DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and MCM5

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_013376.1	Gene:	MCM5 / 850980	SGDID:	S000004264	Length:	775	Species:	Saccharomyces cerevisiae

Alignment Length:	813	Identity:	171/813 - (21%)
Similarity:	333/813 - (40%)	Gaps:	158/813 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 SFLRPENYAAPEDGLQVQSIAVDNP----RAYSGWRLYF-LREKYEEGNELATRIMAVEAYYQRN 144
            ||.|||.|:||.  ||.:|...|:.    :::..:.|.| |..::...::|...|:........|
Yeast     2 SFDRPEIYSAPV--LQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVN 64

  Fly   145 -PHTFDFVMIRDRGFFPLCAAGIKSDAQLKEVWPSLSEDIRE-HPLRTLGTLSLAMHTVVVNHQL 207
             .|...:                     .::::..||::..: .||.......:|....:::...
Yeast    65 MEHLIGY---------------------NEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQ 108

  Fly   208 DCN----DSTTAMVSTPEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVG 268
            ..|    |.....:.|....:...|..:.|.....:.:|:..::.   ..|..:..:.|.:.:..
Yeast   109 SANNNDKDPENTSMDTDSLLLNSLPTFQLILNSNANQIPLRDLDS---EHVSKIVRLSGIIISTS 170

  Fly   269 EPSYSLTWQAFRCSRCQMEIAMRQR------GTFQPRPYQC---------KRSECVARDEFVPLR 318
            ..|...|:.:..|..|:...::...      |.....|..|         ..:|....||.....
Yeast   171 VLSSRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKN 235

  Fly   319 SSPYTRLSIRQIIR-VEESSLNLVHDFET----SMPAEMDVELRHDLVDAVRVGQEVVVTGILKL 378
            ..|...:.|.:..: :::..|.|....|.    .||..:.:.....|.:.|..|..|.:.||..:
Yeast   236 CGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI 300

  Fly   379 QELGDDTTTGDTSNQ--------MQPYLKAVSIR---DASSIKRE---FSERDLEAIVMINAEPN 429
            ....:...:|.:...        ..||:|.:.|:   :.|||...   |:|.:.|..:.::..|.
Yeast   301 YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPK 365

  Fly   430 SFKLLVQSIAPEVYGHELPKAACLLSLLGGK------GAETEA-INVLLVGDPGIGKTKILQSCA 487
            .:::|..||||.::|:|..|.|.:..|:||.      |..... |||||:||||..|:::|:...
Yeast   366 LYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVE 430

  Fly   488 QIAERGAHVSGKRGAQSAQQLGVTFAGRNKRV-----LQAGSLMMASGGGHCTLDDVDKLASKQA 547
            :::....:.||| |:.:|   |:|.:.:...:     |:.|::::|.||..| :|:.||:..:..
Yeast   431 KVSPIAVYTSGK-GSSAA---GLTASVQRDPMTREFYLEGGAMVLADGGVVC-IDEFDKMRDEDR 490

  Fly   548 VLL-QCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYI 611
            |.: :.::.:.:::..||......::.||:|.|||..|:||:.:....||:...::|..|.:::|
Yeast   491 VAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFI 555

  Fly   612 LLDKPS-ERDMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTED 675
            :.|..: |||:|:..||..:|.|...        |::.:..::..|:|:.
Yeast   556 VKDDHNEERDISIANHVINIHTGNAN--------AMQNQQEENGSEISIE--------------- 597

  Fly   676 DNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKG 740
                                           .:|::::|.|.:..|.|:..|:..:...|:.::.
Yeast   598 -------------------------------KMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRK 631

  Fly   741 SCNLDEDVSSQ-----IGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKEG 800
            ...::|..|::     |...||.|||.::::.|:|:||.:...:||.:.|.|.     |.|..:.
Yeast   632 QLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLF-----QASTMDA 691

  Fly   801 SSRQGTRGGGGAGGGAGKS-AQLRNFLELTKRR 832
            :|:...   ||....:|.| :::|.|.:..|||
Yeast   692 ASQDPI---GGLNQASGTSLSEIRRFEQELKRR 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	12/85 (14%)
		MCM	243..792	CDD:214631	129/601 (21%)
		P-loop_NTPase	468..606	CDD:304359	41/143 (29%)
MCM5	NP_013376.1	MCM_N	29..>101	CDD:405270	12/92 (13%)
MCM5	NP_013376.1	MCM	144..689	CDD:214631	132/611 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810