DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERCA and Atp2a1

DIOPT Version :9

Sequence 1:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster
Sequence 2:	NP_031530.2	Gene:	Atp2a1 / 11937	MGIID:	105058	Length:	994	Species:	Mus musculus

Alignment Length:	994	Identity:	719/994 - (72%)
Similarity:	836/994 - (84%)	Gaps:	0/994 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65
            ||..|||:.|:.|::||.....|||.||:|.:.:||||||||.|||||:|:||:|||:||||:||
Mouse     1 MEAAHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRIL 65

  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130
            ||||.||||||.|||.|||.||||||.||||||||||:||||||||||:|||||||||||||||.
Mouse    66 LLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVY 130

  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195
            |.|:..:|:::|::|||||:|||:||||:||||||..|.|||||:|||||||||||||||||.:|
Mouse   131 RADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTDPVP 195

  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260
            |||||||||||:||||||:|||||.|:|..||:||.|||||.:|:.||:.|||||||||||||||
Mouse   196 DPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQL 260

  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |||||:||||||.|||||||||.|||||.:|||||||||||||||||||||||||||||||||||
Mouse   261 SKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390
            ||||||||||||||||||||||||||||||||||||||.:|||.|||:|:..|..||.:|||||.
Mouse   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDVCSLNEFSITGSTYA 390

  Fly   391 PIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455
            |.|||..|.:.::|..||.|.||:|||.:||||::|:||.|..:|||||||||||..|.||:|.|
Mouse   391 PEGEVLKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVF 455

  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEG 520
            :.....|.:...|.||...|....||||||||||||||||.||:|.|:||...|.|:||||||||
Mouse   456 NTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEG 520

  Fly   521 VLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFY 585
            |::||.:.|||||:||||..:|.||:::..::|||||||||||||..|:|.|.:||.|.||.||.
Mouse   521 VIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSAKFM 585

  Fly   586 QYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTG 650
            :||::|||||||||||||||||..||..||.||||||:||||||.||.|||||||:|:|:|:.|.
Mouse   586 EYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENEEVTD 650

  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715
            ::|:|||||||...||:.|..|:..|:||||.|||||||:|||.:||:|||||||||||||||||
Mouse   651 RAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAE 715

  Fly   716 IGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAA 780
            |||||||||||||:|:||||||||||:||:|||||||||||||||||||||||:||||.||||||
Mouse   716 IGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA 780

  Fly   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVG 845
            |||||||||||||||||||||||||||||||||||||::|||...|.||||||||||||||.|||
Mouse   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVG 845

  Fly   846 AATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEML 910
            |||||||||||:::::||.:||.||||.:.|.....||.|:||::|..|..|||||||||||||.
Mouse   846 AATVGAAAWWFLYAEDGPHVSYHQLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVTIEMC 910

  Fly   911 NAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSI 975
            ||:|||||||||:.||||.|:||:||:.||.:|||:|||||.|..:|::..|...:|:.|:|.|:
Mouse   911 NALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLKISL 975

  Fly   976 PVVLLDETLKFVARKIADG 994
            ||:.|||.|||:||...:|
Mouse   976 PVIGLDELLKFIARNYLEG 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	714/983 (73%)
Atp2a1	NP_031530.2	P-type_ATPase_SERCA	5..989	CDD:319778	714/983 (73%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	788..808		19/19 (100%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	932..943		6/10 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I1004
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7635
Inparanoid	1	1.050	1448	1.000	Inparanoid score	I115
Isobase	1	0.950	-	0	Normalized mean entropy	S832
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm43847
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	LDO	PTHR42861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3239
SonicParanoid	1	1.000	-	-		X745
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.820