Protein Alignment rec and MCM6

DIOPT Version :10

• Sequence 1: NP_732072.1
• Gene: rec / 49241
• FlyBaseID: FBgn0003227
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_005906.2
• Gene: MCM6 / 4175
• HGNCID: 6949
• Length: 821
• Species: Homo sapiens
• Alignment Length: 845
• Identity: 195/845 - (23%)
• Similarity: 330/845 - (39%)
• Gaps: 192/845 - (22%)

  Fly    93 AAPEDGLQVQSIAVDNPRAYSGWRLY--FLREKYEEGNELATRIMAVEAYY-QRNPHTFDFVMIR 154
            ||.|.|...|.:.|.:..|....:|:  ||.|......|:....:|.|... :||.....||
Human     5 AAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFV--- 66

  Fly   155 DRGFFPLCAAGIKSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVST 219
                            .|::....||..|:|...|....|..|:.|.|.:.:
Human    67 ----------------DLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRK------------- 102

  Fly   220 PEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRC 284
                  ..|..:..|....|......|..::.||:..|..|.|.|.........|....|.|..|
Human   103 ------EIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDC 161

  Fly   285 QMEIAMRQRGTFQPRPYQCKRSECVARDEFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMP 349
            |..|...::.....:|..|:...|..|..|  |..:..:|....|.:|::|:...|...   |:|
Human   162 QTVIRDVEQQFKYTQPNICRNPVCANRRRF--LLDTNKSRFVDFQKVRIQETQAELPRG---SIP 221

  Fly   350 AEMDVELRHDLVDAVRVGQE-------VVVTGILKLQELGDDTTTGDTSNQMQPY-------LKA 400
            ..::|.||.:.|::.:.|.:       :||..:.||...|....|....:.:..|       |:|
Human   222 RSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRA 286

  Fly   401 VSIRD------------------------------ASSIKREFSERDLEAIVMINAEPNSFKLLV 435
            :.:||                              |.|||.:.:.::.|.:..::.:.|.:..|.
Human   287 LGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLC 351

  Fly   436 QSIAPEVYGHELPKAACLLSLLG------GKGAETEA-INVLLVGDPGIGKTKILQSCAQIAERG 493
            .|:.|.::|::..|...||.|.|      |:|..... |||.:||||...|::.|:...:.:.|.
Human   352 TSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRA 416

  Fly   494 AHVSGKRGAQSAQQLGVTFA-----GRNKRVLQAGSLMMASGGGHCTLDDVDKL-ASKQAVLLQC 552
            .:.|||  |.||  .|:|.|     ..::.|::||:||:|. .|.|.:|:.||: ...|..:.:.
Human   417 VYTSGK--ASSA--AGLTAAVVRDEESHEFVIEAGALMLAD-NGVCCIDEFDKMDVRDQVAIHEA 476

  Fly   553 LQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPS 617
            ::.:.:::..||..|:..|:.|::|.|||..|.||..:.|.||||:|..::..|.|.:||:|:.:
Human   477 MEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECN 541

  Fly   618 E-RDMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIM 681
            | .|.::...:..||:                                       :.|:..|.:
Human   542 EVTDYAIARRIVDLHS---------------------------------------RIEESIDRV- 566

  Fly   682 QQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDE 746
               |.||.                  |:::|.:||| ..|.:::::.:.::..:..|:.......
Human   567 ---YSLDD------------------IRRYLLFARQ-FKPKISKESEDFIVEQYKHLRQRDGSGV 609

  Fly   747 DVSS-QIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSL-------KEGSSR 803
            ..|| :|...||.::|.||:|.||:.....|.|:||::...||.:||.:...       :|....
Human   610 TKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQM 674

  Fly   804 QGTRGGGGAGGGAGKSAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGILTGFSQLVEMANL 868
            :...|.||..|.|...|.:.             |...:..|..:|...:|.:..|||:...::||
Human   675 EVDEGAGGINGHADSPAPVN-------------GINGYNEDINQESAPKASLRLGFSEYCRISNL 726

  Fly   869  868
            Human   727  726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rec	NP_732072.1	Mcm2	177..799	CDD:440854	160/687 (23%)
		MCM8	433..791	CDD:350665	98/372 (26%)
		MCM8_WHD	819..883	CDD:439328	10/50 (20%)
MCM6	NP_005906.2	MCM_N	27..116	CDD:464206	23/126 (18%)
		MCM	119..657	CDD:475121	147/609 (24%)
		Arginine finger	528..531		0/2 (0%)
		MCM6_C	713..817	CDD:465688	5/14 (36%)