Protein Alignment SERCA and Atp2c1

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: XP_038936657.1
• Gene: Atp2c1 / 170699
• RGDID: 621311
• Length: 965
• Species: Rattus norvegicus
• Alignment Length: 1000
• Identity: 341/1000 - (34%)
• Similarity: 514/1000 - (51%)
• Gaps: 149/1000 - (14%)

  Fly     9 VEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISF 73
            |.:.......|.:.||...::...:..:|.||....|.:.:|:..:.||.:.|:.:||.:|:||.
  Rat    65 VSEVAGLLQADLQNGLNKSEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISV 129

  Fly    74 VLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQ 138
            ::..|::       .|...|.:||::..|.|   ||..:|.::|.|.:..|.....||:.|  ::
  Rat   130 LMRQFDD-------AVSITVAILIVVTVAFV---QEYRSEKSLEELSKLVPPECHCVREGK--LE 182

  Fly   139 KVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQD 203
            ...|:::||||.|.:||||::|||:|:  ..:..|.||:|.||||:....|.|  .|.|.|.|.|
  Rat   183 HTLARDLVPGDTVCLSVGDRVPADLRL--FEAVDLSIDESSLTGETTPCSKVT--APQPAATNGD 243

  Fly   204 ---KKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS---- 261
               :.||.|.||.|..|||:|:|||||.::..|::...|...|..|||||:.:|..|:|||
  Rat   244 LASRSNIAFMGTLVRCGKAKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSF 308

  Fly   262 KVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM 326
            .:|.:|.:..|.:.              |..:..|.|:|:|||||||||||.|:|..||||..||
  Rat   309 GIIGIIMLVGWLLG--------------KDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRM 359

  Fly   327 AKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEP 391
            .||.|||:.||.||||||.:|||||||||||.|:|:|:.:...|.        |..|:||..|..
  Rat   360 VKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHILTSDG--------LHAEVTGVGYNQ 416

  Fly   392 IGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFS 456
            .|||.::|..:.......:..:.....:|||:.|..|..      :|:.||.|||.||.|:
  Rat   417 FGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTL------MGKPTEGALIALAMKM---- 471

  Fly   457 VNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCT-PLKASRLGTGPKL-FVKGAPE 519
                |||          .::..:.::....||.::|.|:..|. ..:..|    |:: |:|||.|
  Rat   472 ----GLD----------GLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDR----PEICFMKGAYE 518

  Fly   520 GVLERCTHARVGTTKVPLTSALKAKILALTGQY---------GTGRDTLRCLALAVADSPMKPDE 575
            .|::.||           |...|.:.||||.|.         ..|...||.|||  |..|
  Rat   519 QVIKYCT-----------TYNSKGQTLALTQQQRDLYQQEKAQMGSAGLRVLAL--ASGP----- 565

  Fly   576 MDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIG 640
             |||          .|||:|:||::||||..|.:::....|:|:.:.:||||::.||.||..|:|
  Rat   566 -DLG----------QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAIAIASRLG 619

  Fly   641 VFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGV 705
            ::::    |.:|.||.|.|.:........|.:..:|.|..|:||.||::.||....:.|||||||
  Rat   620 LYSK----TSQSVSGEEVDTMEVQHLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGV 680

  Fly   706 NDAPALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNI 769
            |||.|||.|:||:||| :||.|.|.||:|:|.||:|.:|:||:|||:.||||:|.|:|:.:|::|
  Rat   681 NDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSI 745

  Fly   770 GEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLF 834
            ..:..|.|...:..|..|..:|:||:|::.||.||.:||..|.|.|::.||||...:.:::..|.
  Rat   746 AALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLI 810

  Fly   835 FRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTM 899
            .:.:.....:...|:      |||         |:            |.:  |..|  .|...||
  Rat   811 LKILVSSIIIVCGTL------FVF---------WR------------ELR--DNVI--TPRDTTM 844

  Fly   900 ALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSA 964
            ..:..|..:|.||::|.|:.:|:..:....|.....::..|.....:::|...|..|||...||.
  Rat   845 TFTCFVFFDMFNALSSRSQTKSVFEIGLCSNKMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSI 909

  Fly   965 EEWITVMKFSIPVVLLDETLKFVAR 989
            .:.:.::..:..|.::.|.:|.|.|
  Rat   910 LDLLFLLGLTSSVCIVSEIIKKVER 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	340/998 (34%)
Atp2c1	XP_038936657.1	P-type_ATPase_SPCA	88..930	CDD:319779	334/971 (34%)