DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rec and MCM6

DIOPT Version :9

Sequence 1:NP_001262615.1 Gene:rec / 49241 FlyBaseID:FBgn0003227 Length:885 Species:Drosophila melanogaster
Sequence 2:NP_005906.2 Gene:MCM6 / 4175 HGNCID:6949 Length:821 Species:Homo sapiens


Alignment Length:845 Identity:195/845 - (23%)
Similarity:330/845 - (39%) Gaps:192/845 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 AAPEDGLQVQSIAVDNPRAYSGWRLY--FLREKYEEGNELATRIMAVEAYY-QRNPHTFDFVMIR 154
            ||.|.|...|.:.|.:..|....:|:  ||.|......|:....:|.|... :||.....||   
Human     5 AAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFV--- 66

  Fly   155 DRGFFPLCAAGIKSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVST 219
                            .|::....||..|:|...|....|..|:.|.|.:.:             
Human    67 ----------------DLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRK------------- 102

  Fly   220 PEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRC 284
                  ..|..:..|....|......|..::.||:..|..|.|.|.........|....|.|..|
Human   103 ------EIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDC 161

  Fly   285 QMEIAMRQRGTFQPRPYQCKRSECVARDEFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMP 349
            |..|...::.....:|..|:...|..|..|  |..:..:|....|.:|::|:...|...   |:|
Human   162 QTVIRDVEQQFKYTQPNICRNPVCANRRRF--LLDTNKSRFVDFQKVRIQETQAELPRG---SIP 221

  Fly   350 AEMDVELRHDLVDAVRVGQE-------VVVTGILKLQELGDDTTTGDTSNQMQPY-------LKA 400
            ..::|.||.:.|::.:.|.:       :||..:.||...|....|....:.:..|       |:|
Human   222 RSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRA 286

  Fly   401 VSIRD------------------------------ASSIKREFSERDLEAIVMINAEPNSFKLLV 435
            :.:||                              |.|||.:.:.::.|.:..::.:.|.:..|.
Human   287 LGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLC 351

  Fly   436 QSIAPEVYGHELPKAACLLSLLG------GKGAETEA-INVLLVGDPGIGKTKILQSCAQIAERG 493
            .|:.|.::|::..|...||.|.|      |:|..... |||.:||||...|::.|:...:.:.|.
Human   352 TSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRA 416

  Fly   494 AHVSGKRGAQSAQQLGVTFA-----GRNKRVLQAGSLMMASGGGHCTLDDVDKL-ASKQAVLLQC 552
            .:.|||  |.||  .|:|.|     ..::.|::||:||:|. .|.|.:|:.||: ...|..:.:.
Human   417 VYTSGK--ASSA--AGLTAAVVRDEESHEFVIEAGALMLAD-NGVCCIDEFDKMDVRDQVAIHEA 476

  Fly   553 LQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPS 617
            ::.:.:::..||..|:..|:.|::|.|||..|.||..:.|.||||:|..::..|.|.:||:|:.:
Human   477 MEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECN 541

  Fly   618 E-RDMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIM 681
            | .|.::...:..||:                                       :.|:..|.: 
Human   542 EVTDYAIARRIVDLHS---------------------------------------RIEESIDRV- 566

  Fly   682 QQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDE 746
               |.||.                  |:::|.:||| ..|.:::::.:.::..:..|:.......
Human   567 ---YSLDD------------------IRRYLLFARQ-FKPKISKESEDFIVEQYKHLRQRDGSGV 609

  Fly   747 DVSS-QIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSL-------KEGSSR 803
            ..|| :|...||.::|.||:|.||:.....|.|:||::...||.:||.:...       :|....
Human   610 TKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQM 674

  Fly   804 QGTRGGGGAGGGAGKSAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGILTGFSQLVEMANL 868
            :...|.||..|.|...|.:.             |...:..|..:|...:|.:..|||:...::||
Human   675 EVDEGAGGINGHADSPAPVN-------------GINGYNEDINQESAPKASLRLGFSEYCRISNL 726

  Fly   869  868
            Human   727  726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
recNP_001262615.1 RNR_PFL <117..200 CDD:299130 19/85 (22%)
MCM 243..792 CDD:214631 146/607 (24%)
P-loop_NTPase 468..606 CDD:304359 48/143 (34%)
MCM6NP_005906.2 MCM_N 27..114 CDD:405270 23/124 (19%)
MCM 119..657 CDD:214631 147/609 (24%)
Arginine finger 528..531 0/2 (0%)
MCM6_C 713..817 CDD:408078 5/14 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 1 1.000 - - FOG0001226
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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