DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and MCM6

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_011314.2	Gene:	MCM6 / 852673	SGDID:	S000003169	Length:	1017	Species:	Saccharomyces cerevisiae

Alignment Length:	885	Identity:	200/885 - (22%)
Similarity:	333/885 - (37%)	Gaps:	295/885 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 RLYFLREKYEEGNELATR-----IMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIK-------- 167
            ::|.|...|.:...|:.|     .||:...|.|              |.|....|::
Yeast   144 KIYDLNTIYIDYQHLSMRENGALAMAISEQYYR--------------FLPFLQKGLRRVVRKYAP 194

  Fly   168 -----SDAQLKEV------------------WPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDC 209
                 ||: ||..                  ..||..|.........||.::|..::
Yeast   195 ELLNTSDS-LKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGNGTSAMATRSI-------- 250

  Fly   210 NDSTTAMVSTPEQYVLPTPRVRKI--YARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSY 272
               ||:  ::|||    |.||.:|  :..|    .|..|..|...::.:|.||.|.|:...|...
Yeast   251 ---TTS--TSPEQ----TERVFQISFFNLP----TVHRIRDIRSEKIGSLLSISGTVTRTSEVRP 302

  Fly   273 SLTWQAFRCSRCQMEIAMRQRGTFQPRPYQCKRSEC---------VARDEFVPLRSSPYTRLSIR 328
            .|...:|.|..|:..:...::......|..|....|         |.|..|:..
Yeast   303 ELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDW----------- 356

  Fly   329 QIIRVEESSLNLVHDFET-SMPAEMDVELRHDLVDAVR-------VGQEVVVTGILKLQELG-DD 384
            |.:|::|::    ::..| |||..:||.||.|.|:..:       .|.|:||..:.:|...| ..
Yeast   357 QKVRIQENA----NEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKP 417

  Fly   385 TTTGDTS---------NQMQPYLKAVSIR-------------------------DASSIKREF-- 413
            ::|.||.         |.....|:::.:|                         ||:|..||.
Yeast   418 SSTLDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRETEL 482

  Fly   414 --------------SERDLEAIVMINA----EPNSFK----------LLVQSIAPEVYGHELPKA 450
                          :|||.|  |.:|:    |.|..|          .||:||||.|:|||..|.
Yeast   483 QMAANLQANNVYQDNERDQE--VFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKK 545

  Fly   451 ACLLSLLGGKGAETEA-------INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQL 508
            ..||.:|||....|..       ||:.:||||...|::.|:.....|.|..:.|||  |.||  .
Yeast   546 GILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGK--ASSA--A 606

  Fly   509 GVTFA-GRNKR----VLQAGSLMMASGGGHCTLDDVDKL-ASKQAVLLQCLQSEEVNLPLAGAFA 567
            |:|.| .|::.    .::||:||:|. .|.|.:|:.||: .|.|..:.:.::.:.:::..||..|
Yeast   607 GLTAAVVRDEEGGDYTIEAGALMLAD-NGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHA 670

  Fly   568 SFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSER-DMSLTAHVRALH 631
            :..|:.|::|.|||..|:|:....|..|:|::..::..|.|.:::||..:|: |..|.:|:..||
Yeast   671 TLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLH 735

  Fly   632 AGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPE 696
            .                                 |.|:.|:
Yeast   736 M---------------------------------KRDEAIE------------------------ 743

  Fly   697 EGDLDLLPPI---LIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDV------SSQI 752
                   ||.   .:::::.||| ...|:|.::|.:.::..:.||:     .:|.      |.:|
Yeast   744 -------PPFSAEQLRRYIKYAR-TFKPILTKEARSYLVEKYKELR-----KDDAQGFSRSSYRI 795

  Fly   753 GAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKEGSSRQGTRGGGGAGGGAG 817
            ...||.::|.||:|.||.:....::|..:.:...||.:||.:..:.:....:
Yeast   796 TVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDVDDVEMDE------------- 847

  Fly   818 KSAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGILT 857
                  .|..:..:..||.|.     ::..:.||.:|::|
Yeast   848 ------EFDNIESQSHAASGN-----NDDNDDGTGSGVIT 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	22/118 (19%)
		MCM	243..792	CDD:214631	158/653 (24%)
		P-loop_NTPase	468..606	CDD:304359	45/143 (31%)
MCM6	NP_011314.2	MCM_N	112..205	CDD:405270	15/75 (20%)
		MCM	272..836	CDD:214631	159/655 (24%)
		MCM6_C	900..1007	CDD:408078
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810