DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERCA and Atp2c2

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_604457.1	Gene:	Atp2c2 / 171496	RGDID:	620647	Length:	944	Species:	Rattus norvegicus

Alignment Length:	1009	Identity:	339/1009 - (33%)
Similarity:	517/1009 - (51%)	Gaps:	149/1009 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFV 74
            |:....|..|.:.||:...:...:..:|.||..|:..:.:|:..|:||.:.|:.:||.::::|
  Rat    61 EELARTFHVDLDSGLSEFAVAQRRLVHGWNEFVTDNTEPVWKKYLDQFRNPLILLLLGSSVVS-- 123

  Fly    75 LALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQK 139
             .|.:|:|:..:      :.|.:||. ..||..||..:|.::|.|.:..|.....:|..|  ::.
  Rat   124 -VLTKEYEDAIS------IALAVLIV-VTVGFIQEYRSEKSLEELTKLVPPECNCLRDGK--LRH 178

  Fly   140 VRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQD- 203
            :.|:::||||:|.:|:||:||||||:|.:  |.|.:|:|..||| |.....||:   |.|...|
  Rat   179 MLARDLVPGDVVSLSMGDRIPADIRLTEV--TDLLVDESSFTGE-VEPCSKTDS---PLAGGGDL 237

  Fly   204 --KKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSKVISV 266
              ..|::|.||.|..||.:|||||||..:..|::...|...|..|||||:.:|:.|:||: |.|.
  Rat   238 STLSNVVFMGTLVQCGKGQGVVIGTGEQSQFGEVFKMMRAEETPKTPLQKSMDKLGKQLT-VFSF 301

  Fly   267 ICVAVWAINIGHFNDPAHGGSWIKG--AIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKK 329
            ..:.:..: :|          |::|  .:..|.|.|:|||||||||||.|:...|.||..|||||
  Rat   302 GIIGLLML-VG----------WVQGKPLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKK 355

  Fly   330 NAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEPIGE 394
            ..||:.||.||||||.:|||||||||||.|:|:.:::...|....        |::|..|...|.
  Rat   356 RVIVKKLPIVETLGCCNVICSDKTGTLTANEMTATQLVTSDGFHA--------EVSGIGYSGEGT 412

  Fly   395 VFLNGQRIKAADYDTLQELSTICI--------MCNDSAIDYNEFKQAFEKVGEATETALIVLAEK 451
            |.|...:      :.::|.|.:.:        :.|::.:..|..      :|:.||.||:|||.|
  Rat   413 VCLLPSK------EVIKEFSNVSVGKLVEAGCVANNAVVRKNAV------MGQPTEGALVVLAMK 465

  Fly   452 LNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKG 516
            :|..|:..|.:.                |||  :.||.::|.|:..|: ||..  ......|:||
  Rat   466 MNLGSIKDSYIR----------------KKE--IPFSSEQKWMAVRCS-LKNE--DEEDVYFMKG 509

  Fly   517 APEGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDS 581
            |.|.|:..|:....|...:|||...|:.......:.|    :|....||:|..|      :||
  Rat   510 AFEEVIHHCSTYNNGGIPLPLTPQQKSYCQQEEKKMG----SLGLRVLALASGP------ELG-- 562

  Fly   582 TKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDE 646
                    .|||:|:||::||||..|.:::.....:.:.|.::|||...||.||.|.||:.
  Rat   563 --------RLTFLGLVGIIDPPRAGVKEAVQALSESDVSVKMVTGDALETALAIGRTIGLC---- 615

  Fly   647 DTTGKSYSGREFDDLSPTEQKAAVARSR---LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDA 708
            |...|:.||.|.:.:   ||.|..||.|   :|.|..|:||.||::.||....|.|||||||||:
  Rat   616 DEKLKAMSGEEVEGM---EQDALAARVRQVSVFFRTSPKHKVKIIKALQESGAIVAMTGDGVNDS 677

  Fly   709 PALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEV 772
            .|||.|:|||||| :||.|:|.||:|:|.||:||:|:||||||:.|:.|:|.|:|:.:|::|..:
  Rat   678 VALKSADIGIAMGQTGTDVSKEAADMILVDDDFSAIMSAVEEGKGIFYNIKNFVRFQLSTSIAAL 742

  Fly   773 VSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRY 837
            ..|.|:....||..|..:|:||||::.||.||.:||..|.|.|.:::|||...:.:::..|..:.
  Rat   743 SLITLSTVCNLPNPLNAMQILWVNIIMDGPPAQSLGVEPVDRDALKRPPRSVKDTILNRALILKI 807

  Fly   838 MAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALS 902
            :.      :|.|......|:|..|.|:                        ...|.|...|||.:
  Rat   808 LM------SAAVILGGTLFIFWREIPE------------------------NRTSTPRTTTMAFT 842

  Fly   903 VLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEW 967
            ..|..::.||::..|:.:.:..:..:.|...:.|:..|......::|...|..|||...|||.:.
  Rat   843 CFVFFDLFNALSCRSQTKLIFEIGFFRNRMFLYSILGSLLGQLAVIYAPPLQKVFQTENLSALDL 907

  Fly   968 ITVMKFSIPVVLLDETL----KFVARKIADGESP 997
            :.:...:..|.:|.|.|    ||.:|..||...|
  Rat   908 LLLTGLASSVFILSELLKLCEKFCSRAKADQMLP 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	335/999 (34%)
Atp2c2	NP_604457.1	Interaction with ORAI1. /evidence=ECO:0000250\|UniProtKB:O75185	69..93		6/23 (26%)
Atp2c2	NP_604457.1	P-type_ATPase_SPCA	83..925	CDD:319779	327/969 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730