Protein Alignment SERCA and catp-4

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_497034.2
• Gene: catp-4 / 175120
• WormBaseID: WBGene00007248
• Length: 1015
• Species: Caenorhabditis elegans
• Alignment Length: 1086
• Identity: 299/1086 - (27%)
• Similarity: 483/1086 - (44%)
• Gaps: 186/1086 - (17%)

  Fly     3 DGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLL 67
            |.|...::.....:.|..:.|::..:......:.|||.|...:..|.|..:..........:|..
 Worm    24 DDHEIPLDALFKRYTTSEKNGISEAEATNRLNRDGPNALTPPKQTSKWIKLAGSIFGGFNFLLWC 88

  Fly    68 AAIISFV-----LALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMG 127
            ||..|.|     |::.::.|.........:::..::....:...:|.|.:.:.:::.....|...
 Worm    89 AASASAVGYGMDLSMSDDEEVPKDNMYMAIILATVVTVTGLFDFYQNRKSGNLMDSFANMIPPKT 153

  Fly   128 KVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTD 192
            .|||.  ...:::..|::|.||||....||::|||:|:|  .:..|::|.|.|||||.
 Worm   154 LVVRD--GATREIEVKDLVVGDLVRFRGGDRVPADLRVT--LARGLKVDNSSLTGESE------- 207

  Fly   193 AIPDPRAVNQDKKNIL-------FSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQ 250
              |..|.:|...||.|       || |:|..|...|::||||..|.:|:|....::.:...|||.
 Worm   208 --PQTRNMNCTSKNALETKNLCMFS-TSVLEGSGEGIIIGTGDRTFVGRIAALTTQVDPGPTPLA 269

  Fly   251 QKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVI 315
            ::::.|.:.:|.|...:.:|.:.:.:.:...|      :|..:::    :.:.||.:|||:...:
 Worm   270 KEINHFIKIISIVAFTVGIAFFILALVYEYPP------LKAIVFF----MGIVVANVPEGIVPTV 324

  Fly   316 TTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFL 380
            |..|.|...:|.||..:|:.|.:|||||.||.||||||||||.|:|:|:.::...|::  |:..|
 Worm   325 TVSLTLTAVKMRKKFCLVKKLQAVETLGSTSTICSDKTGTLTQNRMTVTHLWFDGKIK--DTEIL 387

  Fly   381 EFEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEK---VGEATE 442
                      |..:.| .|:: |....|:.|:|.....:|:.|.....||.....|   .|:|:|
 Worm   388 ----------PPNDHF-KGEK-KYEKEDSYQKLLRCATLCSRSHFRVPEFDVPLAKRVVNGDASE 440

  Fly   443 TALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLG 507
            .|::...|.:.    ....:|.....:...|||......::.|......|..:.
 Worm   441 VAIMRYCEMIR----GDGQVDEFRKIMPKIGEIPFNSTNKYQLSIHPMSKKQNI----------- 490

  Fly   508 TGPKLFVKGAPEGVLERC-THARVGTTKVPLTSALK--AKILALTGQYGTGRDTLRCLALAVADS 569
                |.:|||||.:|:.| |:.:.|.||.......|  .:.....|.||.       ..|...|.
 Worm   491 ----LVMKGAPEKILKLCSTYYQNGETKNVSKKFEKEFQQAYETLGSYGE-------RVLGFCDL 544

  Fly   570 PMKPDEMDLGDSTKF---YQYEV--------NLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIV 623
            .|        .:|||   :::.:        ||.|:|::.|:||||..|.:::..|:.|||||::
 Worm   545 EM--------STTKFPPGFKFNMEEPNFPIKNLRFLGLISMIDPPRPGVPEAVRVCQNAGIRVVM 601

  Fly   624 ITGDNKATAEAICRRIGVFAEDEDTT-----------------GKS---------YSGREFDDLS 662
            :|||:..||.||..::.:..|:...|                 ||.         ..|.:...:|
 Worm   602 VTGDHPITARAIANQVHIIEENVQVTEIVNADPKCDPASDEIYGKGRLKPTGAVVIHGEQLTTMS 666

  Fly   663 PTEQKAAVARSR--LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGT 724
            |...||.|....  :|:|..|..|.:|||..||:..|..:|||||||||||:||:|||||| :||
 Worm   667 PKTLKAVVTNYHQIVFARTSPAQKLQIVEAFQSVGNIVGVTGDGVNDAPALRKADIGIAMGITGT 731

  Fly   725 AVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIP 789
            .|:|.||:|:|.:|||:|||:.|||||.|::|:|:.|.|.::|||.|:.........|||..:..
 Worm   732 DVSKQAADMILLNDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFMSYVLFGLPLPMSI 796

  Fly   790 VQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKA--DEGLISGWLFFRYMAIG----------F 842
            :.:|.::|.||..||.:..:..|:.|||::.||..  |:.:....:.|.||.||          :
 Worm   797 IAILMIDLGTDLWPAISFAYEVPESDIMQRAPRNPLYDKLVNKRLVMFSYMQIGAIQACAGFTTY 861

  Fly   843 YVGAATVGAAAWWF-------------VFSDE-----GPKLSYWQLTHHLSCLGGGDEFKGVDCK 889
            :|...:.|    ||             .:.|:     |.:.||.......||..|
 Worm   862 FVLMMSNG----WFPQDLLNISEQWDNKYIDDLEDSYGQQWSYESRKALESCCYG---------- 912

  Fly   890 IFSDPHAMTMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLS 954
                    |...:::|| :..:...|.:...||: |....|..|..|:..:..|...:|....::
 Worm   913 --------TFFFTIVVT-QWSDLFASKTRKNSLV-MQGMENHVLNTSVIFTCFLAIFVLNTPFVN 967

  Fly   955 TVFQVTPLSAEEWITVMKFSIPVVLLDETLKFVARKIADGESPIYK 1000
            .|..|.....|.....:.|:..:.|.||..::..|....|.  |||
 Worm   968 EVLGVQGFRLEIGFLALPFAFFIGLYDEVRRYFIRTYPGGY--IYK 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	293/1071 (27%)
catp-4	NP_497034.2	P-type_ATPase_Na-K_like	44..1012	CDD:319794	296/1066 (28%)