Protein Alignment NUP88 and mbo

DIOPT Version :10

• Sequence 1: NP_001307582.1
• Gene: NUP88 / 4927
• HGNCID: 8067
• Length: 757
• Species: Homo sapiens
• Sequence 2: NP_524330.2
• Gene: mbo / 41562
• FlyBaseID: FBgn0026207
• Length: 702
• Species: Drosophila melanogaster
• Alignment Length: 772
• Identity: 210/772 - (27%)
• Similarity: 353/772 - (45%)
• Gaps: 129/772 - (16%)

Human    23 VFLRLREGLKNQSPTEAEKPASSSLPSSPPPQLLTRNVVFGLGGELFLWDGEDSSFLVVRLRGPS 87
            :|.::|.||                    |....|:|::......||.|..:||..||...|.
  Fly    14 LFAKIRNGL--------------------PVVQRTQNLLDCKDDLLFAWHAKDSCLLVRNWRS-- 56

Human    88 GGGEEPALS-----QYQRLLCINPPLFEIYQVLLSPTQHHVALIGIKGLMVLELPKRWGKNSEFE 147
                  :|:     |:|.|:..:....|:.:||.|.....|||.|.:|::::|||:|||.:..::
  Fly    57 ------SLAAKVNIQFQTLIPSSLVSLEVDRVLASNEGSLVALSGPRGVVIMELPRRWGPDGYYK 115

Human   148 GGKSTVNCSTTPVAERFFTSSTSLTLKHAAWYPSEILDPHVVLLTSDNVIRIYS---LREPQTPT 209
            .||..:.|.|..:..:.|..:..|.::...|:|..:.|..:::|.::|.||:|:   ||......
  Fly   116 DGKPVITCRTFGLDTQLFLKNPHLEVRQVRWHPHSVSDSTLLVLLNNNTIRVYNHSKLRHVWQVG 180

Human   210 NVIILSEAEEESLVLNKGRAYTASLGETAVAFDFGPLAAVP-------------------KTLFG 255
            ..::.|.|...          ....||.||.||..| ||.|                   |||..
  Fly   181 PPVLRSGANNS----------LCDFGELAVDFDIAP-AAKPRVTEPETAGNNETTLDKSNKTLVA 234

Human   256 QNG--KDEVVAYPLYILYENGETFLTYISLLHSPGNIGKLLGPLPMHPAAEDNYGYDACAVLCLP 318
            ...  |.|.:.:|:.:|.|||.   .||.:........:|.||:.:.|.|.||||.::||::.:|
  Fly   235 AKSLPKQERIEWPMVVLRENGN---IYILMTGVDSENTRLQGPVTITPQAHDNYGLESCALMIIP 296

Human   319 CVPNILVIATESGMLYHCVVLEGEEEDDHTSEKSWDSRIDLIPSLY---VFECVELELALKL-AS 379
            .:|..:|||..:|.|:|.:::|.|..:...:|.  |..:.:.|:.|   |.|.|||||.:.. |:
  Fly   297 SLPPTIVIAESNGKLHHALLMEAEATEHSFNEV--DDSVLIEPAEYVVHVLETVELELGISAPAT 359

Human   380 GEDDPFDSDFSCPVKLHRDPKCPSRYHCTHEAGVHSVGLTWIHKLHKFLGSDEEDKDSLQELSTE 444
            |::..     :||:.|.||.....||...|.||:|:|.:::|.:|.::|.| |.|:|.| ||:..
  Fly   360 GKEGG-----NCPIYLKRDLINELRYFAYHNAGLHAVTVSFIAELQRYLES-ESDEDRL-ELAVS 417

Human   445 QKCFVEHILCTKPLPCRQPAPIRGFWIVPDILGPTMIC----ITSTYECLIWPLLSTVHPASPPL 505
            ..  .|:|||||.........:.|..::....|..::.    :.|....:...||.|.:...|
  Fly   418 AS--AEYILCTKFDSSETVNAVFGLALLQIPAGIVLLLGSGQVISLKLVIDAQLLVTPNENKP-- 478

Human   506 LCTREDVEVAESPLRVLAETPDSFEKHIRSILQRSVANPAFLNCFTQLRKIKVETLFLRASEKDI 570
                .|.||::.      |:...|...|:|:|||||..|..                   ::|..
  Fly   479 ----VDSEVSQQ------ESGPPFVDTIKSLLQRSVNQPIL-------------------ADKLS 514

Human   571 APPPEECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMA 635
            :|..:|..:||::|.:|.||||:.:.||.:....|.:..:..:|::||:::....:||:.:.|.|
  Fly   515 SPSAQESFELLNQAIEVLREQYLKRHDLVRAAFTRHINQIQLKKEQQLQEIQDLEQERELISERA 579

Human   636 ERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTM 700
            .:||:::||....||.::.:...|:...::.||....:||:..:|:..:....:.|...::  |.
  Fly   580 HKLAERFEEISYNQELLVRKCNALMQRANASLPNSVIAEREFSQEVIRLNKVTQSLAAGLE--TA 642

Human   701 KKDYQQQKMEKVLS---LPKPTIILSAYQRKCIQSILKE-EGEHIREM--VKQINDI 751
            ||.:.:|:.....|   |.|....|...|.:.|..||.: .||..|::  ||:||.|
  Fly   643 KKTFNKQRYHIAQSQEDLKKNAYELPEKQHRTITEILTQLTGEIDRQITDVKRINKI 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP88	NP_001307582.1	Nup88	14..756	CDD:462975	210/772 (27%)
mbo	NP_524330.2	Nup88	4..701	CDD:462975	210/772 (27%)