DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and Mcm9

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_038955210.1	Gene:	Mcm9 / 499437	RGDID:	1560557	Length:	1128	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	145/691 - (20%)
Similarity:	252/691 - (36%)	Gaps:	217/691 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 TVVVNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYARPDDFVPVESIEGIS-----HSRVDTL-- 257
            ||..|..|...||.....:......||.|                  ||:|     |:|:..|
  Rat    59 TVFPNEVLTVFDSALRRSALAVLQSLPEP------------------EGLSMKQNLHARISGLPV 105

  Fly   258 ------------------FSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMR----QRGTFQPRP 300
                              .|:.|.|............:.:.|::|:....::    |..||. ||
  Rat   106 CPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKYVFTVKADFEQYYTFS-RP 169

  Fly   301 YQCKRSECVARDEFV--------PLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELR 357
            ..|..|:.....:|.        |.|...|..:.|::  :|:..|:.       |:|..|.|.|.
  Rat   170 SSCPSSDTCDSSKFTCLSDLSASPARCRDYQEIKIQE--QVQRLSVG-------SIPRSMKVILE 225

  Fly   358 HDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKAVSIRDASSIKREFSERDLEAIV 422
            .||||:.:.|.::.:.|::              ..:.:|:.:.:.......:|..:        |
  Rat   226 DDLVDSCKSGDDLTIYGVV--------------MQRWKPFQRDMRCEVEIVLKANY--------V 268

  Fly   423 MINAEPNSFKL--------------------------LVQSIAPEVYGHELPKAACLLSLLGGKG 461
            .:|.|.:|..:                          ::.|:.|:|:|..|.|.|..:.|.||.
  Rat   269 QVNNEQSSGMVMDEDARKEFEDFWEHYKSDPFAGRNEILASLCPQVFGMYLVKLAVAMVLAGGI- 332

  Fly   462 AETEAI--------NVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFAGRNKR 518
            ..|:|.        ::|||||||.||::.|:..|:|..|....:|         :|.|.||....
  Rat   333 QRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTG---------IGSTSAGLTVT 388

  Fly   519 V--------LQAGSLMMASGGGHCTLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPS 574
            .        |:||:|::|. .|.|.:|:.:.|.......: :.::.:.:::..||.......:.:
  Rat   389 AVKDSGEWNLEAGALVLAD-AGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTT 452

  Fly   575 VIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSERDMSLTAHVRALHAGARKRAR 639
            ::|..|| :||||....:..||.:...||..|.|:.:|||..:| |..                |
  Rat   453 ILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTRNE-DWD----------------R 499

  Fly   640 IAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLP 704
            |.:.:.|:.|...|..|   |:                       :.::|
  Rat   500 IISSFILENKGYPSKSE---NL-----------------------WSMEK--------------- 523

  Fly   705 PILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAGQLLAIIHLSQARAR 769
               :|.:....| .|:|.|::.::..:|||:...:.|   |...:::.....|.::|.|::|.||
  Rat   524 ---MKTYFCLIR-NLHPTLSDVSNQVLLRYYQMQRQS---DSRNAARTTIRLLESLIRLAEAHAR 581

  Fly   770 LDLSHVVSPQHVRDVIALLTESITQTSLKEGSSRQGTRGGG 810
            |.....|:          |.::||..|:.|.|.:.|...||
  Rat   582 LMFRSTVT----------LEDAITVVSVMESSMQGGALLGG 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	145/691 (21%)
		MCM	243..792	CDD:214631	128/628 (20%)
		P-loop_NTPase	468..606	CDD:304359	40/146 (27%)
Mcm9	XP_038955210.1	MCM_OB	116..243	CDD:407328	29/136 (21%)
		MCM9	305..603	CDD:350666	90/384 (23%)
		PHA03307	667..>1014	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920