Protein Alignment SERCA and mca-2

DIOPT Version :9

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_500161.1
• Gene: mca-2 / 177004
• WormBaseID: WBGene00019875
• Length: 1158
• Species: Caenorhabditis elegans
• Alignment Length: 1099
• Identity: 311/1099 - (28%)
• Similarity: 491/1099 - (44%)
• Gaps: 239/1099 - (21%)

  Fly    18 TDPERGLTLD--QIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFE- 79
            |||..||..|  :::..:..:|.||:|....||.::|..|...|:.:.|||:||::|..|:.::
 Worm    45 TDPINGLPNDTKELEHRRTAFGKNEIPPAPSKSFFRLAWEALQDITLVILLVAALVSLGLSFYKP 109

  Fly    80 --EH-----EETFTAFVEPLVIL---LILIANAVVGVW----QERNAESAIEALKEYEPEMGKVV 130
              ||     .|:...::|.:.||   |:::....:..|    |.|..:|.||...::     .|:
 Worm   110 PAEHASNDSSESEAGWIEGVAILVAVLVVVLVTALNDWTKEKQFRGLQSKIETEHKF-----SVI 169

  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195
            |..:.  ..:...|:|.||:..|..||.:|||..:  |.|..|:||:|.||||| .:|:.::..
 Worm   170 RGGEP--LDIVVNELVVGDIARVKYGDLLPADGLL--IQSNDLKIDESSLTGES-DLIRKSEEF- 228

  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRT----------------------- 237
            ||         :|.|||:...|..|.:|...||::..|.|.:
 Worm   229 DP---------VLLSGTHAMEGSGRFLVTAVGLNSQTGIIMSLLGAAKEKKDDKKEEPTTLTNGN 284

  Fly   238 ---------------EMSETEEI----KTPLQQKLDEFGEQLSKVISVI------------CVAV 271
                           .:.|.||:    |:.||.||.....|:..:.|::            |::.
 Worm   285 HMNGLGNGVDKAAELPVPEEEEVGRMSKSVLQTKLSNLALQIGYIGSIVAAATVLILIIRHCISK 349

  Fly   272 WAI--------NIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAK 328
            :||        :|.||             :.:..|.|.:.|.|:|||||..||..|....::|.|
 Worm   350 YAIEGKSFEASDISHF-------------VNFIIIGVTVLVIAVPEGLPLAITLALTYSVKKMMK 401

  Fly   329 KNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDK-VEGNDSSFLEFEMTGSTYEPI 392
            .|.:||.|.:.||:|..:.||||||||||||:|:..:.:|..: .:||...:  .:|..||
 Worm   402 DNNLVRHLDACETMGNATSICSDKTGTLTTNRMTCVQQYINSEFYKGNAPKY--EQMDPST---- 460

  Fly   393 GEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFSV 457
            .::..||..|.:. |:     ||:....|..        :...::|..||.:|:..        :
 Worm   461 RDILFNGIVINSG-YN-----STVVTPKNPG--------EQRGQIGNKTECSLLGF--------I 503

  Fly   458 NKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGP-KLFVKGAPEGV 521
            ..||   ||.....|...|.|..|.:|  |:..||||      :....||... :::.|||.|.:
 Worm   504 MDSG---RSYEDLRRQFPEEKLYKVYT--FNSSRKSM------MTVIELGDKKYRIYAKGASEII 557

  Fly   522 LERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKP------------- 573
            |.||.:....:.|:......:|.::..........|.||.:.||..|  :.|
 Worm   558 LTRCNYIFGKSGKIEQFGPKEAAVMTKNVIEPMASDGLRTIGLAFKD--LVPAGSKKYEYEEEYD 620

  Fly   574 DEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRR 638
            .|:|..|..|..:.:   |.:.|:|:.||.|.||..:|.:|:.|||.|.::||||..||.:|..:
 Worm   621 GEIDWEDEEKIREGQ---TVIAVMGIQDPVRPEVPAAIAKCQKAGITVRMVTGDNINTARSIATQ 682

  Fly   639 IGVFAEDED---TTGKSYSGREFD-DLSPTEQK--AAVARSRLFSRVEPQHK----SKIVEFLQS 693
            .|:.....|   ..||.::.|..| |....:||  |...:.|:.:|.:|..|    ..|:|...:
 Worm   683 CGIMQPGGDFLALEGKEFNARIRDADGKVNQQKFDAIWPKLRVLARAQPSDKYVLVKGIIESTVT 747

  Fly   694 MN-EISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNN 756
            .| |:.|:||||.|||||||||::|.||| :||.|||.|::::|.||||||||.||..||.:|::
 Worm   748 KNREVVAVTGDGTNDAPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS 812

  Fly   757 MKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPP 821
            :.:|:::.::.|:..|...|:.|.......|..||:|||||:.|.|.:.||....|..|::.:.|
 Worm   813 IAKFLQFQLTVNVVAVTIAFIGACAISDSPLKAVQMLWVNLIMDTLASLALATEMPTEDLLNRKP 877

  Fly   822 RKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEF--- 883
            ....:.|||     |.| :...||.|....|   .:|:     :.:|           ||:.
 Worm   878 YGRTKSLIS-----RTM-VKNIVGHAVYQLA---ILFA-----IMFW-----------GDKLIPN 917

  Fly   884 --KGVDCKIFSDPHA-MTMALSVLVTIEMLNAMNSLSEN------QSLITMPPWCNLWLIGSMAL 939
              .|.:.::.|.|.| .|:..:..|.:.::|.:|:...:      :.:.|.|.:|.:|:.
 Worm   918 TPSGRNAELGSPPSAHFTIIFNAFVLMTLVNEINARKIHGERNVFKGIFTNPIFCVIWIT----- 977

  Fly   940 SFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFS------------IPVVLLDETLKF 986
              ||...||.|......|...||...:||..:...            ||..:|.::.:|
 Worm   978 --TLISHILIVQFGGQWFSTAPLDLTQWIICICCGVGELFWGQIINCIPASILPKSFRF 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	311/1099 (28%)
mca-2	NP_500161.1	ATPase-IIB_Ca	5..1026	CDD:273668	309/1089 (28%)
		Cation_ATPase_N	35..101	CDD:279080	20/55 (36%)
		E1-E2_ATPase	168..413	CDD:278548	71/272 (26%)
		Cation_ATPase	475..564	CDD:289987	30/120 (25%)
		HAD	<648..767	CDD:289480	44/118 (37%)
		Cation_ATPase_C	841..1020	CDD:279079	50/210 (24%)
		ATP_Ca_trans_C	1073..>1096	CDD:289209

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920