Protein Alignment SERCA and Atp13a3

DIOPT Version :9

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_001121568.1
• Gene: Atp13a3 / 224088
• MGIID: 2685387
• Length: 1249
• Species: Mus musculus
• Alignment Length: 1147
• Identity: 243/1147 - (21%)
• Similarity: 431/1147 - (37%)
• Gaps: 320/1147 - (27%)

  Fly    23 GLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEEHEETFTA 87
            |||.......:..||.||:..:. .|:::|::::    ::....:..:.|.:|...:|:
Mouse   174 GLTQGMHAYRKLIYGVNEIAVKV-PSVFKLLIKE----VLNPFYIFQLFSVILWSVDEY------ 227

  Fly    88 FVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRAKEIVPGDLVE 152
            :...|.|:::.:.:.:..::..|.....:..:......:...|.::...|:::.:.::||||::.
Mouse   228 YYYALAIVIMSVVSIISSLYSIRKQYVMLHDMVATHSTVRVSVCRENEEIEEIFSTDLVPGDVMI 292

  Fly   153 VSV-GDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDP----RAVNQD-------KK 205
            :.: |..:|.|   ..:.:.|..:::|:||||||.|.|..  :|:|    :.:.::       |:
Mouse   293 IPLNGTVMPCD---AVLINGTCIVNESMLTGESVPVTKTN--LPNPSVDVKGMGEEQYSPETHKR 352

  Fly   206 NILFSGTNVAAGK------ARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSKVI 264
            :.||.||.|...:      .:.:|:.||.||:.|::         :::.|..|..:|.......:
Mouse   353 HTLFCGTTVIQTRFYTGELVKAIVVRTGFSTSKGQL---------VRSILYPKPTDFKLYRDAYL 408

  Fly   265 SVICVAVWAINIGH--------FNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLAL 321
            .::|:.|.| .||.        .|:.......||        ::.:....:|..|||.:|..:..
Mouse   409 FLLCLVVVA-GIGFIYTIINSILNEKEVQEIIIK--------SLDIITITVPPALPAAMTAGIVY 464

  Fly   322 GTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTG 386
            ..||:.|......|...:...|..:::|.|||||||.:.:.   ::...:||  ::.||..|
Mouse   465 AQRRLKKVGIFCISPQRINICGQLNLVCFDKTGTLTEDGLD---LWGIQRVE--NTRFLLPE--- 521

  Fly   387 STYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVG----EATETALIV 447
              .....|:.:..|.:  |...|...|:.|..:.:...:|.    :.||.:|    ||||
Mouse   522 --DNVCSEMLVKSQFV--ACMATCHSLTKIEGVLSGDPLDL----KMFEAIGWILEEATE----- 573

  Fly   448 LAEKLNSFSVNKSGLDRRSAAIACR------GEIETKWKKEFTL---------------EFSRDR 491
                      .::.|..|......|      .|..|...:|..|               .||...
Mouse   574 ----------EETALHNRIMPTVVRPSKQLLPEPTTAGNQEMELFELPAIYEIGIVRQFPFSSAL 628

  Fly   492 KSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGR 556
            :.||.....|...|:..    ::|||||.|...|   :..|..|.....|:        .|  .:
Mouse   629 QRMSVVARTLGEKRMDA----YMKGAPEVVASLC---KPETVPVDFEKVLE--------DY--TK 676

  Fly   557 DTLRCLALAVADSPMKPDEMDLGDSTKFYQ--------YEVNLTFVGVVGMLDPPRKEVFDSIVR 613
            ...|.:|||         ...|.....:::        .|.|:.|:|::.|.:..::|....:..
Mouse   677 QGFRVIALA---------HRKLESKLTWHKVQHISRDAIENNMDFMGLIIMQNKLKQETPAVLED 732

  Fly   614 CRAAGIRVIVITGDNKATAEAICRRIGVF------------------------------------ 642
            ...|.||.:::||||..||.::.|..|:.
Mouse   733 LHKANIRTVMVTGDNMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHYTDSLSQCSES 797

  Fly   643 ----------------AEDEDTT-------GKSYSG--REFDDLSPTEQKAAVARSRLFSRVEPQ 682
                            .||.:.|       |||:|.  ..|.||.|    ..:....:|:|:.|.
Mouse   798 SAIDSEAIPIKLAHDSLEDLEVTRYHFAMNGKSFSVILEHFQDLVP----KLMLHGTVFARMAPD 858

  Fly   683 HKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAV 747
            .|:::||.||:::....|.|||.||..|||:|..||::..  ..|..|:.......:.|.:.:.:
Mouse   859 QKTQLVEALQNVDYFVGMCGDGANDCGALKRAHGGISLSE--LEASVASPFTSKTPSISCVPNLI 921

  Fly   748 EEGR-------------AIYNNMKQF---IRYLISSNIGEVVSIFLTAALGL----PEALIPVQL 792
            .|||             |:|:.::.|   :.|.|.||:|:...:|:..|:.|    ..:|.|.
Mouse   922 REGRAALMTSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLAIILVVVFTMSLNPA-- 984

  Fly   793 LWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMA-IGFYVGAATVGAAAWW- 855
             |..||.                  ::||    .|||||.|.|..:: |...||..::|  .:|
Mouse   985 -WKELVA------------------QRPP----SGLISGALLFSVLSQIVISVGFQSLG--FFWV 1024

  Fly   856 --FVFSDEG------PKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNA 912
              :...|..      .:.:.|..:|    |..|.|..  .|||.:..:.....:|   :.:.|..
Mouse  1025 KQYKVCDPNSDVCNTTRSACWNSSH----LYNGTELD--SCKIQNYENTTVFFIS---SFQYLTV 1080

  Fly   913 MNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVL-------STVFQVTPLSA--EEW- 967
            ..:.|:.:. ...|.:.|.:        |.:..:||||.:|       ::|.||..:..  .:|
Mouse  1081 AVAFSKGKP-FRQPCYKNYF--------FVISVIILYVFILFIMLHPVASVDQVLEIMCVPYQWR 1136

  Fly   968 --------------ITVMKFSIPVVLLDETLKFVARKIADGE 995
                          |||..|.:..||    .|.|..:...||
Mouse  1137 IYMLIIVLINAFVSITVESFFLDTVL----WKVVFNRDKQGE 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	241/1139 (21%)
Atp13a3	NP_001121568.1	P-ATPase-V	14..1142	CDD:273738	233/1109 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910