DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and MCM8

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001319512.1	Gene:	MCM8 / 820123	AraportID:	AT3G09660	Length:	801	Species:	Arabidopsis thaliana

Alignment Length:	753	Identity:	220/753 - (29%)
Similarity:	368/753 - (48%)	Gaps:	111/753 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 DIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYAR----PDDFVP 242
            ::.::|...:..::.|:|.|:.: |.:.|:....|               ||..|    |:..:
plant    96 NLEDNPKGVIPCMNAAVHKVLFD-QWETNEFENVM---------------KINVRLHNYPESSI- 143

  Fly   243 VESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMR-QRGTFQPRPYQCKRS 306
              |::.:..:.:..|.::.|.|..|......:|..||.|.:|:..|... ..|.|.| |.:|...
plant   144 --SLKNLRAAYIGKLVTVHGTVVKVSTVKPLVTQMAFDCGKCKTGITREFTDGKFSP-PLKCDSH 205

  Fly   307 ECVARDEFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELRHDLVDAVRVGQEVV 371
            .|.:: .|.|:|||..| :.. |.|||:|......|: |..:|..::.||..||||....|..|.
plant   206 GCKSK-TFTPIRSSAQT-IDF-QKIRVQELQKPEDHE-EGRVPRTVECELMEDLVDICIPGDVVT 266

  Fly   372 VTGIL----KLQELGDDTTTGDTSNQMQPYL--KAVSIR------------DASSIKR------- 411
            ||||:    ...::|...:  .|.||...||  :|||::            |:||..:
plant   267 VTGIIGVINNYMDIGGGKS--KTKNQGFYYLFIEAVSVKNTKRQSAFENSEDSSSSAQTADVGDL 329

  Fly   412 -EFSERDLEAIVMINAE--PNSFKLLVQSIAPEVYGHELPKAACLLSLLGG---------KGAET 464
             .||:||||.||....|  .::|:.::.|:.|.:||||:.||...|||.||         |....
plant   330 YSFSQRDLEFIVKFKEEYGSDTFRRILHSVCPSIYGHEIVKAGITLSLFGGVRKHSMDRNKVPVR 394

  Fly   465 EAINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFA-----GRNKRVLQAGS 524
            ..|:|::|||||:||:::||:.|.|:.||.:|.|    .:..:.|:|.|     ..|....:||:
plant   395 GDIHVIIVGDPGLGKSQLLQAAAAISPRGIYVCG----NATTRAGLTVAVVKDSMTNDYAFEAGA 455

  Fly   525 LMMASGGGHCTLDDVDKLASKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEG 589
            :::|. ||.|.:|:.||:.::...||:.::.:.|::..||..||..|:.||||.|||..|.|:..
plant   456 MVLAD-GGLCCIDEFDKMTTEHQALLEAMEQQCVSVAKAGLVASLSARTSVIAAANPVGGHYNRA 519

  Fly   590 RYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALHAGARKRARIAARYALKPKMSDS 653
            :.:.:|:.:|.:||..|.||:||||||.| .|..::.|:.:||:.:.:.:....::  ||..:.|
plant   520 KTVNENLKMSAALLSRFDLVFILLDKPDELLDKQVSEHIMSLHSASGETSPALKKF--KPVNAAS 582

  Fly   654 MCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQE 718
            ......|:.|.|           |..:.:...|.:|       :.|...:|..|::|::||||..
plant   583 QNAGYANMHAEG-----------NSLLSRLRLDSEK-------DDDFSPVPGQLLRKYISYARNF 629

  Fly   719 LNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRD 783
            :||.:::||...:.:::|:|:.. |...| |:.|.|.||.:::.|:|||||:||...::.|...|
plant   630 VNPKMSKDAGEIIQKFYLKLRDH-NTSAD-STPITARQLESLVRLAQARARVDLREEITVQDAMD 692

  Fly   784 VIALLTESITQTSLKEGSSRQGTRG--GGGAGGGAGKSAQLRNFLELTKRRSAALGRRIFEFDEL 846
            |:.::.||:....:.|       .|  ..|..||..:..:.:.||....::|....:..|...|:
plant   693 VVEIMKESLYDKLIDE-------HGVVDFGRSGGMSQQKEAKRFLSALDKQSELQQKDCFSVSEM 750

  Fly   847 KEIGTRAGI-LTGFSQLVEMANLGGYLLMKGANMYEVV 883
            ..:..|.|: :......:|..|:.||||.||...|:|:
plant   751 YSLADRIGLRVPDIDTFLENLNIAGYLLKKGPKTYQVL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	2/17 (12%)
		MCM	243..792	CDD:214631	186/592 (31%)
		P-loop_NTPase	468..606	CDD:304359	50/142 (35%)
MCM8	NP_001319512.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55021
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	1	1.000	-	-		FOG0001226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104142
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5321
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790