DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and MCM2

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_009530.1	Gene:	MCM2 / 852258	SGDID:	S000000119	Length:	868	Species:	Saccharomyces cerevisiae

Alignment Length:	688	Identity:	159/688 - (23%)
Similarity:	292/688 - (42%)	Gaps:	158/688 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 LRTLGTLSLAMHTVVVNHQLD-----------CND------STTAMVSTPEQYVLPT-PRVR-KI 233
            :||||.::.....|...|..:           |.:      ...||.:|...|  |. .|:. :|
Yeast   231 IRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHY--PDYARIHSEI 293

  Fly   234 YARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRC-------------Q 285
            :.|..||..:.|:..:..|.:.:|..:.|.|:........|.:..|.|.:|             :
Yeast   294 HVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEE 358

  Fly   286 MEIAM----RQRGTFQPRPYQCKRSECVARD-EFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFE 345
            :.|:.    :.:|     |::....:.|.|: :.|.|:.:|.|....|
Yeast   359 IRISFCTNCKSKG-----PFRVNGEKTVYRNYQRVTLQEAPGTVPPGR----------------- 401

  Fly   346 TSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKAVSIRDASSIK 410
              :|...:|.|..||||..:.|:||.||||.|....|:       .|....:....:|.:|:|||
Yeast   402 --LPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGN-------LNAKNGFPVFATIIEANSIK 457

  Fly   411 R------EFSERDLEAIVMINAEPNSFK----------LLVQSIAPEVYGHELPKAACLLSLLG- 458
            |      ...|..|:.......|...|:          .::.|:||.:|||...|.|...||.|
Yeast   458 RREGNTANEGEEGLDVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGG 522

  Fly   459 ------GKGAETEAINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFAGRNK 517
                  ||.:....|||||:||||..|::||:...:.|.|....:|    |.|..:|:|.:.|..
Yeast   523 VPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATG----QGASAVGLTASVRKD 583

  Fly   518 RV-----LQAGSLMMASGGGHCTLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVI 576
            .:     |:.|:|::|. .|.|.:|:.||:..:....: :.::.:.:::..||...:..|:.|:|
Yeast   584 PITKEWTLEGGALVLAD-KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSII 647

  Fly   577 ACANPQRGQYDEGRYLLQNINISPSLLREFHLVYI---LLDKPSERDMS---LTAHVRALHAGAR 635
            |.|||..|:|:....|.||::::..:|..|.::.:   |:|:.::..::   :.:|||: |
Yeast   648 AAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRS-H---- 707

  Fly   636 KRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYD-----LDKRLEVL- 694
                                      |...:|.:..:.:::.:|.::|..|     |:.|...|
Yeast   708 --------------------------PENDEDREGEELKNNGESAIEQGEDEINEQLNARQRRLQ 746

  Fly   695 ---PEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDVSS---QIG 753
               .:|.::..:|..|:.|::.|||.::.|.|::...:.|.|.:.:|:     .|.:|:   .|.
Yeast   747 RQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLR-----RESISTGSFPIT 806

  Fly   754 AGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
            ...|.:|:.::::.|::.||..||...:...|.::.:|
Yeast   807 VRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDS 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	4/11 (36%)
		MCM	243..792	CDD:214631	142/614 (23%)
		P-loop_NTPase	468..606	CDD:304359	43/143 (30%)
MCM2	NP_009530.1	MCM2_N	49..193	CDD:403724
		MCM_N	209..298	CDD:405270	15/68 (22%)
		MCM	302..846	CDD:214631	142/615 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810