Protein Alignment SERCA and Atp1a3

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_001407721.1
• Gene: Atp1a3 / 232975
• MGIID: 88107
• Length: 1066
• Species: Mus musculus
• Alignment Length: 1081
• Identity: 318/1081 - (29%)
• Similarity: 513/1081 - (47%)
• Gaps: 182/1081 - (16%)

  Fly     5 HSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAA 69
            |..:||:....:.||..:|||..:.:....:.|||.|........|.....|.......:|.:.|
Mouse    47 HKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGA 111

  Fly    70 IISFV---LALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVR 131
            |:.|:   :....|.:.:.......:|:..::|.......:||..:...:|:.|...|:...|:|
Mouse   112 ILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIR 176

  Fly   132 QDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPD 196
            :.:.  .:|.|:|:|.|||||:..||::|||:||  |.:...::|.|.|||||....:..|...|
Mouse   177 EGEK--MQVNAEEVVVGDLVEIKGGDRVPADLRI--ISAHGCKVDNSSLTGESEPQTRSPDCTHD 237

  Fly   197 PRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS 261
            ...   :.:||.|..||...|.|||||:.||..|.:|:|.|..|..|..|||:..:::.|.:.::
Mouse   238 NPL---ETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLIT 299

  Fly   262 KVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM 326
            .|...:.|:.:.:::      ..|.:|::..|:    .:.:.||.:||||.|.:|.||.|..:||
Mouse   300 GVAVFLGVSFFILSL------ILGYTWLEAVIF----LIGIIVANVPEGLLATVTVCLTLTAKRM 354

  Fly   327 AKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEP 391
            |:||.:|::|.:|||||.||.||||||||||.|:|:|:.|:..:::...|::   .:.:|::::.
Mouse   355 ARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTT---EDQSGTSFDK 416

  Fly   392 IGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKV--------GEATETALIVL 448
            ....::              .||.|..:||.:.     ||...:.:        |:|:|:||:..
Mouse   417 SSHTWV--------------ALSHIAGLCNRAV-----FKGGQDNIPVLKRDVAGDASESALLKC 462

  Fly   449 AEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTL-----EFSRDRKSMSSYCTPLKASRLGT 508
            .| |:|.||..  :..|:..:|   ||......::.|     |...|.:.:
Mouse   463 IE-LSSGSVKL--MRERNKKVA---EIPFNSTNKYQLSIHETEDPNDNRYL-------------- 507

  Fly   509 GPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY----GTGRDTLRCLALAVADS 569
               |.:|||||.:|:||....:...:.||...:|.   |....|    |.|...|......:
Mouse   508 ---LVMKGAPERILDRCATILLQGKEQPLDEEMKE---AFQNAYLELGGLGERVLGFCHYYL--- 563

  Fly   570 PMKPDEM----------DLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVI 624
               |:|.          |:..:|.      ||.|||::.|:||||..|.|::.:||:|||:||::
Mouse   564 ---PEEQFPKGFAFDCDDVNFTTD------NLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMV 619

  Fly   625 TGDNKATAEAICRRIGVFAEDEDTTGKSYSGR---EFDDLSPTEQKAAVARSR------------ 674
            |||:..||:||.:.:|:.:|..:|. :..:.|   ....::|.:.||.|....
Mouse   620 TGDHPITAKAIAKGVGIISEGNETV-EDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDE 683

  Fly   675 --------LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSA 730
                    :|:|..||.|..|||..|....|.|:|||||||:||||||:||:||| :|:.|:|.|
Mouse   684 ILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQA 748

  Fly   731 AEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWV 795
            |:|:|.||||:|||:.|||||.|::|:|:.|.|.::|||.|:....|.....:|..|..:.:|.:
Mouse   749 ADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCI 813

  Fly   796 NLVTDGLPATALGFNPPDLDIMEKPPRK------ADEGLIS------GWL-----FFRYMAI--- 840
            :|.||.:||.:|.:...:.|||::.||.      .:|.|||      |.:     ||.|..|
Mouse   814 DLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAE 878

  Fly   841 -GFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVL 904
             ||..| ..||....|...:....:.||.|...:       ::.|.|:   |:...|..:::.|:
Mouse   879 NGFLPG-NLVGIRLNWDDRTVNDLEDSYGQQWTY-------EQRKVVE---FTCHTAFFVSIVVV 932

  Fly   905 VTIEML---NAMNSL----SENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPL 962
            ...:::   ...||:    .:|:.||       ..|....||:..|.    |...:....::.||
Mouse   933 QWADLIICKTRRNSVFQQGMKNKILI-------FGLFEETALAAFLS----YCPGMDVALRMYPL 986

  Fly   963 SAEEWITVMKFSIPVVLLDETLKFVARKIADGESPIYKMHG 1003
            ....|.....:|..:.:.||..|.:.|:...||..:.:..|
Mouse   987 KPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGEGRMARGKG 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	314/1065 (29%)
Atp1a3	NP_001407721.1	ATPase-IIC_X-K	31..1018	CDD:273445	315/1070 (29%)