Protein Alignment SERCA and Atp1a1

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_036636.1
• Gene: Atp1a1 / 24211
• RGDID: 2167
• Length: 1023
• Species: Rattus norvegicus
• Alignment Length: 1079
• Identity: 327/1079 - (30%)
• Similarity: 513/1079 - (47%)
• Gaps: 192/1079 - (17%)

  Fly     3 DGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLL 67
            |.|..::::....:|||..||||..:......:.|||.|........|.....|.......:|.:
  Rat    42 DDHKLSLDELHRKYGTDLSRGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWI 106

  Fly    68 AAIISF----VLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGK 128
            .||:.|    :.:..||.......:: .:|:..::|.......:||..:...:|:.|...|:...
  Rat   107 GAILCFLAYGIRSATEEEPPNDDLYL-GVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQAL 170

  Fly   129 VVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDA 193
            |:|..:.  ..:.|:::|.||||||..||:||||:||  |.:...::|.|.|||||....:
  Rat   171 VIRNGEK--MSINAEDVVVGDLVEVKGGDRIPADLRI--ISANGCKVDNSSLTGESEPQTR---- 227

  Fly   194 IPDPRAVNQ---DKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDE 255
              .|...|:   :.:||.|..||...|.|||:|:.||..|.:|:|.|..|..|..:||:.::::.
  Rat   228 --SPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAEEIEH 290

  Fly   256 FGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLA 320
            |...::.|...:.|:.:.:::      ....:|::..|:    .:.:.||.:||||.|.:|.||.
  Rat   291 FIHLITGVAVFLGVSFFILSL------ILEYTWLEAVIF----LIGIIVANVPEGLLATVTVCLT 345

  Fly   321 LGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDS----SFLE 381
            |..:|||:||.:|::|.:|||||.||.||||||||||.|:|:|:.|:..:::...|:    |.:.
  Rat   346 LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVS 410

  Fly   382 FEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNE-----FKQAFEKVGEAT 441
            |:.|.:|:                     ..||.|..:||.:....|:     .|:|.  .|:|:
  Rat   411 FDKTSATW---------------------FALSRIAGLCNRAVFQANQENLPILKRAV--AGDAS 452

  Fly   442 ETALIVLAEKLNSFSVNKSGLDRRSAAIACRG---EIETKWKKEFTLEFSRDRKSMSSYCTPLKA 503
            |:||:...|                   .|.|   |:..|:.|...:.|:    |.:.|...:..
  Rat   453 ESALLKCIE-------------------VCCGSVMEMREKYTKIVEIPFN----STNKYQLSIHK 494

  Fly   504 SRLGTGPK--LFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY----GTGRDTLRCL 562
            :...:.||  |.:|||||.:|:||:...:...:.||...||.   |....|    |.|...|...
  Rat   495 NPNASEPKHLLVMKGAPERILDRCSSILLHGKEQPLDEELKD---AFQNAYLELGGLGERVLGFC 556

  Fly   563 ALAVADSPMKPDEMDLGDSTKFYQYEV-----NLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVI 622
            .|      :.||| ...:..:|...||     ||.|||::.|:||||..|.|::.:||:|||:||
  Rat   557 HL------LLPDE-QFPEGFQFDTDEVNFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVI 614

  Fly   623 VITGDNKATAEAICRRIGVFAEDEDTTGKSYSGR---EFDDLSPTEQKAAVARSR---------- 674
            ::|||:..||:||.:.:|:.:|..:|. :..:.|   ..:.::|.:.||.|....
  Rat   615 MVTGDHPITAKAIAKGVGIISEGNETV-EDIAARLNIPVNQVNPRDAKACVVHGSDLKDMTSEEL 678

  Fly   675 ----------LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAK 728
                      :|:|..||.|..|||..|....|.|:|||||||:||||||:||:||| .|:.|:|
  Rat   679 DDILRYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDVSK 743

  Fly   729 SAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVS--IFLTAALGLPEALIPVQ 791
            .||:|:|.||||:|||:.|||||.|::|:|:.|.|.::|||.|:..  ||:.|.:.||  |..|.
  Rat   744 QAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLP--LGTVT 806

  Fly   792 LLWVNLVTDGLPATALGFNPPDLDIMEKPPR--KAD----EGLISGWLFFRYMAIGFYVGAATVG 850
            :|.::|.||.:||.:|.:...:.|||::.||  |.|    |.|||       ||.|.......:|
  Rat   807 ILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLIS-------MAYGQIGMIQALG 864

  Fly   851 AAAWWFVFSDEGPKLSYWQLTHHLSCLG----------------GGDEFKGVDCKI--FSDPHAM 897
            ....:||...|...|.:     ||  ||                .|.::.....||  |:...|.
  Rat   865 GFFTYFVILAENGFLPF-----HL--LGIRETWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAF 922

  Fly   898 TMALSVLVTIEML---NAMNSL----SENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLST 955
            .:::.|:...:::   ...||:    .:|:.||       ..|....||:..|.    |...:..
  Rat   923 FVSIVVVQWADLVICKTRRNSVFQQGMKNKILI-------FGLFEETALAAFLS----YCPGMGA 976

  Fly   956 VFQVTPLSAEEWITVMKFSIPVVLLDETLKFVARKIADG 994
            ..::.||....|.....:|:.:.:.||..|.:.|:...|
  Rat   977 ALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGG 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	324/1070 (30%)
Atp1a1	NP_036636.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		ATPase-IIC_X-K	29..1023	CDD:273445	327/1079 (30%)
		Phosphoinositide-3 kinase binding	82..84		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..235		8/24 (33%)
		Mediates interaction with SCN7A. /evidence=ECO:0000250|UniProtKB:Q8VDN2	596..717		37/121 (31%)