLILRRYPGG 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	317/1063 (30%)
Atp1a2	NP_036637.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		ATPase-IIC_X-K	30..1020	CDD:273445	320/1072 (30%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..231		8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920