DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and MCM7

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_009761.4	Gene:	MCM7 / 852501	SGDID:	S000000406	Length:	845	Species:	Saccharomyces cerevisiae

Alignment Length:	848	Identity:	190/848 - (22%)
Similarity:	343/848 - (40%)	Gaps:	206/848 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 LYFLREKYEEGNELATRIMAVEAYYQRNPHTFDFVMIR--DRGF-FPLCAAGIKSDAQLKEVWPS 178
            |.:..||:.:|.:....:.|:    |:|.:.|..:..|  |... .|......|.|.
Yeast    86 LQYQNEKFLQGTQADDLVSAI----QQNANHFTELFCRAIDNNMPLPTKEIDYKDDV-------- 138

  Fly   179 LSEDIREHPLRTLGTLSLAMHTVVVNHQLD--------CNDSTTAMVSTPEQYVLPTPRVRKIYA 235
            |...:.:..||....||...:.:...:.:|        .||:...:|. .|..:.|....|:.:.
Yeast   139 LDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDALREVVE-DETELFPPNLTRRYFL 202

  Fly   236 RPDDFVPVE-----------------SIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSR 283
            .   |.|:.                 |:..|....:..|.::||.::.|.:...::...|:.|.:
Yeast   203 Y---FKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQ 264

  Fly   284 CQMEIAMRQRG-TFQPRPYQCKRSECVARDE----FVPLRSSPYTRLSIRQIIRVEESS--LNLV 341
            |..|:...... ||.|.. :|...||.....    |:..|:|   :.|..|..:::|.|  :.:.
Yeast   265 CGYEVFQEVNSRTFTPLS-ECTSEECSQNQTKGQLFMSTRAS---KFSAFQECKIQELSQQVPVG 325

  Fly   342 HDFETSMPAEMDVELRHDLVDAVRVGQEVVVTGI--------LKLQELGDDTTTGDTSNQMQPYL 398
            |     :|..:::.:...||.::..|..|.||||        .|..:.|..|.|         ||
Yeast   326 H-----IPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKALKAGLLTET---------YL 376

  Fly   399 KAVSIRD------ASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLL 457
            :|..:|.      :.|:..:..||.:|.|    ...:.:..|.:|||||:||:...|.|.||.|:
Yeast   377 EAQFVRQHKKKFASFSLTSDVEERVMELI----TSGDVYNRLAKSIAPEIYGNLDVKKALLLLLV 437

  Fly   458 G------GKGAETEA-INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFA-- 513
            |      |.|.:... |||.|:||||:.|:::|::..:|:.||.:.:||    .:..:|:|.|
Yeast   438 GGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGK----GSSGVGLTAAVM 498

  Fly   514 ---GRNKRVLQAGSLMMASGGGHCTLDDVDKL-ASKQAVLLQCLQSEEVNLPLAGAFASFPAQPS 574
               ..::.:|:.|:|::|. .|.|.:|:.||: .|.:..:.:.::.:.:::..||...:..|:.|
Yeast   499 KDPVTDEMILEGGALVLAD-NGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTS 562

  Fly   575 VIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPS-ERDMSLTAHVRALHAGARKRA 638
            ::|.|||..|:|:.....|.|||:..:||..|.:::::||.|| :.|..|..||..:|
Yeast   563 ILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVH------- 620

  Fly   639 RIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLL 703
                                                                  :..::.|||..
Yeast   621 ------------------------------------------------------MHNKQPDLDFT 631

  Fly   704 P--PILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAGQ-----LLAII 761
            |  |..::::::||:.: .||::|..::.|::.::.|:.....:.|  |:...||     ||.||
Yeast   632 PVEPSKMREYIAYAKTK-RPVMSEAVNDYVVQAYIRLRQDSKREMD--SKFSFGQATPRTLLGII 693

  Fly   762 HLSQARARLDLSHVVSPQHVRDVIALL---TESITQTSLKEGSSRQGTRGGGGAGGGAGKSAQLR 823
            .||||.|:|.|:.:|....|.:.:.|:   .||:.|.:.|.......|                .
Yeast   694 RLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQETNKSKEDESPT----------------T 742

  Fly   824 NFLELTKRRSAALGRRIFEFDELKEIGTRAGILTGFSQL------VEMANLGGYLLMKGANMYEV 882
            ....:.|:.....|:....::.:    .:...|.||:.|      .|.:.|..:.|:...|..:.
Yeast   743 KIFTIIKKMLQETGKNTLSYENI----VKTVRLRGFTMLQLSNCIQEYSYLNVWHLINEGNTLKF 803

  Fly   883 VPD 885
            |.|
Yeast   804 VDD 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	18/85 (21%)
		MCM	243..792	CDD:214631	147/610 (24%)
		P-loop_NTPase	468..606	CDD:304359	43/143 (30%)
MCM7	NP_009761.4	MCM_N	52..>123	CDD:405270	9/40 (23%)
MCM7	NP_009761.4	MCM	223..724	CDD:214631	146/591 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810