DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and MCM4

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_179236.3	Gene:	MCM4 / 816142	AraportID:	AT2G16440	Length:	847	Species:	Arabidopsis thaliana

Alignment Length:	948	Identity:	213/948 - (22%)
Similarity:	378/948 - (39%)	Gaps:	235/948 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PTLSRGGAPSRFVRGRGRGGGAYRPYFYFRRNGRVIPAGGNRQPNQGEPGAPDAPSVPPATRQPR 67
            ||.....|.|:...|.|.|||                .||.     |:||.|.:...|
plant    67 PTSRPSAARSKGRNGHGGGGG----------------GGGG-----GDPGTPMSTDEP------- 103

  Fly    68 GWSRTAGKRGRNAHLDCSFLRPENYAAPEDG--------LQVQSIAVDNPRAYSGWRLYFLREKY 124
                                .|.:....|||        :...:|:|.:.::.....:...||..
plant   104 --------------------LPSSDDGEEDGGDDTTPTFVWGTNISVQDVKSAIEMFVKHFREAR 148

  Fly   125 EEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDA-QLKEVWPSLSEDIREHPL 188
            |..::|..     |..|          |:..|....:....|..|| .:.:..|.|...:..:||
plant   149 ENSDDLFR-----EGKY----------MVSIRKVIEIEGEWIDVDAFDVFDYDPDLYNKMVRYPL 198

  Fly   189 RTLGTLSLAMHTVV--VNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYARPDDFVPVESIEGISH 251
            ..|....:.:..:|  :|...             |::|    :||....|..     .|:..::.
plant   199 EVLAIFDIVLMDIVSTINRLF-------------EKHV----QVRIFNLRTS-----TSMRNLNP 241

  Fly   252 SRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQ--MEIAMRQRGTFQPRPYQCKRSECVARDEF 314
            |.::.:.|::|.:.........:....|||..|.  .:..:..||... .|..|.:.||:.::..
plant   242 SDIEKMISLKGMIIRSSSIIPEIREAVFRCLVCGYFSDPIIVDRGKIS-EPPTCLKQECMTKNSM 305

  Fly   315 VPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQ 379
            ..:.:.  .|.:.:||:|::|:...:.   |...|..:.:.|...|||..:.|..:.||||.:..
plant   306 TLVHNR--CRFADKQIVRLQETPDEIP---EGGTPHTVSLLLHDKLVDNGKPGDRIEVTGIYRAM 365

  Fly   380 ELGDDTTTGDTSNQMQPYLKAVSIRDAS--------------SIKR-----EFSERDLEAIVMIN 425
            .:..........:..:.|:..:.|:.||              |::|     |..|..|.....::
plant   366 TVRVGPAHRTVKSVFKTYIDCLHIKKASKLRMSAEDPMDVDNSLRRVDEDVELDEEKLRKFQELS 430

  Fly   426 AEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGG------KGAETEA-INVLLVGDPGIGKTKIL 483
            .:|:.::.|.:|:||.::..:..|...|..|.||      .||.... ||:|||||||..|:::|
plant   431 KQPDIYERLSRSLAPNIWELDDVKKGLLCQLFGGNALNLASGANFRGDINILLVGDPGTSKSQLL 495

  Fly   484 QSCAQIAERGAHVSGKRGAQSAQQLGVT-FAGRN----KRVLQAGSLMMASGGGHCTLDDVDKLA 543
            |...:::.||.:.|| ||:.:   :|:| :..::    :.||::|:|:: |..|.|.:|:.||::
plant   496 QYIHKLSPRGIYTSG-RGSSA---VGLTAYVAKDPETGETVLESGALVL-SDRGICCIDEFDKMS 555

  Fly   544 -SKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFH 607
             |.:::|.:.::.:.|::..||..||..|:.||:|||||...:|:....:::||::.|:||..|.
plant   556 DSARSMLHEVMEQQTVSIAKAGIIASLNARTSVLACANPSGSRYNPRLSVIENIHLPPTLLSRFD 620

  Fly   608 LVYILLDKPSER-DMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTI 671
            |:|::||||.|: |..|..|:.|||.   :.|..|...|:                    |..|:
plant   621 LIYLILDKPDEQTDRRLAKHIVALHF---ENAESAQEEAI--------------------DITTL 662

  Fly   672 KTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFL 736
            .|                                     ::||||:.::|.|:::|:..:.|.::
plant   663 TT-------------------------------------YVSYARKNIHPKLSDEAAEELTRGYV 690

  Fly   737 ELKGSCNLDEDVSSQIGA--GQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKE 799
            ||:.:..........|.|  .|:.::|.||:|.||:..|..|....|.:...||..::.|::...
plant   691 ELRKAGKFAGSSKKVITATPRQIESLIRLSEALARMRFSEWVEKHDVDEAFRLLRVAMQQSATDH 755

  Fly   800 GSSRQGTRGGGGAGGGAGKSAQLRNFLELTKRRSAALGR--------RIFE-FDELKEIG----- 850
            .:   ||........|...|.::|.....:..|..||.:        |:.| .:|||:.|
plant   756 AT---GTIDMDLINTGVSASERMRRDTFASSIRDIALEKMQIGGSSMRLSELLEELKKHGGNINT 817

  Fly   851 ------TRAGILTGFSQLVEMANLGGYLLMKGANMYEV 882
                  .|..:.|..|:        |:|:.:|..:..|
plant   818 EIHLHDVRKAVATLASE--------GFLVAEGDRIKRV 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	16/83 (19%)
		MCM	243..792	CDD:214631	146/585 (25%)
		P-loop_NTPase	468..606	CDD:304359	50/143 (35%)
MCM4	NP_179236.3	PHA03307	<2..>76	CDD:223039	3/8 (38%)
		MCM_N	140..231	CDD:405270	22/122 (18%)
		MCM	232..747	CDD:214631	146/590 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820