DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERCA and Atp13a4

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_001158084.1	Gene:	Atp13a4 / 224079	MGIID:	1924456	Length:	1193	Species:	Mus musculus

Alignment Length:	1069	Identity:	217/1069 - (20%)
Similarity:	359/1069 - (33%)	Gaps:	394/1069 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEEHEETFTA 87
            |||.::.:..:...|||.:..|. ..||:|::::    ::....:..:.|..|...|:::|
Mouse   170 GLTSEEQEIRRLICGPNAIDVEI-TPIWKLLIKE----VLNPFYIFQLFSVCLWFSEDYKE---- 225

  Fly    88 FVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRAKEIVPGDLVE 152
              ..|.|:|:.:.:..:.|:..|.....:..|.|....:...|.:.|:|.|.:.::.:|||||:
Mouse   226 --YALAIILMSVISIALTVYDLRQQSVKLHHLVESHNSITVSVYERKAGAQDLESRLLVPGDLL- 287

  Fly   153 VSVGDKI--PADIRITHIYSTTLRIDQSILTGESVSVIK-----HTDAIP-------DPRAVNQD 203
            :..|.::  |.|   ..:...:..:|:.:|||||:.|.|     ...::|       |||
Mouse   288 ILTGSRVQMPCD---AILIDGSCVVDEGMLTGESIPVTKTPLSQTASSVPWKMQSEADPR----- 344

  Fly   204 KKNILFSGTNVAAGKA------RGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSK 262
             :::||.||.|...||      |.||:.||.:||.|.:         :::.|..|...|......
Mouse   345 -RHVLFCGTEVIQAKAAGSGAVRAVVLQTGFNTAKGDL---------VRSILYPKPMNFKLYRDA 399

  Fly   263 VISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKI--------------AVALAVAAIPEGLPA 313
            :..::|:.               |:...|.:|...:              |:.:...|:|..|||
Mouse   400 IRFLLCLV---------------GTATIGMVYTLCVYVLSGEPPEEVVRKALDVITIAVPPALPA 449

  Fly   314 VITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQM----------------- 361
            .:||.:....||:.||.....|...:...|..:::|.|||||||...:
Mouse   450 ALTTGIIYAQRRLKKKGIFCISPQRINVCGQLNLVCFDKTGTLTRGGLDPWGVVPCDQNGFQAVH 514

  Fly   362 ------------------SVSRMFIFD-KVEGNDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADY 407
                              |...:.:.| .::|:......||.|.......|:.|    .||....
Mouse   515 SFASGKALPQGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATKWEMTASGDDF----HIKEMLA 575

  Fly   408 DTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKL---NSFSVNKSGLDRRSAAI 469
            .|:                          |.:.|:....|.||.|   :.|..: |.|.|.:..:
Mouse   576 HTI--------------------------VVKPTDMVAQVPAEGLAIVHQFPFS-SALQRMTVIV 613

  Fly   470 ACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERCTHARVGTTK 534
                                              ..:|.|...|:|||||.|...|.     ...
Mouse   614 ----------------------------------QEMGGGRLAFMKGAPERVASFCQ-----PDT 639

  Fly   535 VPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFYQ-YEVNLTFVGVV- 597
            ||.:...:.:|....|        .|.:|||     .|..|||...:....: .|.:|.|:|::
Mouse   640 VPTSFISELQIYTTQG--------FRVIALA-----YKKLEMDCPTTALMREKVESDLVFLGLLI 691

  Fly   598 --GMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAE---------------- 644
              ..|....|.|.:.::..|   ||.::|||||..||..:.|:.|:.:|
Mouse   692 LENRLKEETKPVLEELISAR---IRTVMITGDNLQTAITVARKSGMVSEGQKVILVEANEATGSS 753

  Fly   645 ------------------DEDT---------------------TGKSYS--GREFDDLSPTEQKA 668
                              .:||                     :|||:.  .:.|..|.|    .
Mouse   754 SASISWKLVEEKKPGPFGSQDTYINIREEVPENGRDGSYHFALSGKSFHVISQYFSSLLP----K 814

  Fly   669 AVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEM 733
            .:....:|:|:.|..||.:||..|.::....|.|||.||..|||.|.:||::..  ..|..|:..
Mouse   815 ILINGTIFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGALKMAHVGISLSE--QEASVASPF 877

  Fly   734 VLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLV 798
            .....|...:...::||||
Mouse   878 TSKTPNIECVPHLIKEGRA---------------------------------------------- 896

  Fly   799 TDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGF---YVGAATVGAAAWWFVFSD 860
                                        .|::.:..|:|||:..   |||..
Mouse   897 ----------------------------ALVTSFCMFKYMALYSMIQYVGVL------------- 920

  Fly   861 EGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSENQSLITM 925
                |.||: |:.||    ..:|      :|.|     :|::.|:.:    .||....|..|:..
Mouse   921 ----LLYWK-TNSLS----NYQF------LFQD-----LAITTLIGV----TMNLNGANPKLVPF 961

  Fly   926 --------PPWCNLWLIGSMALSFTLHFV 946
                    ||.. |.::.::.||..:|.|
Mouse   962 RPAGRLISPPLL-LSVVLNILLSLAMHIV 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	217/1069 (20%)
Atp13a4	NP_001158084.1	P-ATPase-V	18..1115	CDD:273738	217/1069 (20%)
		P5-ATPase	18..137	CDD:289194
		Cation_ATPase_N	<170..218	CDD:279080	11/52 (21%)
		E1-E2_ATPase	228..472	CDD:278548	65/277 (23%)
		Cation_ATPase	<596..635	CDD:289987	13/73 (18%)
		COG4087	<821..>870	CDD:226572	20/50 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910