DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rec and mcm4

DIOPT Version :9

Sequence 1:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001005655.1	Gene:	mcm4 / 448137	XenbaseID:	XB-GENE-1011481	Length:	863	Species:	Xenopus tropicalis

Alignment Length:	902	Identity:	196/902 - (21%)
Similarity:	350/902 - (38%)	Gaps:	238/902 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NPTLSRGGAPSRFVRGRGRGGGAYRPYFYFRRNGRVI---PAGGNRQPNQGEPG----APDAPSV 59
            :||    ..|||....||||.....|:      |..:   |:...|..:....|    .|.:||
Frog     3 SPT----STPSRRRNKRGRGSNPPTPH------GEEVQSPPSQRRRTEDSTSIGELLPMPTSPS- 56

  Fly    60 PPATRQPRG----WSRTAGKRGRNAHLDCSFLRPENYAAPEDGLQVQSIAVDNPRAYSGWRLYFL 120
             ...:.|.|    :|..|..|......:.....|..|..|...::      ..||  ||.|....
Frog    57 -GDLQSPSGQELMFSSPAPSRHSALQSELDLSSPLTYGTPSSRVE------GTPR--SGIRGTPA 112

  Fly   121 REKYEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDAQLKE---VW------ 176
            |::.:.|:  |.::..|:.:..:                |.....:.|:..|.:   :|
Frog   113 RQRPDLGS--ARKVKQVDLHSDQ----------------PAAEELVTSEQSLGQKLVIWGTDVNV 159

  Fly   177 PSLSEDIREHPLRTLGTLSLAMHTV-----------------VVNH---QLDCN-------DSTT 214
            .:..|..:....|.:..|:.....|                 ||..   .:||:       |...
Frog   160 ATCKEKFQRFVQRFIDPLAKEEENVGLDLNEPIYMQRLEEINVVGEPFLNVDCDHLRSFDQDLYR 224

  Fly   215 AMVSTPEQYVLPTPRV----------------RKIYARPDDFVPVESIEGISHSRVDTLFSIRGF 263
            .:|..|:: |:||..:                .:|..||.:.:...::..::...:|.|.:|.|.
Frog   225 QLVCYPQE-VIPTFDMAANEIFFERYPDSILEHQIQVRPYNALKTRNMRSLNPEDIDQLITISGM 288

  Fly   264 VSNVGEPSYSLTWQAFRCSRC----QMEIAMRQRGTFQPRPYQCKRSECVARDEFVPLRSSPYTR 324
            |....:....:....|:|..|    ::||   .||... .|..||..........:..||    .
Frog   289 VIRTSQIIPEMQEAFFKCQVCAFTTRVEI---DRGRIS-EPSVCKHCNTTHSMALIHNRS----M 345

  Fly   325 LSIRQIIRVEESSLNLVHDFETSMPAEMDVEL-----RHDLVDAVRVGQEVVVTGILKLQELGDD 384
            .|.:|:|:::||        ...|||......     .:||||.|:.|..|.||||.:...:..:
Frog   346 FSDKQMIKLQES--------PEDMPAGQTPHTTILYGHNDLVDKVQPGDRVNVTGIYRAVPIRVN 402

  Fly   385 TTTGDTSNQMQPYLKAVSIR----------DASSIKREFSERDLEAIVMINAEPNSFKLLVQSIA 439
            ....:..:..:.::..:..|          |..:.::.|:|..:..:..:.|:|:.::.|..::|
Frog   403 PRVRNVKSVYKTHIDVIHYRKTDAKRLHGIDEDTEQKMFTEERVAMLKELAAKPDIYERLASALA 467

  Fly   440 PEVYGHELPKAACLLSLLG---------GKGAETEAINVLLVGDPGIGKTKILQSCAQIAERGAH 495
            |.:|.||..|...||.|.|         |:|.....:|:||.||||..|:::||....:..||.:
Frog   468 PSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQY 532

  Fly   496 VSGKRGAQSAQQLGVTF-----AGRNKRVLQAGSLMMASGGGHCTLDDVDKL-ASKQAVLLQCLQ 554
            .|||    .:..:|:|.     ....:.|||.|:|:: |..|.|.:|:.||: .|.::||.:.::
Frog   533 TSGK----GSSAVGLTAYVMKDPETRQLVLQTGALVL-SDNGICCIDEFDKMNESTRSVLHEVME 592

  Fly   555 SEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSER 619
            .:.:::..||......|:.||:|.|||...|::..:..::||.:..:||..|.|::::||...|.
Frog   593 QQTLSIAKAGIICQLNARTSVLAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDET 657

  Fly   620 -DMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQ 683
             |..|..|:.||:
Frog   658 YDRRLAHHLVALY---------------------------------------------------- 670

  Fly   684 DYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDV 748
             |..::::    :|..||:   .::|.:::|||..:||.|.|:||.|::..:::::
Frog   671 -YQSEEQM----KEEHLDM---AVLKDYIAYARTYVNPRLGEEASQALIEAYVDMR--------- 718

  Fly   749 SSQIGAG---------QLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTS 796
              :||:|         ||.::|.||:|.|::..|..|....|.:...|..|::.|::
Frog   719 --KIGSGRGMVSAYPRQLESLIRLSEAHAKVRFSSKVETIDVEEAKRLHREALKQSA 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	11/91 (12%)
		MCM	243..792	CDD:214631	140/592 (24%)
		P-loop_NTPase	468..606	CDD:304359	45/143 (31%)
mcm4	NP_001005655.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121		32/139 (23%)
		PHA03307	<3..>122	CDD:223039	32/140 (23%)
		MCM_N	166..264	CDD:379644	16/98 (16%)
		MCM	267..770	CDD:214631	140/594 (24%)
		Arginine finger	642..645		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920