DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and MCM5

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_178812.1	Gene:	MCM5 / 815415	AraportID:	AT2G07690	Length:	727	Species:	Arabidopsis thaliana

Alignment Length:	842	Identity:	181/842 - (21%)
Similarity:	311/842 - (36%)	Gaps:	252/842 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 SGWRLYFLREKYEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDAQLKEVWP 177
            |||         :||          ..||...|.            ||  .||..:......|..
plant     2 SGW---------DEG----------AVYYSDQPQ------------FP--EAGDAATISPHAVLT 33

  Fly   178 SLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVSTPEQYV------------LPTPRV 230
            ...|.||...:                 :.:|.....|::..|::.|            ||:
plant    34 KFKEFIRNFEI-----------------EQNCFPYREALLDNPKRLVVHLEDLLSFDSDLPS--- 78

  Fly   231 RKIYARPDDFVPV---------------ESIEG-------------ISHSRVD------------ 255
             .|.:.|.|::||               |:.||             :..||.|
plant    79 -LIRSAPADYLPVFEKAAGEVLTGLKMREANEGGVMEEPLTRDVQILLTSREDPVSMRLLGAQYI 142

  Fly   256 -TLFSIRGFVSNVGEPSYSLTWQAFRCSRCQ--MEIAMRQ--RGTFQPRPYQCKR-----SECVA 310
             .|..|.|............|:....|..|:  .|:..|.  .|...||  .|..     .|...
plant   143 SKLVKISGISIAASRVKAKATYVFLVCKNCKKTREVPCRPGLGGAIVPR--SCDNIPQPGEEPCP 205

  Fly   311 RDEF--VPLRSSPYTRLSIRQIIRVEESSLNLVHDFET-SMPAEMDVELRHDLVDAVRVGQEVVV 372
            .|.:  ||.||. |..   :|.::::|:.    .|..| .:|..|.:.:...||..:..|..:.|
plant   206 LDPWMVVPDRSQ-YVD---QQTLKLQENP----EDVPTGELPRNMLLSVDRHLVQTIVPGTRLTV 262

  Fly   373 TGILKLQELGDDTTTGDTSNQ-------MQPYLKAVSIRDASSIK----REFSERDLEAIVMINA 426
            .||..:.:      ...:||.       .|||::.|.:.|.:...    ..|:..:.|.......
plant   263 MGIYSIFQ------ASSSSNSHKGAVAIRQPYIRVVGLEDTNEASSRGPANFTPDEEEEFKKFAD 321

  Fly   427 EPNSFKLLVQSIAPEVYGHELPK--AACLLSLLGGK------GAETEA-INVLLVGDPGIGKTKI 482
            ..:.:|.:...|||.::|||..|  ||||  |.||.      |.:... |||||:|||...|::.
plant   322 SQDVYKNICTKIAPSIFGHEDVKRAAACL--LFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQF 384

  Fly   483 LQSCAQIAERGAHVSGKRGAQSAQQLGVTF-----AGRNKRVLQAGSLMMASGGGHCTLDDVDKL 542
            |:...:.|....:.||| |:.:|   |:|.     :...:..|:.|::::|.||..| :|:.||:
plant   385 LKFVEKTAPIAVYTSGK-GSSAA---GLTASVIRDSSTREFYLEGGAMVLADGGVVC-IDEFDKM 444

  Fly   543 ASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREF 606
            ..:..|.: :.::.:.:::..||......::.||:|.|||..|:||:.:....||::..::|..|
plant   445 RPEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRF 509

  Fly   607 HLVYILLD-KPSERDMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDT 670
            .|::|:.| :...:|..:.:|:..:||.|.|.:                             |:.
plant   510 DLIFIVKDIRKYSQDKEIASHIIRVHASANKFS-----------------------------DEN 545

  Fly   671 IKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYF 735
            ..:::||                             .:|:::.|.|...:|.|::||:..:.|.:
plant   546 TDSKEDN-----------------------------WLKRYIQYCRARCHPRLSKDAAENLQRKY 581

  Fly   736 LELKGSCNLD---------EDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTES 791
            :.::    :|         |.....|...||.||:.||::.|::.|||..:|..| |....|.::
plant   582 VTIR----MDMKRRAHETGEAAPIPITVRQLEAIVRLSESLAKMRLSHEATPDDV-DKAFKLFDT 641

  Fly   792 ITQTSLKEGSSRQGTRGGGGAGGGAGKSAQLRNFLELTKRRSAALGRRIFE---FDELKEIG 850
            .|..:.:.|.::|...        .|:.|......|...:|...:|.|:.|   .::|..:|
plant   642 STMDAARSGINQQINI--------TGEMANEIKQAETQIKRRMGIGARLSERRLIEDLARMG 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	13/82 (16%)
		MCM	243..792	CDD:214631	143/637 (22%)
		P-loop_NTPase	468..606	CDD:304359	41/143 (29%)
MCM5	NP_178812.1	MCM_N	35..127	CDD:379644	17/112 (15%)
MCM5	NP_178812.1	MCM	131..644	CDD:214631	136/598 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820