DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pp1-87B and PPP3CB

DIOPT Version :9

Sequence 1:NP_524937.1 Gene:Pp1-87B / 49260 FlyBaseID:FBgn0004103 Length:302 Species:Drosophila melanogaster
Sequence 2:NP_001135825.1 Gene:PPP3CB / 5532 HGNCID:9315 Length:525 Species:Homo sapiens


Alignment Length:299 Identity:113/299 - (37%)
Similarity:169/299 - (56%) Gaps:40/299 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 KNVQLSEGEI----------RGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGG 78
            ||..:.||.:          .|..:..||     ..::|:|||:.:|||||||::||::|||.||
Human    56 KNHLVKEGRVDEEIALRIINEGAAILRRE-----KTMIEVEAPITVCGDIHGQFFDLMKLFEVGG 115

  Fly    79 FPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYS 143
            .|..:.|||||||||||..|:|.:..|...||.|....|||||||||..:...:.|..|||.:||
Human   116 SPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS 180

  Fly   144 IKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPD 208
            .::::...:.|:.||:||:::::..|.||||||::.:::.|||:.|..:.|..|.:||||||||.
Human   181 ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPS 245

  Fly   209 KDTMGWGEND----------RGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRM--- 260
            :|   :|...          ||.|:.:....|.:|||.:....|.|||:..:.||..:.|..   
Human   246 ED---FGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTG 307

  Fly   261 ---LVTLFSAPNYCGEFDNAGAMMSVDDTLM------CS 290
               |:|:||||||...::|..|::..::.:|      ||
Human   308 FPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCS 346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pp1-87BNP_524937.1 MPP_PP1_PPKL 6..296 CDD:277359 113/299 (38%)
PPP3CBNP_001135825.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
MPP_PP2B 50..354 CDD:277361 113/299 (38%)
Catalytic. /evidence=ECO:0000305 65..356 109/290 (38%)
SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209 316..320 3/3 (100%)
Calcineurin B binding. /evidence=ECO:0000269|PubMed:26794871 357..379
Calmodulin-binding. /evidence=ECO:0000269|PubMed:26794871 402..416
Autoinhibitory segment. /evidence=ECO:0000269|PubMed:26794871 417..424
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:26794871 475..497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0639
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53795
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.