Protein Alignment SERCA and pmr-1

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_001021862.1
• Gene: pmr-1 / 173176
• WormBaseID: WBGene00004063
• Length: 978
• Species: Caenorhabditis elegans
• Alignment Length: 991
• Identity: 317/991 - (31%)
• Similarity: 508/991 - (51%)
• Gaps: 153/991 - (15%)

  Fly    18 TDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEEHE 82
            |:.|.|||..:....::.:|.||....|.:.|::..||||.:.|:.:||.:|.:|.|:   ::::
 Worm   101 TNLEEGLTTAEATRRRQYHGYNEFDVGEEEPIYKKYLEQFQNPLILLLLASAFVSIVM---KQYD 162

  Fly    83 ETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRAKEIVP 147
            :..:..|..::::       .||..||..:|..:|.|.:..|....|:|..|..:  :.|:|:||
 Worm   163 DAISITVAVVIVV-------TVGFVQEYRSEKTLEQLTKLVPPTCHVLRDGKEAM--MLARELVP 218

  Fly   148 GDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQDKKN---ILF 209
            ||:|.::.||:||:|:||...:|  |:||:|.||||:....|.|.::|...|...|.::   |.|
 Worm   219 GDIVLLNTGDRIPSDLRIAESFS--LQIDESSLTGETEPKHKETRSVPAASATGSDVEHLTCIAF 281

  Fly   210 SGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS----KVISVICVA 270
            .||.|.||:.||:||.|..::..|::...|...|..|||||:.:|:.|:|||    .||:||.:
 Worm   282 MGTLVCAGRGRGIVISTAANSQFGEVVKMMMGEESPKTPLQKSMDDLGKQLSIYSFGVIAVIFL- 345

  Fly   271 VWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS 335
                 ||.|..        :..:..|.|.|:|||||||||||.|:...||:|..||||:.|:|:.
 Worm   346 -----IGMFQG--------RNVVDMFTIGVSLAVAAIPEGLPIVVAVTLAIGVMRMAKRRAVVKK 397

  Fly   336 LPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEPIGEVF-LNG 399
            :|:||||||.:|||||||||||.|:|:...:   ...||..:     |:||..|...|.|. ..|
 Worm   398 MPAVETLGCVTVICSDKTGTLTKNEMTAQAI---ATPEGKLA-----EITGIGYSAEGGVVQYQG 454

  Fly   400 QRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFSVNKSGLDR 464
            :::....:.....:....::||::.|      :|.:.:|:.||.|::|||:|
 Worm   455 EQVHQWTHPEFARIIEAGLVCNNATI------EADKLIGQPTEGAIVVLAKK------------- 500

  Fly   465 RSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERC-THA 528
                 |....:.:::|:...:.||.|.|.|...|.......:     .|:|||.:.||::| |:.
 Worm   501 -----AQLEGVRSEYKRLREMPFSSDTKWMGVQCADAHGQNV-----YFIKGALDRVLDQCGTYY 555

  Fly   529 RVGTTKVPLTSALKAKILAL---TGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFYQYEVN 590
            .....:.......:..||.:   .||.|     ||.|.||..:|..                  :
 Worm   556 SSDNQRKQCDQYSRQHILEIGKELGQKG-----LRVLGLARGESMQ------------------S 597

  Fly   591 LTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTGKSYSG 655
            |.|:|::||:||||....|:|...:|:|:.|.:||||...||::|.:.:|:.:..:    ...||
 Worm   598 LMFLGMIGMMDPPRPGAADAISIVKASGVDVKLITGDAMETAQSIGQSLGILSSSD----SCLSG 658

  Fly   656 REFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAM 720
            ::.|.:|..:.:..:.:..:|.|..|:||.|||:.||::.|:.||||||||||.|||||:||:||
 Worm   659 QQVDQMSDHDLELVIRQVTVFYRASPRHKLKIVKALQALGEVVAMTGDGVNDAVALKKADIGVAM 723

  Fly   721 G-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLP 784
            | .||.|.|.||:|:|.||:||::.:|:|||:|||:|:..|:|:.:|:::..:..|..:......
 Worm   724 GVCGTDVCKEAADMILCDDDFSTMTAAIEEGKAIYHNITNFVRFQLSTSVAALSLIAASTMFKFD 788

  Fly   785 EALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVGAATV 849
            ..|..:|:||:|::.||.||.:||..|.|.||:.:.||...:.:::|.|....:|....:...|:
 Worm   789 NPLNAMQILWINIIMDGPPAQSLGVEPVDDDIIRQRPRNTKQPMLTGKLIADILASAAIIVVGTL 853

  Fly   850 GAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMN 914
            .      ||..|                      ...|.|:  .|...||..:..|..:|.||::
 Worm   854 S------VFYKE----------------------MSADNKV--TPRDTTMTFTCFVLFDMWNALS 888

  Fly   915 SLSENQSLITMPPWCNLWLIG-------SMALSFTL--HFVILYVDVLSTVFQVTPLSAEEWITV 970
            ..|..:.         :|.||       |:|:|.:|  ..:::|...|..:||...||..:.|.:
 Worm   889 CRSSRKM---------IWQIGLRRNRMFSLAVSASLICQLLVIYWAPLQHIFQTEALSLFDLIFL 944

  Fly   971 MKFSIPVVLLDETLKF 986
            ...:..|.:.:||.|:
 Worm   945 TTITSSVFIFNETRKY 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	317/991 (32%)
pmr-1	NP_001021862.1	P-type_ATPase_SPCA	115..959	CDD:319779	311/974 (32%)