DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NUP98 and Neos

DIOPT Version :9

Sequence 1:	NP_001352054.1	Gene:	NUP98 / 4928	HGNCID:	8068	Length:	1831	Species:	Homo sapiens
Sequence 2:	NP_001261502.1	Gene:	Neos / 38795	FlyBaseID:	FBgn0024542	Length:	371	Species:	Drosophila melanogaster

Alignment Length:	242	Identity:	48/242 - (19%)
Similarity:	90/242 - (37%)	Gaps:	90/242 - (37%)

- Green bases have known domain annotations that are detailed below.

Human  1229 YQTPLELKLKHSTVHVDELCP----------------------LIVP------NLGVAVIHDYAD 1265
            |...:|.:||:|::.||.|.|                      |:.|      ::.|.:::.
  Fly   143 YAEYIEERLKNSSLRVDVLFPNEDVLLGKVLANISSRGCLYAVLVTPQHEEHNSITVNILYG--- 204

Human  1266 WVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDS------------QLNEPREYIQILERRR 1318
             |.....::|....:       ||....:...|:.|:            |...|:|...:|||
  Fly   205 -VPAEHRNMPLEDAI-------TLISTDFRLKKQRDAVVLPPSTSIHKGQRRHPQEMQGLLER-- 259

Human  1319 AFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKR-------ISEACSLAQ-QSGDHRLAL- 1374
                         :.:...||.  |..|.:..||.|:|       :.||.:||: ::.|..:.|
  Fly   260 -------------LADNHPLTA--SQYEVILKYLEGEREEQLKREVGEANALAKLKAPDPEIELQ 309

Human  1375 --LLSQFVGSQSVRELLTMQLVDWHQLQADSF--IQDERLRIFALLA 1417
              :|| .:...:|.::.:       :|...:|  ::::| |:..|||
  Fly   310 KKILS-IMNKPAVTDVTS-------ELMYPTFEAVKEDR-RLMELLA 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NUP98	NP_001352054.1	Nucleoporin_FG	40..149	CDD:316182
		Nucleoporin_FG	239..332	CDD:316182
		Herpes_BLLF1	<243..666	CDD:330317
		Nucleoporin_FG	363..463	CDD:316182
		Nucleoporin2	723..862	CDD:309287
		Nup96	1348..1637	CDD:314912	20/83 (24%)
Neos	NP_001261502.1	U2AF_lg	<19..149	CDD:273727	1/5 (20%)
Neos	NP_001261502.1	RRM_SF	20..78	CDD:388407
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900