DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyp3c3 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	151/522 - (28%)
Similarity:	262/522 - (50%)	Gaps:	64/522 - (12%)

- Green bases have known domain annotations that are detailed below.

Zfish     2 IDLSSLSVTWTLVFLVITLLYMYGVWPHGFFKKLGIPGPRPWPFFGTF-----LSYTKGFFNFDM 61
            :|.:.|.:|..|.||:..|.|.:..|     :..|||..||...||.|     :.|:: ......
  Fly     1 MDFTLLLLTSLLSFLLGYLRYRFTYW-----ELRGIPQLRPHFLFGHFFRLQSVHYSE-LLQETY 59

Zfish    62 ECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDER 126
            :..:...||.|.|....|:.:|.||:::|.::::: ::.|.:||..:.|   ||...:..::.|.
  Fly    60 DAFRGSAKVAGTYVFLRPMAVVLDLDLVKAVLIRD-FNNFVDRRSFHGD---PLTANLFNLQGEE 120

Zfish   127 WKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKRDHEQ--PVKIKEVVAPYSLDVVTSSSF 189
            |:.:|..|||.||||::|.:|....|.|.:......:....|  .:::.:::|.|:.||:.|.:|
  Fly   121 WRNLRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAF 185

Zfish   190 SVDIDSINNPDDPF-------VTNIKNFLKFSLFSPLILFLTLFPSIANLLGKMGISVFSRSIMN 247
            ..:..|:..|...|       ..|....:::.:|.     :|...|:|.|  .:.:.:....|..
  Fly   186 GTECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFK-----MTYLSSLAKL--GLPVRILHPDITK 243

Zfish   248 FFYTALRK-IKDEHKDSNGRVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEILSQSFIFILGG 311
            ||...:|: ::...:::..|.||:.|::          |...::..||||..::.:|:|:|.:.|
  Fly   244 FFNRIVRETVELRERENIRRNDFMDLLL----------DLRRQENGKGLTMEQMAAQAFVFFVAG 298

Zfish   312 YETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFPLDTPISYDALMKMDYLEMSINESMRLLPTAP 376
            :||:|:.:|:.|..||.|.|..:||..||:.:......::|:|:|:|.||:.:|.|::|..|...
  Fly   299 FETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALS 363

Zfish   377 RLERVCKKTVEL------NGITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFLQY 435
            .|.|:..:..|:      :.:.:.|.|.|.||...::.||:::..|.|||||||:|:...|....
  Fly   364 SLTRLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPT 428

Zfish   436 AFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLELTPVFQPKVPITLKLTPRK 500
            ||:.||.|||||||:||..|.||:.::.||:.|..      .:|        |..|..||:|  |
  Fly   429 AFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRF------SLP--------PGSPTQLKVT--K 477

Zfish   501 RN 502
            ||
  Fly   478 RN 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	135/478 (28%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	140/486 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820