Protein Alignment SERCA and Atp2a2

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_001103610.1
• Gene: Atp2a2 / 11938
• MGIID: 88110
• Length: 1044
• Species: Mus musculus
• Alignment Length: 989
• Identity: 719/989 - (72%)
• Similarity: 837/989 - (84%)
• Gaps: 1/989 - (0%)

  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65
            ||:.|:||||:.|..||.:...||:|:|:|..::::|.||||.||||::.:||:|||:||||:||
Mouse     1 MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL 65

  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130
            ||||.||||||.|||.|||.||||||.||||||:|||:||||||||||:|||||||||||||||.
Mouse    66 LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVY 130

  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195
            |||:..:|:::||:|||||:||::||||:|||||:|.|.|||||:|||||||||||||||||.:|
Mouse   131 RQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVP 195

  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260
            |||||||||||:||||||:|||||.|||:.||::|.|||||.||..||:.:||||||||||||||
Mouse   196 DPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQL 260

  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |||||:||:|||.|||||||||.||||||:|||||||||||||||||||||||||||||||||||
Mouse   261 SKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390
            ||||||||||||||||||||||||||||||||||||||.||||.|||||:..|..||.:|||||.
Mouse   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFSITGSTYA 390

  Fly   391 PIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455
            |||||..:.:.:|...||.|.||:|||.:|||||:||||.|..:|||||||||||..|.||:|.|
Mouse   391 PIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVF 455

  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEG 520
            .....||.:...|.||...|:...||||||||||||||||.||||.|.||.... |:||||||||
Mouse   456 DTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMS-KMFVKGAPEG 519

  Fly   521 VLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFY 585
            |::||||.|||:||||:|..:|.||:::..::|:|.|||||||||..|:|:|.:||.|.||..|.
Mouse   520 VIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLKREEMHLEDSANFI 584

  Fly   586 QYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTG 650
            :||.||||||.||||||||.||..|:..||.||||||:||||||.||.|||||||:|.:|||.|.
Mouse   585 KYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTS 649

  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715
            |:::|||||:|||:.|:.|...:|.|:||||.|||||||||||.:||:|||||||||||||||:|
Mouse   650 KAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSE 714

  Fly   716 IGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAA 780
            |||||||||||||:|:||||||||||:||:|||||||||||||||||||||||:||||.||||||
Mouse   715 IGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA 779

  Fly   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVG 845
            ||.||||||||||||||||||||||||||||||||||.||||...|.||||||||||:|||.|||
Mouse   780 LGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVG 844

  Fly   846 AATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEML 910
            |||||||||||:.:|.||::|::||:|.|.|.....:|.||||.||..|:.|||||||||||||.
Mouse   845 AATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFDGVDCAIFESPYPMTMALSVLVTIEMC 909

  Fly   911 NAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSI 975
            ||:|||||||||:.||||.|:||:||:.||.:|||:||||:.|..:||:|||:..:|:.|:|.|:
Mouse   910 NALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISL 974

  Fly   976 PVVLLDETLKFVAR 989
            ||:|:|||||||||
Mouse   975 PVILMDETLKFVAR 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	715/983 (73%)
Atp2a2	NP_001103610.1	P-type_ATPase_SERCA	5..988	CDD:319778	715/983 (73%)
		Interaction with HAX1. /evidence=ECO:0000250	575..594		11/18 (61%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	787..807		19/19 (100%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000269|PubMed:23395171	788..1044		142/201 (71%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	931..942		6/10 (60%)